Docetaxel Powder
MF:C43H53NO14
MW:807.88
Package: 10g/bag;100g/bag;1kg/bag
Origin: China
Supply Ability: 500kg per month
Sample Available: Yes
Payment: T/T, LC or DA
Certifications: ISO9001, ISO22000, HACCP, HALAL, KOSHER
Third Party Test: available
Can't sell to individuals
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Product Introduction
What is Docetaxel powder?
Docetaxel powder is a taxoid-class outgrowth of paclitaxel, which is uprooted from the dinghy of the yew tree. It's a water-indoable white to pale unheroic crystalline powder with a molecular formula of C43H53NO14 and a relative molecular mass of 807.88 g/ spook. Its chemical name is( 2α, 3β, 5β, 7β, 10β, 13α)-4-acetoxy-13-({( 2R, 3S)- 3-(( tert- butoxycarbonyl) amino)-2-hydroxy-3-phenylpropanoyl} oxy) benzoate, and its CAS number is 114977-28-5.
The production process of Docetaxel API mainly includes the following steps:
Extraction its precursor from paclitaxel
Firstly, paclitaxel is chemically converted into 10-deacetylbaccatin III precursor. This process usually requires solvents and catalysts.
Synthesis
also, 1,2- di- phenyl-1-thioacetoxyethane( DTE) is used as an intermediate for the full conflation of Docetaxel. A series of organic chemical responses are needed in this process, and alkaline catalysts are used to help the response.
Purification and crystallization
After the response, the product needs to be purified and formed to gain high chastity and good crystallinity of Docetaxel chargers. Detergents similar as isopropanol can be used for birth and sanctification during this process.
Grinding and testing
The chargers need to suffer grinding and quality testing to produce a final product that meets the standard.
The entire product process requires strict specialized operations and quality control to ensure that the produced products meet the medical quality norms and can be safely and effectively used in cancer treatment.
Basic Information
Product name | Docetaxel |
Chemical name | (2α,3β,5β,7β,10β,13α)-4-acetoxy-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate |
CAS | 114977-28-5 |
MF | C43H53NO14 |
MW | 807.88 |
EINECS | 601-339-2 |
MDL No. | MFCD00871399 |
Purity | 99% |
Stability | stable when stored under appropriate conditions. |
Application | Medicine grade or used for research. |
Packing | As per your request |
Storage | Room temp. |
Structural formula | |
Quality standard
TEST | SPECIFICATIONS | RESULT | |
APPEARANCE | White or almost white crystalline powder | Conforms | |
SOLUBILITY | Practically insoluble in water,freely soluble in anhydrous ethanol, soluble in methylene chloride. | Conforms | |
SPECIFIC OPTICAL ROTATION | -41.5°~-38.5° | -40.2 ° | |
IDENTIFICATION | The IR spectrum of sample corresponds to that of reference standard | Conforms | |
APPEARANCE OF SOLUTION | The solution is not more opalescent than reference suspension (2.2.1)and not more intensely coloured than reference solution B5(2.2.2,Method I ) | Conforms | |
(HPLC) RELATED COMPOUNDS | Impurity A | NMT 0.2% | 0.04% |
Impurity B | NMT 0.3% | 0.05% | |
Impurity C | NMT 0.15% | 0.01% | |
Impurity E | NMT 0.15% | Undetected | |
Other Impurities | NMT 0.1% | 0.02% | |
Total Impurities | NMT 0.8% | 0.13% | |
RESIDUAL SOLVENT | Ethyl Acetate | NMT 5000ppm | 600ppm |
n-hexane | NMT 290ppm | Undetected | |
WATER | NMT1.5% | 0.91% | |
SULFATED ASH | NMT 0.1% w/w | 0.04% | |
HEAVY METALS | NMT 20ppm | <20ppm | |
BACTERIAL ENDOTOXINS | NMT 0.3 IU/mg | Conforms | |
ASSAY | 98.0%~102.0% (anhydrous substance) | 99.5% | |
CONCLUSION | The product is in accordance with EP to test the above—mentioned items, The test results conform to the specification. |
Stability & Storage
For Stability, Docetaxel powder should be kept in a dry, cool, dark, and sealed container to prevent moisture and light-mediated decomposition. It should be kept away from high temperatures, high humidity, and flame sources. Generally, it should be stored at the temperature -20°C or lower. If long-term storage is required, the use of oxygen scavengers and inert gases can help protect its stability.
For usage, it needs to be diluted and prepared in an appropriate solvent and used as quickly as possible after preparation. When mixed with other drugs, its compatibility needs to be carefully considered. Its injection solution should be used immediately after preparation and should not be mixed with or added to other drugs. Its stability also needs to be preserved during usage, such as avoiding exposure to sunlight, avoiding shaking or vigorous vibration.
Overall, strict control of environmental conditions is necessary to ensure its stability and efficacy during storage and usage. Docetaxel API should be used according to clinical guidelines and physician recommendations to guarantee its therapeutic effects.
It needs to be stored under specific conditions to ensure its stability and efficacy. Generally, the following are the standard storage conditions:
Temperature: It should be stored at a frozen temperature in-20 °C or below to avoid high temperatures or freezing. During the medication process, the set result should be instantly placed in a low- temperature refrigerator or freezer for the storehouse.
Humidity: It should be stored in a dry environment to prevent moisture or freezing. Therefore, the storage space should be as dry as possible, and auxiliary tools such as dehumidifiers can be considered.
Light avoidance: It should be kept away from direct sunlight or strong light exposure to prevent decomposition or degradation. Therefore, the storage space should be well-ventilated, and light-shielding cloth or cabinets can be used for protection.
Container: Docetaxel Trihydrate should be stored in sealed glass or polyethylene bottles, icing that the bottle's seal is good. Before use, it should be checked that the bottle is complete, and opened or damaged bottles shouldn't be used.
In summary, to ensure its quality stability and consistency, it is necessary to strictly follow the above conditions during storage and usage. If long-term storage is required, the use of oxygen scavengers and inert gases can be considered, and regular quality testing should be performed to ensure its efficacy and safety.
Packing & Shipping
Packing: 1kg/foil bag;5kg/carton;25kg/fiber drum; or packing as your request.
Customization: Customized logo; Customized packaging; Graphic customization
Shipping:
Item | Quantity | ETA time | Shipping Method |
By Courier | ≤50kg | 7-15days | Fedex, DHL,UPS,TNT,EMS ect. Fast and convenient |
By Air | 50kg~200kg | 3-5days | Fast and cheap |
By Sea | Large quantity | 20-35days | Cheapest way |
Payment Term
Why Choose Xi'an Yihui?
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Our Advantage
Rich experience: we have 13 Years of professional experience;
Customers all over the world: sell to more than 100 countries;
Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.
Price advance: low MOQ with competitive price;
Quality certification: ISO; Halal; Kosher certified
After-sales service: Professional team 7*24 hours customer service.
In conclusion
In summary, as a professional Docetaxel powder manufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make it stand out in the market competition and win more customer trust and support. if you need it, pls feel free to contact us any time. we will reply you asap.
Our contact information:
E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
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