We supply Lomustine API

Our company offers high- quality Lomustine API, a chemotherapy medicine used in the treatment of brain excrescences, lung cancer, and Hodgkin's carcinoma. Our API is manufactured using advanced technology and strict quality control norms to insure chastity and efficacity. We also give comprehensive specialized support and attestation to grease the use of our product. Our platoon is devoted to furnishing exceptional client service and meeting the requirements of our guests. Trust us for all your Lomustine needs, and join the numerous satisfied guests who have served from our products.

What is Lomustine?

Lomustine powder (CCNU), also known as 1-( 2- chloroethyl)-3-cyclohexyl-1-nitroso urea, is an organic emulsion with the chemical formula C9H16ClN3O2. This product is a light unheroic crystalline greasepaint; Odorless. It's fluently answerable in chloroform, answerable in ethanol or carbon tetrachloride, slightly answerable in cyclohexane, and nearly undoable in water. Melting point 90 ℃. The solubility in water,0.1 N sodium hydroxide result,0.1 N hydrochloric acid, or 10 ethanol is each lower than0.05 mg/ ml; Dissolved in anhydrous ethanol at 70 milligrams per milliliter, slightly answerable in propylene glycol.

it is an alkylating agent typeanti-tumor medicine that'snon-specific for the cell cycle. It's utmost sensitive to cells located at the G1- S boundary or early S stage, and also has inhibitory goods on the G2 phase. It has strong lipophilicity and can pass through the blood- brain hedge and enter the cerebrospinal fluid. It's generally used in primary brain excrescences( similar as glioblastoma) and secondary excrescences to treat solid excrescences, similar as combination remedy for gastric cancer, rectal cancer, bronchogenic lung cancer, nasty carcinoma,etc.

On October 27, 2017, the International Agency for Research on Cancer of the World Health Organization released a primary list of carcinogens for reference, with 1-( 2- chloroethyl)-3-cyclohexyl-1-nitroso urea listed as a Class 2A carcinogen.

Basic Information

Product Name: Lomustine

CAS:13010-47-4

MF:C9H16ClN3O2

MW:233.7

EINECS:235-859-2

MDL No.:MFCD00012392

Structural formula:

Application: Anticancer

Origin: China

Delivery Time: in stock

Technical Specification

Package: 100g ;1kg; 5kg or according to your demands

Storage conditions: Preserve in tightly closed container between 2-8 ℃

Shelf Life: 24 months

Application

Lomustine API, also known as CCNU( 1-( 2- Chloroethyl)-3-cyclohexyl-1-nitrosourea), is a chemotherapy medicine primarily used in the treatment of certain types of brain excrescences, similar as primary and metastatic brain excrescences and Hodgkin's carcinoma. As an API( Active Pharmaceutical component), it is employed in the expression of pharmaceutical products similar as capsules or tablets for clinical use.Then are some crucial applications :

• Treatment of Brain Excrescences: it is particularly effective in treating brain excrescences, including gliomas, astrocytomas, and metastatic brain excrescences. It's frequently used when other treatments haven't been successful.
• Hodgkin's Lymphoma: it is occasionally used in the treatment of Hodgkin's carcinoma, especially in cases where the complaint has regressed or is resistant to other curatives.
• Medium of Action: it belongs to the class of alkylating agents. It works by snooping with the DNA conflation and eventually causing cell death( cytotoxicity) in fleetly dividing cancer cells.
• Oral Formulation: it is generally administered orally in the form of capsules or tablets. The API is formulated with applicable excipients to insure proper delivery and immersion in the body.
• Combination remedy: It's also used in combination with other chemotherapy agents or treatments to enhance efficacity against certain cancers.
• Veterinary Medicine: it is occasionally used in veterinary drug for the treatment of certain types of cancers in creatures, particularly in tykes .

Overall, Lomustine plays a pivotal part in the treatment authority for specific types of cancers, primarily brain excrescences and Hodgkin's carcinoma, offering cases a remedial option to combat these grueling conditions.

Biological activity

Lomustine powder, as an API( Active Pharmaceutical component), exerts its Biological activity primarily through its medium as an alkylating agent. Then are the crucial aspects of its Biological activity

Alkylation of DNA:  Lomustine belongs to the nitrosourea class of alkylating agents. It crosses the blood- brain hedge effectively, allowing it to target brain excrescences. Once inside the cell, it undergoes metabolic activation, forming largely reactive interceders. These interceders can alkylate DNA at the N7 position of guanine remainders, leading to the conformation of DNAcross-links. This alkylation interferes with DNA replication and recap processes, eventually causing cell death( cytotoxicity).

Cytotoxic goods By damaging DNA: it induces cytotoxic goods particularly in fleetly dividing cells similar as cancer cells. This medium is pivotal in its effectiveness against colorful types of cancers, including brain excrescences and Hodgkin's carcinoma.

Cell Cycle particularity: it's cytotoxic goods aren't entirely cell cycle-specific but tend to affect cells that are laboriously dividing. Cancer cells, which generally have a advanced rate of division compared to normal cells, are more susceptible to it's goods.

Anti-tumor exertion: it is used primarily in the treatment of brain excrescences, where its capability to cross the blood- brain hedge and ply cytotoxic goods on excrescence cells is critical. It's also employed in the treatment of Hodgkin's carcinoma, especially in cases of relapse or resistance to other curatives.

remedial operations: The Biological activity of lomustine is exercised in the expression of pharmaceutical products similar as capsules or tablets for oral administration. These lozenge forms insure proper delivery of the API to the target apkins and organs, maximizing its remedial efficacity while managing implicit side goods.

In summary, lomustine's Biological activity revolves around its capability to alkylate DNA, disrupt cellular processes in cancer cells, and induce cytotoxic goods that are particularly salutary in the treatment of brain excrescences and Hodgkin's carcinoma. Its medium as an alkylating agent underlies its remedial mileage in clinical oncology.

Production methods

2- aminoethanol cyclizes with urea to form 2- oxazolidinone, which also reacts with cyclohexylamine to produce N-( 2- hydroxyethyl)- N'- cyclohexylurea. It's also chlorinated with sulfoxide chloride to gain N-( 2- chloroethyl)- N'- cyclohexylurea, which is also subordinated to nitrification response to gain cyclohexylnitrosamide.

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In summary, as a professional Lomustine powder manufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make it stand out in the market competition and win more customer trust and support. if you need Lomustine API, pls feel free to contact us any time. we will reply you asap.

our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937