We supply Irinotecan hydrochloride

We're proud to offer Irinotecan hydrochloride API, a largely effective pharmaceutical component that's generally used in the treatment of cancer. Our product is manufactured using the loftiest quality norms to insure its chastity and efficacity, and is available in colorful grades to meet the specific requirements of our guests. With our commitment to quality and client satisfaction, you can trust us to give you with the stylish possible product and service. Order now and witness the benefits of our decoration Irinotecan.

What's Irinotecan hydrochloride?

Irinotecan HCL is asemi-synthetic water-answerable outgrowth of camptothecin. It's a light unheroic greasepaint or light unheroic crystalline greasepaint at room temperature and is odorless. It's slightly answerable in water, ethanol or chloroform, and undoable in acetone. Camptothecin can specifically bind to topoisomerase I, which induces reversible single- beachfront breaks, thereby mellowing the DNA double- beachfront structure; irinotecan and its active metabolite SN- 38 can bind to the topoisomerase I- DNA complex, thereby precluding the reconnection of broken single bonds, thereby producing cytotoxicity, which is time-dependent and specifically acts in the S phase, and is more poisonous than irinotecan. It's suitable for the treatment of cases with advanced colorectal cancer, combined with 5- fluorouracil and folinic acid to treat cases with advanced colorectal cancer who have n't entered chemotherapy before, and as a single medicine to treat cases who have failed chemotherapy rules containing 5- fluorouracil. Irinotecan has a broad diapason and stronganti-tumor exertion in both in vivo and in vitro studies. Importantly, irinotecan and its metabolites are still effective against excrescences expressing multidrug resistance.

Basic Information

Product Name: Irinotecan Hydrochloride

CAS: 100286-90-6

MF:C33H39ClN4O6

MW:623.15

EINECS:600-054-0

MDL No.:MFCD01862255

Melting point:250-256°C (dec.)

Boiling point:257 °C

refractive index 67.7 ° (C=1, H2O)

Structural formula:

Origin: China

Delivery Time: in stock

Technical Specification

Package: 10g; 100g; 1kg;25kg; or according to your demands

Storage: Preserve in tight,light-resistant containers in cool place

Shelf Life:Powder: 2 years

Application

Irinotecan hydrochloride API is a largely effective pharmaceutical component that's used in the treatment of cancer. The medicine works by inhibiting an enzyme known as topoisomerase I, which is responsible for cell division. By precluding the division of cancer cells, it helps to decelerate down and control the growth of excrescences.

One of the crucial advantages is its capability to target a wide range of cancer types. This includes colorectal cancer, gastric cancer, lung cancer, and other solid excrescences. In addition to this broad connection, the medicine has also been shown to have a lower threat of toxin compared to analogous treatments. In clinical studies, it has shown promising results in perfecting survival rates and reducing the prevalence of side goods.

The medicine is generally administered intravenously under the supervision of a healthcare professional. The cure and duration of treatment will depend on several factors, including the type and stage of cancer, the case's overall health, and other specifics they may be taking.

In terms of side effects, it can beget some cases to witness diarrhea, nausea and vomiting, or a drop in white blood cell count. still, these side goods can generally be managed with drug or other interventions.

Overall, it is a largely effective pharmaceutical component that has proven to be an important tool in the fight against cancer. With its broad connection and low threat of toxin, it's an option that healthcare professionals can turn to for their cases in need of cancer treatment.

Biological Activity

Irinotecan hcl is a potentanti-cancer agent with a unique medium of action. It's a topoisomerase I asset that widely targets fleetly dividing cancer cells, making it an effective treatment option for a variety of cancers, including colorectal, lung, and ovarian cancer.

Studies have shown that it has significant natural exertion against cancer cells, with the medicine flaunting potentanti-proliferative goods. Clinical trials have demonstrated the efficacity in reducing excrescence size and perfecting survival rates in cases with metastatic colorectal cancer and in other types of cancers.

The natural exertion is intermediated through its inhibition of topoisomerase I, an enzyme that's pivotal for DNA replication and recap. By inhibiting this enzyme, it can induce DNA damage and apoptotic cell death in cancer cells.

In addition to its direct goods on cancer cells, it has been shown to modulate the excrescence medium, potentially enhancing the body's vulnerable response to cancer. The medicine is also associated with a low prevalence of side goods, making it a well- permitted treatment option for numerous cancer cases.

Overall, it represents a promising option for the treatment of cancer, with its unique medium of action and potent natural exertion making it largely effective against a range of cancer types. As similar, it has set up a place as a crucial remedial agent in the fight against cancer.

In vitro studies

Irinotecan is actuated by carboxylesterase to SN- 38, allowing it to interact with its target, topoisomerase I. Irinotecan at IC50 attention convinced analogous quantities of cleavable complexes in LoVo cells and HT- 29 cell lines. SN- 38 convinced attention-dependent conformation of cleavable complexes, which was n't significantly different in LoVo cells and HT- 29 cell lines. Irinotecan- convinced cell accumulation was significantly different, with constantly advanced situations in HT- 29 cells than in LoVo cells. The lactone E ring of Irinotecan and SN- 38 hydrolyze reversibly in waterless result, and the interconversion between the lactone form and the carboxylate form depends on pH and temperature. Irinotecan is primarily actuated by the liver to SN- 38. For the same attention of irinotecan and SN- 38 glucuronide, the β- glucuronidase- intermediated SN- 38 yield was advanced than the SN- 38 yield formed by irinotecan in both excrescences and normal apkins. Irinotecan is converted to SN- 38 in the intestine, tube and excrescence towel. The exertion of irinotecan in SCLC cell lines was significantly advanced than that in NSCLC cell lines, while no significant difference in SN- 38 was observed in histological typing.

In vivo studies

Irinotecan convinced minimal growth inhibition of 92 in COLO320 xenografts. A single cure of Irinotecan significantly increased the quantum of topoisomerase I covalently bound to DNA in the stomach, duodenum, colon and liver. At the same time, the number of DNA beachfront breaks in colon mucosal cells in the Irinotecan- treated group was significantly advanced compared with the control group.

Our Advantage

Rich experience: we have 13 Years of professional experience;

Customers all over the world: sell to more than 100 countries;

Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.

Price advance: low MOQ with competitive price;

Quality certification: ISO; Halal; Kosher certified

After-sales service: Professional team 7*24 hours customer service.

Contact us

In summary, as a supplier of Irinotecan hydrochloride API , Xi'an Yihui has rich production experience and technical knowledge, high-quality products, flexible production capacity, and quality customer service, which can provide better support and service to customers.

if you need Irinotecan HCL, pls feel free to contact us any time. we will reply you asap.

Our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937