We supply Loperamide hydrochloride API

Our company is proud to offer high- quality Loperamide hydrochloride Active Pharmaceutical component for pharmaceutical companies and exploration institutions. Loperamide hydrochloride is a drug used to treat diarrhea, and our API meets strict quality norms to insure optimal efficacity and safety. Our platoon of experts oversees every step of the manufacturing process, from raw accoutrements sourcing to final product testing, to insure our API meets the loftiest quality norms. We're committed to furnishing exceptional service and prompt, dependable delivery to our guests, and we look forward to erecting long- lasting hookups in the pharmaceutical assiduity.
 

What is Loperamide hydrochloride?

Loperamide hydrochloride API refers to the active pharmaceutical component of the extensively usedanti-diarrhea drug. It's a synthetic opioid agonist that's primarily used to treat diarrhea caused by colorful factors, including viral or bacterial infections, food poisoning, and seditious bowel complaint. The medicine works by decelerating down the exertion of the digestive system, which results in lower fluid and electrolyte loss, and accordingly, lower frequent bowel movements.
Loperamide hydrochloride is available in colorful forms, including tablets, capsules, and liquids. It's generally taken orally and is fleetly absorbed into the bloodstream. Due to its potentanti-diarrhea effect, the drug is generally used in medical settings, similar as hospitals and conventions, as well as by individualities suffering from diarrhea.
In addition to its primary use in treating diarrhea, it may also be used off- marker to manage symptoms of other medical conditions, similar as perverse bowel pattern. still, it's essential to note that the medicine should only be used under the supervision of a healthcare professional, as indecorous use can lead to severe adverse goods similar as constipation, abdominal pain, and bowel inhibition.
Overall, Loperamide hcl API is an essential medicinal component that plays a vital part in managing diarrhea and other affiliated symptoms. As with any drug, it's essential to use the medicine only as directed by a professional healthcare provider and report any adverse goods incontinently.

Basic Information

Product Name: Loperamide Hydrochloride

CAS: 34552-83-5

MF:C29H34Cl2N2O2

MW:513.5

EINECS:252-082-4

MDL No.:MFCD00058581

Structural formula:

Application: Antidiarrheal

Origin: China

Delivery Time: in stock

Technical Specification

Package:1kg, 5kg, 25kg, or according to your demands

Storage conditions: Preserve in tightly closed container between 2-8°C

Shelf Life: 24 months

Application

Loperamide hydrochloride API is primarily used as ananti- diarrheal medicine, but its applications extend beyond just treating diarrhea. also are some pivotal applications:

Anti-Diarrheal Agent : it is considerably used to treat acute and habitual diarrhea. It works by braking down the movement of the bowel, which reduces the frequency of bowel movements and helps to meliorate excreta consistence.

perverse Bowel Pattern( IBS):  In addition to its use in diarrhea, it can also be specified to manage symptoms of perverse bowel pattern, particularly diarrhea- predominant IBS( IBS- D).

Gastrointestinal conditions:  It may be used to manage symptoms in various gastrointestinal conditions where diarrhea is a prominent point, analogous as inflammatory bowel complaint( IBD) during flare- ups.

Opioid- Induced Constipation: it is sometimes used off- marker to palliate constipation associated with opioid use. It acts locally in the gut to brake down motility and increase water absorption, thereby easing constipation.

Research and Development Beyond clinical applications, it is also used in disquisition settings to study gastrointestinal motility and to develop new phrasings for controlling intestinal vehicle.

Veterinary Medicine It has applications in veterinary medicine for managing diarrhea in faves and beast, under the guidance of a veterinarian.

Implicit Anticancer parcels There's ongoing disquisition into the implicit use of loperamide hydrochloride in combination with other drugs to enhance their delivery to cancerous apkins, particularly in the treatment of multidrug- resistant excrescences.

chemical property

Loperamide hcl API C29H34Cl2N2O2. Formed from isopropanol, with a melting point of 222- 223 ℃. Maximum UV absorption(0.1 asset/ L hydrochloric acid/ 2- propanol, 10 ml/ 90m1) 253259265273nm( ε 532648581233). Solubility( g/ 100 ml) water( pH1.7)0.14, citrate phosphate( pH6.1)0.008, citrate phosphate( pH7.9) ＜0.001, methanol28.6, ethanol5.37, 2- propanol1.11, dichloromethane35.1, acetone0.20, ethyl acetate0.035, ether ＜0.001, hexane ＜0.001, toluene0.001, dimethylformamide10.3, tetrahydrofuran0.32, 4- methyl-2-pentanone0.020, propylene glycol5.64, polyethylene glycol4001.40, dimethyl sulfoxide20.5, 2- butanone0.18. pKa8.66. Within the physiological pH range, it's nearly insolvable in water(0.002%). Stable, can be stored for several times under normal conditions. Not hygroscopic and asleep to light. Acute poison. Mice( mg/ kg) 75 subcutaneous injection; 105 oral. Acute poison LD50 rats( mg/ kg) 185 oral.

Production methods

Using diphenylacetonitrile as the raw material, it reacts with epoxyethane in the presence of sodium amino, hydrolyzes with hydrochloric acid, and also opens the ring with 48 HBr HAc at room temperature. After chlorination and dimethylamination, it condenses with 4- chlorophenyl-4-hydroxypyridine in the presence of methyl isobutyl ketone and sodium carbonate to gain loperamide. Calculated predicated on diphenylacetonitrile, the total yield is13.4%.

After the response of diphenylacetonitrile( I) and sodium amino, ethylene oxide is introduced at 5- 10 ℃. After completion and insulation, the response was carried out at room temperature to gain conflation( II) with a yield of 66. Add a 36 hydrogen bromide result of glacial acetic acid to conflation( I) and stir at 25- 30 ℃. Sludge and wash with water until the pH value is 5. Dry conflation( III) with a yield of 88%. conflation( III) was chlorinated with sulfoxide chloride to form conflation( IV) with a yield of 95. conflation( IV) and sodium carbonate are dissolved in toluene and water, and dimethylamine is introduced at 0- 5 ℃ for insulation. The water caste is pulled with chloroform and the extract is concentrated. The residue was recrystallized with methyl isobutyl ketone to gain conflation( V) with a yield of 56%. conflation( V), conflation( VI), sodium carbonate, and potassium iodide were dissolved in methyl isobutyl ketone and vanquished to affluence dehydration. Reduce pressure to recover soap, heat and dissolve the residue in isopropanol, pass through an alumina column at 40 ℃, decolorize and sludge, and add hydrogen chloride isopropanol affect to a pH value of 3. Cool to 5 ℃, sludge and solidify, wash with isopropanol to a pH value of 6, vacuum alkie at 80 ℃ to constant weight, and gain loperamide with a yield of 58%.

Packing & Shipping

Packing：1kg/foil bag;5kg/carton;25kg/fiber drum;or packing as your request.

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Why Choose Xi'an Yihui?

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Our advantage

Rich experice: we have 13 Years professional experience;

Customers all over the word: sell to more than 100 countries;

Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.

Price advance: low MOQ with competitive price;

Quality certification: ISO; Halal; Kosher certified

After-sales service: Professional team 7*24 hours customer service.

Contact Yihui:

As a professional Loperamide hydrochloride API manufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make it stand out in the market competition and win more customer trust and support. if you need it, pls feel free to contact us any time. we will reply you asap.

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E-mail: sales@yihuipharm.com
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