We supply Methotrexate API

Our company is proud to offer Methotrexate API, a largely effective drug used to treat colorful types of cancer, rheumatoid arthritis, and psoriasis. it works by inhibiting the growth and replication of cancer cells and reducing inflammation in arthritis and psoriasis cases. Our products is of the loftiest quality and chastity, and we assure our guests that it's manufactured in compliance with transnational norms. Our platoon of experts follows strict quality control and testing procedures to insure that our guests admit the stylish possible product. communicate us moment to learn further about our Methotrexate powder and how it can profit your business.

What's Methotrexate?

Methotrexate is a medicine used to treat cancer, also known as cell bane. It's substantially used to treat acute leukemia( acute lymphoblastic leukemia), bone cancer, choriocarcinoma and nasty operative, head and neck cancer, bone excrescences, leukemia meninges and spinal cord infiltration, lung cancer, reproductive system excrescences, liver cancer, stubborn psoriasis vulgaris, dermatomyositis, physical myositis, ankylosing spondylitis, Crohn's complaint, psoriasis and psoriatic arthritis, Behcet's complaint, and autoimmune conditions. It has a particularly good remedial effect on synovitis in rheumatoid arthritis and is one of the most generally used medicines for cases with rheumatoid conditions.The main side goods include nausea, puking and diarrhea, liver dysfunction, oral ulcers, pneumonia, sepsis and Nocardia, mild fatigue and headache, and dry skin.

Discovering History

it was the first effective anti metabolite in the treatment of excrescences, with good remedial goods on chorionic epithelial melanoma and acute lymphoid leukemia. In the 1940s, scientists discovered that the effective component in Lactobacillus casei that inhibits transplanted excrescence sarcoma S180 and robotic bone cancer in mice is tyrosine triglutamate, which has a weak anti folate effect; And it was observed that the lack of folic acid inhibited bone gist; Folic acid can promote the development of leukemia and other marvels, so we began to search foranti-cancer medicines from folate metabolites. In 1947, it was used in clinical trials and was effective in treating nonage leukemia. latterly, it was set up that it had a high remedial indicator for mouse leukemia L1210. It was tested clinically in the 1950s and snappily replaced it for leukemia treatment, and latterly expanded to treat other excrescences. It's one of the most considerably studiedanti-tumor medicines.

Although Gubner successfully applied it to treat rheumatoid arthritis and psoriasis in 1951 in the field of rheumatoid arthritis. But at that time, it was still considered an anti metabolicanti-cancer medicine, and naturally people believed that its toxin was still too high. Another reason is the emergence of hormones, which leads to nearly all attention being concentrated on hormone remedy. Only a many experimenters in the field of rheumatism, including RexHoffmeister and others, have started using low- cure methotrexate to treat autoimmune conditions.

Basic Information

Product Name: Methotrexate

CAS:59-05-2

MF:C20H22N8O5

MW:454.45

EINECS:200-413-8

MDL No.:MFCD00064370

Structural formula:

Purity: 99%+

Origin: China

Application: Anti-neoplastic; Anti-Cancer

Delivery Time: in stock

Technical Specification

Package: 1kg; 25kg

Storage conditions: keep tightly closed, store in a cool dry place.

Wat is the Application?

Methotrexate API is a good anti-tumor drug, used for acute lymphoid leukemia, lymphoma, malignant mole, choriocarcinoma, squamous cell carcinoma, lung cancer, cervical cancer, breast cancer, osteosarcoma, etc. After oral administration for 12 hours, 90% of the original drug is excreted from the urine, and the main metabolite is 7-hydroxymethotrexate. The LD50 for intravenous injection into rats is 14mg/kg.

Folate antagonists, inhibitors of dihydrofolate reductase.

Antitumor drugs, used for various acute leukemia, chorionic epithelial cell carcinoma, malignant molar pregnancy, and psoriasis

Wat is the Immunosuppressants?

