Carbidopa Monohydrate

CAS No: 38821-49-7
Appearance: White to creamy white powder
Standard: USP
Supply Ability: 5000kg per month
Shelf Life: Two years
Payment: T/T, LC or DA
Delivery Time: Ready Stock in Local Warehouse, 1-3 days
Origin: China
Shipping: DHL, FedEx, TNT, EMS, By Sea, By Air
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Product Introduction

We supply Carbidopa Monohydrate

Our company specializes in furnishing high- quality Carbidopa Monohydrate, a pharmaceutical intermediate used in the conflation of medicines for the treatment of Parkinson's complaint. Our product is of the loftiest chastity and is manufactured in a state- of- the- art installation under strict quality control norms to insure its efficacity and safety. We insure timely delivery and offer competitive pricing to our valued guests. Trust us to supply you with the stylish quality Carbidopa api available on the request moment. communicate us moment to place your order.

 

What's Carbidopa Monohydrate?

Carbidopa Powder is a drug that's primarily used in the treatment of Parkinson's complaint. It belongs to a class of medicines known as dopa decarboxylase impediments. it enhances the effectiveness of levodopa, a drug used to replenish depleted dopamine situations in the brain. Dopamine is a neurotransmitter that promotes smooth and coordinated muscle movements. It works to maximize the effectiveness of levodopa by inhibiting the conversion of levodopa into dopamine outside the brain, thereby adding the quantum of levodopa that reaches the brain. This drug is generally taken orally, and the lozenge varies depending on the inflexibility of the case's symptoms. When taken in combination with levodopa, it can reduce the associated adverse goods similar as nausea and vomiting, allowing cases to more manage with Parkinson's symptoms. it may also be used in the treatment of other conditions, similar as restless leg pattern, and as a precautionary measure for certain types of migraines. still, its primary use is in the treatment of Parkinson's complaint.

As with all specifics, it may beget side goods, the most common being headaches, dizziness, and gastrointestinal discomfort. Cases who witness these side goods should bandy with their healthcare professionals to acclimate the lozenge and determine the applicable course of treatment.

 

Basic Information

Product Name: Carbidopa Monohydrate

CAS:38821-49-7

MF:C10H16N2O5

MW:244.25

EINECS:642-905-9

MDL No.:MFCD00889211

Structural formula:

product-1-1

Purity: 99%+

Origin: China

Application: treatment of Parkinson's disease

Delivery Time: in stock

 

Technical Specification

Items

Specifications

Results

Characters

Appearance

White to creamy white powder,odorless or practically odorless

Creamy white powder,odorless

Solubility

Slightly soluble in water;freely soluble in 3 N hydrochloric acid Slightly soluble in methanol;practically insoluble in alcohol,in acetone,in chloroform,and in ether.

Meets the requirements

Identification

A、IR

The spectrum of sample complies with the spectrum obtained with standard

Complies

B、Assay:RT

Corresponds to the peak obtained with the standard

Complies

Assay

98.0%~102.0%

99.3%

Residue on ignition

Not more than 0.1%

0.02%

Methyldopa

Not more than 0.5%

0.19%

Carbidopa related compound A

Not more than 0.5%

Undetected

Any other impurity

Not more than 0.10%

0.05%

Total impurities

Not more than 1.0%

0.2%

Specific rotation

-21.0°~-23.5°

-22.2°

Loss on drying

6.9%~7.9%

7.4%

Residual

solvents

Methanol

Not more than 3000ppm

10ppm

2-Propanol

Not more than 5000ppm

Below LOD

Chloroform

Not more than 60ppm

Below LOD

Benzene

Not more than 2ppm

Below LOD

Toluene

Not more than 890ppm

Below LOD

Cyelohexanone

Not more than 20ppm

Below LOD

Conclusion

The batch complies with the USP43 Specifications.

Package: 1kg; 25kg

Storage conditions: keep tightly closed, store in a cool dry place.

 

Biological activity

Carbidopa API is a peripheral decarboxylase inhibitor that can be used in the study of Parkinson's Chemicalbook disease. Carbodopamonohydrate is a selective aromatic hydrocarbon receptor (AhR) modulator. it  inhibits the growth of pancreatic cancer cells and tumors.

 

What is the application?

Carbidopa monohydrate is a medication that is commonly used in the treatment of Parkinson's disease. It is a peripheral decarboxylase inhibitor that works by blocking the conversion of levodopa to dopamine outside the brain. This allows for more levodopa to reach the brain, where it can be converted to dopamine and improve the symptoms of Parkinson's disease.

It is often used in combination with levodopa to enhance its effectiveness. This combination therapy is commonly referred to as carbidopa-levodopa, and it is available in several different formulations, including immediate-release, sustained-release, and extended-release.

In addition to treating Parkinson's disease, it is also sometimes used in the treatment of restless leg syndrome, a condition that causes uncomfortable sensations in the legs and an overwhelming urge to move them. It is believed that it may help to relieve these symptoms by enhancing the effects of dopamine in the brain.

it is typically administered orally, and it is generally well-tolerated by most patients. However, like all medications, it can cause side effects in some individuals. These side effects may include nausea, vomiting, dry mouth, dizziness, and constipation. In rare cases, it may also cause more serious side effects such as hallucinations or confusion.

Overall, it is an important medication that plays a key role in the treatment of Parkinson's disease and other movement disorders. It enhances the effectiveness of levodopa and helps to relieve the symptoms of these conditions.

 

In vitro research

Carbidopa χ PC3andCapan-2cells, named the introduction of CYP1A1 and CYP1A2, which are shared by AhRantagonistsuchasCH223191.Carbidopa, aaromatic L-amino acidde carboxylaseinhibitor, isselectively cytChemical bookotoxicto human pulmonary carcinoma and small cells Cardiopaislethal (IC50=29 uM)

 

In vivo studies

it also induces nuclear uptake of the AhR, and in vivo studies show that carbidopa at a cure of 1 mg/ mouse significantly inhibits excrescence growth in athymic raw mice bearing BχPC3 cells as xenografts.

 

Why Choose Xi'an Yihui?

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as a supplier of Carbidopa monohydrate , Xi'an Yihui has rich production experience and technical knowledge, high-quality products, flexible production capacity, and quality customer service, which can provide better support and service to customers.

if you need Carbidopa API , pls feel free to contact us any time. we will reply you asap.

Our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937

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