Bortezomib Supplier

Xi'an Yihui Company is a professional manufacturer of Bortezomib. We can generate Bortezomib powder with a 99.9% content. It can be utilized in food, medicine, health care items, or cosmetics and meet USP, BP, EP,CP standards. We can offer you products of the highest caliber at the most competitive rates. Your best option for a reputable pure Bortezomib supplier is Xi'an Yihui Company!

What is Bortezomib API?

Bortezomib API is generally used as a proteasome asset. Its chemical name is(( 1R)-3-methyl-1-(( 2S)-1-oxo-3-phenyl-2-(( pyrazin-2-ylcarbonyl) amino) propyl) amino) butyl) boronic acid, its chemical formula is C19H25BN4O4, its molecular weight is384.24 g/ spook, and its CAS number is 179324-69-7. Its chemical structure is an epoxyketone emulsion containing boron, which can bind to the active point of the proteasome tertiary structure in the cell and block its exertion, thereby inhibiting cell growth and proliferation.

It's a white to slightly unheroic solid with a melting point between 122 °C and 125 °C. It's slightly answerable in water, answerable in DMSO and methanol. It has a rotatable boronic ester group, which makes it fluently hydrolyzed in result, so it should be stored and used in dry and humidity-free surroundings. It should be kept in a dry, cool, and dark place, rather in a watertight vessel to maintain its stability.

Its discovery began in the late 1990s, originally delved by a platoon of scientists from ProScript, a biotechnology company in New York, USA( latterly acquired by Millennium Pharmaceuticals). They utilized the effect of proteasomes on neuronal cell growth and differentiation and screened potential inhibitors, including Bortezomib API.

latterly, the medicine was named PS- 341, and after times of clinical exploration and trials, it was officially approved by the US FDA on November 20, 2003 as the first proteasome asset used to treat multiple myeloma. Since also, it has also attained blessings from countries and regions similar as the EU, Canada, and Japan, getting an important extensively used medicine.

In the development process, scientists continuously bettered and strengthened their understanding of the natural mechanisms of proteasomes, promoting exploration and development in affiliated fields.

Basic Information

Quality standard

Functions and applications

Bortezomib fda approval is a proteasome asset used primarily as a chemotherapy agent to treat colorful types of cancers, including multiple myeloma and mantle cell carcinoma. It exerts its remedial effect by blocking the exertion of proteasomes, which are cellular structures responsible for breaking down proteins that are critical for the growth and survival of cancer cells.

Here are the key functions and applications of Bortezomib:

1. Inhibition of proteasomal exertion The primary medium of action is its capability to inhibit the proteasome, a crucial cellular ministry that breaks down proteins, including those that enable cancer cells to grow and gain. By inhibiting proteasomal exertion, it triggers a waterfall of events that eventually lead to the death of cancer cells.

2. Treatment of multiple myeloma Multiple myeloma is a type of cancer that affects the tube cells, a type of white blood cell. it's approved by theU.S. FDA for the treatment of multiple myeloma, either as a standalone remedy or in combination with other chemotherapy medicines. It has been shown to ameliorate survival rates and quality of life in cases with this condition.

3. Treatment of mantle cell carcinoma it's also used to treat mantle cell carcinoma, a rare form ofnon-Hodgkin's carcinoma that affects the lymph bumps, bone gist, and other organs. It's generally used in combination with other chemotherapy medicines and has been shown to be effective in converting absolution in cases with this condition.

4. Targeted remedy it's a targeted remedy that widely targets cancer cells, leaving healthy cells fairly unharmed. This makes it less poisonous than other chemotherapy medicines, which can beget significant side goods.

5. Advanced issues in transplant donors Bortezomib has been shown to ameliorate issues in cases who suffer stem cell transplantation, a procedure used to restore the bone gist in cases with certain types of cancer. By reducing the threat of graft rejection and perfecting the engraftment of patron cells, it has been shown to ameliorate overall survival rates in these cases.

In conclusion, it's a potent chemotherapy agent that inhibits proteasomal exertion, leading to the death of cancer cells. It's used primarily to treat multiple myeloma and mantle cell carcinoma and is frequently used in combination with other chemotherapy medicines. As a targeted remedy, it widely targets cancer cells, making it less dangerous to healthy cells and reducing the threat of side goods.

Stability & Solubility

Bortezomib API has some instability which may affect its storage and usage. It is prone to hydrolysis in solution, where the boronic ester group can be cleaved from the molecule and form inactive metabolic products. It is also easily affected by factors such as oxidation, hydrolysis, and photolysis, leading to faster degradation.

To maintain the stability, the following measures should be taken:

• Avoid contact with moisture and humid environments during storage and transportation, and keep it dry.

• Store it in a cool, dry, and dark place. put is in a sealed container

• Avoid repeated freeze-thaw cycles as this can cause crystallization and decomposition.

• Use dry solvents for preparing solutions, and dissolve them at low temperature immediately before use.

• Avoid long-term shaking, especially during dissolution.

• When using Bortezomib fda label, protect it from oxidation, hydrolysis, or light exposure.

In summary, appropriate storage and usage methods should be taken to maintain stability and avoid unnecessary factors that may affect it.

Packing & Shipping

Packing: 1kg/foil bag;5kg/carton;25kg/fiber drum; or packing as your request.

Customization: Customized logo; Customized packaging; Graphic customization

Shipping:

Payment Term

Why Choose Xi'an Yihui?

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Xi'an Yihui Factory & Warehouse

Our Advantage

Rich experience: we have 13 Years of professional experience;

Customers all over the world: sell to more than 100 countries;

Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.

Price advance: low MOQ with competitive price;

Quality certification: ISO; Halal; Kosher certified

After-sales service: Professional team 7*24 hours customer service.

In conclusion

To sum up, Xi 'an Yihui Company as a professional manufacturer of Bortezomib API, with high-quality products, a high level of research and development capabilities, advanced production equipment and technology, perfect after-sales service, and other advantages, is the customer choice of the ideal partner.

if you need it, pls feel free to contact us any time. we will reply to you ASAP.

our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937

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