Methotrexate powder is an anti folate metabolite drug with strong immunosuppressive effects. It is the earliest and most successful anti folate preparation used in clinical practice. It is not only effective for leukemia, but also has good therapeutic effects on solid tumors, making it one of the basic anti-tumor drugs in clinical practice. it can selectively act on proliferating cells, preventing the division and proliferation of immune mother cells. It has inhibitory effects on both humoral and cellular immunity, as well as strong anti-inflammatory effects. It has inhibitory effects on initial and secondary immune responses, delayed allergic reactions, and transplant versus host reactions. The immunosuppressive effect is strongest when administered simultaneously with antigen stimulation or 1-2 days later, and medication is ineffective before antigen stimulation. Clinically, it is mainly used for the treatment of autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, and dermatomyositis. In addition, it is effective for acute leukemia, choriocarcinoma, osteosarcoma, breast cancer, testicular tumor, etc. A cycle specific drug commonly used in combination chemotherapy regimens.

Wat is the pharmacological action?

It is a folate based anti-tumor drug that has inhibitory effects on various animal tumors. Experiments have shown that this drug works by competitively inhibiting dihydrofolate reductase. Dihydrofolate reductase is an important enzyme in DNA synthesis, particularly essential for the conversion of folate to tetrahydrofolate and deoxyuridine nucleoside methylation to thymine nucleoside. This drug selectively acts on the DNA synthesis phase (i.e. S phase) and is a cycle specific drug. Recently, some people believe that this product has a second point of action, which is the G1/S transition period. It can also inhibit the synthesis of interleukin-2 and the chemotaxis of neutrophils, so it has immunosuppressive and anti-inflammatory effects. At high doses, it also has a direct toxic effect on non proliferating cells, especially liver cells, and CF is commonly used as an antidote in clinical practice.

The structure is similar to that of folic acid. The hydrogen of the hydroxyl group at position 4 and the NH at position 10 of folic acid in MTX are amino and CH3, respectively. MTX binds to dihydrofolate reductase, blocking the reduction of folate and dihydrofolate to activated tetrahydrofolate, thereby inhibiting intracellular carbon transfer, affecting the synthesis of purines and the conversion of deoxyuridine nucleotides to deoxytymidine nucleotides, thereby hindering DNA and RNA synthesis. The concentration of MTX in plasma reaches 10-8 mol/L, which can effectively block the incorporation of deoxyuridine nucleotides into DNA through deoxytymidine nucleotides, while inhibiting purine synthesis at a concentration of 10-7 mol/L. The binding of MTX to dihydrofolate reductase is reversible but strong. Only when the amount of dihydrofolate is 1000 times higher than MTX can it counteract the binding of MTX. In vitro, when MTX is below the concentration that completely inhibits DNA synthesis, it can induce differentiation of human chorionic epithelial carcinoma cells and increase the production of chorionic gonadotropins. MTX is a cell cycle specific drug that mainly acts on S-phase cells and also has a certain effect on G1 phase, with a delaying effect on G1/S.

Wat is the Pharmacokinetics?

This product has good oral absorption, and the blood drug concentration reaches its peak after 30-60 minutes. When taken in large doses or with food, absorption is poor. After intramuscular injection, the blood concentration is maintained for a long time, and the disappearance of intrathecal injection drugs is slow. The concentration in cerebrospinal fluid can be maintained for about 6 days. After absorption, 60% to 85% of this product binds to plasma proteins. Taking aspirin or sulfonamide drugs simultaneously can increase the blood drug concentration of this product, resulting in increased efficacy and toxicity. Poor liver and kidney function can also increase the toxicity of this product. This product can pass through the blood-brain barrier in small amounts. The distribution of drugs in the body is mainly in the liver and kidneys, and there is also a portion in the bone marrow. The half-life of the drug plasma is 2 hours. The drug is mainly excreted from the urine in its prototype, with a urine excretion rate of up to 90% within 48 hours. Fecal and biliary discharge is minimal.

Packing & Shipping

Packing: 1kg/foil bag;5kg/carton;25kg/fiber drum; or packing as your request.

Customization: Customized logo; Customized packaging; Graphic customization

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In summary, Xi'an Yihui company as a professional Methotrexate API manufacturer, has strong technical strength and advanced production equipment and is committed to providing customers with high-quality, efficient and reliable drug raw materials. if you need Methotrexate powder, pls feel free to contact us any time. we will reply you ASAP.

our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937