What is Dexamethasone sodium phosphate powder?

Dexamethasone sodium phosphate powder is a type of corticosteroid drug with the chemical name sodium( 11beta, 16alpha) phosphate. It's a tintless or nearly tintless crystalline powder with the molecular formula of C22H28FNa2O8P and molecular weight of 516.4 g/ spook, and its CAS No is2392-39-4.

It can stabilize lysosomal membranes and reduce the release of hydrolytic enzymes from lysosomes, inhibit the product of seditious substances similar as bradykinin, serotonin, and prostaglandins, increase the stability of mast cell grains, and reduce the release of histamine. It can also beget vasoconstriction, inhibit the migration of leukocytes and macrophages outside blood vessels, and therefore have an anti-inflammatory effect. It can ply immunosuppressive goods by inhibiting macrophage function. It can inhibit the conformation of fibroblasts, which is salutary for precluding corneal scarring. When used in trauma, it can reduce scar conformation and cover vision. In corneal and conjunctival conditions, it can inhibit or reduce the conformation of neovascularization. When used locally in corneal transplantation surgery and treatment of diplopia surgery, it can reduce rejection responses and scar conformation. It's clinically used to treat colorful conditions similar as autoimmune conditions, disinclinations, inflammation, rheumatism, asthma, ophthalmology, and dermatology.

Basic Information

Product name: Dexamethasone sodium phosphate

Chemical name: sodium (11beta,16alpha)-9-fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl phosphate

Other name: dexamethasone 21-phosphate disodium salt

CAS: 2392-39-4; 55203-24-2

MF: C22H28FNa2O8P

MW: 516.4

EINECS:200-003-9

MDL No.:MFCD00079105

Melting point:233-235 °C

storage temp. 2-8℃

Stability: Stable

Structural formula:

Quality standard

Pharmacokinetics

Dexamethasone sodium phosphate API is a corticosteroid medicine with analogous pharmacological characteristics to hydrocortisone, but it has advanced energy( 40- 50 times more potent in terms of anti-inflammatory goods compared to hydrocortisone) and brisk onset of action. It has minimum side goods and can snappily enhance fleshly functions, making it particularly suitable for exigency treatment of critical conditions. The medicine has strong goods on glucose metabolism, anti-inflammatory,anti-toxic, and anti-allergic conduct. It has mild goods on water retention, sodium retention, and potassium excretion. It exhibits strong pituitary- adrenal repression, hence causing lower adverse responses similar as edema, hypertension, and muscle weakness. Dexamethasone sodium phosphate undergoes metabolism and conversion in the liver and is excreted through urine from the feathers, thus, the tube half- life of the medicine may be dragged in individualities with bloodied liver or order function. When administered by intramuscular injection, the medicine reaches peak blood attention within 1 hour, and its tube protein list rate is lower than that of other corticosteroid medicines.

Function

Dexamethasone sodium phosphate powder has multiple functions, mainly including the following aspects:

•  Anti-inflammatory effects

It can palliate and help towel responses to inflammation. In the early stage of acute inflammation, it inhibits capillary permeability, leukocyte infiltration, and phagocytic responses, reduces the release of colorful seditious intercessors, and thereby alleviates original edema caused by exudation; in the after stage of inflammation, it inhibits capillary and fibroblast proliferation and collagen conflation, prevents adhesions and scar conformation.

• Immunosuppressive and anti-allergic effects

This medicine can help or inhibit cell- intermediated vulnerable responses, delayed- type antipathetic responses, reduce the number of T lymphocytes, monocytes, and eosinophils, drop the list capability of immunoglobulin and cell face receptors, and inhibit the conflation and release of interleukins, thereby reducing the metamorphosis of T lymphocytes into lymphoblasts, inhibiting pathological changes caused by antipathetic responses, similar as antipathetic traffic, edema, exudation, rash, smooth muscle spasms, and cellular damage. The medicine also reduces the passage of vulnerable complexes through the basement membrane and can reduce the attention of complement factors and immunoglobulins. also, it can inhibit transplant rejection responses and have certain short- term efficacity for autoimmune conditions.

• Treatment of ophthalmic diseases

It inhibits corneal epithelial rejuvenescence and can inhibit or reduce the conformation of neovascularization in corneal and conjunctival conditions.

Application:

Dexamethasone sodium phosphate has a wide range of operations and is generally used in the following situations

1. Inflammatory diseases: it has significantanti-inflammatory goods in colorful seditious conditions similar as arthritis, dermatitis, and antipathetic responses. It can palliate pain, swelling, and greenishness caused by inflammation.

2. Respiratory system diseases: This drug is extensively used in the treatment of respiratory conditions similar as asthma, bronchitis, and habitual obstructive pulmonary complaint. It can reduce seditious responses in the respiratory tract and palliate symptoms similar as difficulty breathing and coughing.

3. Immune system diseases: it can be used to treat colorful autoimmune conditions similar as rheumatoid arthritis and systemic lupus erythematosus. It alleviates symptoms and course of the conditions by suppressing vulnerable responses and reducing inflammation.

4. Cancer treatment: This medication shows some effectiveness in combating certain malignancies such as leukemia and malignant lymphoma. It can reduce tumor cell growth and alleviate symptoms by suppressing inflammation.

5. Other uses: In addition to the above common application areas, it can also be used for the treatment of adrenal insufficiency, adjunctive treatment of congestive heart failure, and management of stress states before and after surgery.

Packing & Shipping

Packing: 1kg/foil bag;5kg/carton;25kg/fiber drum;or packing as your request.

Customization: Customized logo; Customized packaging; Graphic customization

Shipping:

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Our advantage

Rich experience: we have 13 Years of professional experience;

Customers all over the word: sell to more than 100 countries;

Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.

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In conclusion

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