What is Crizotinib API ?

Crizotinib API is a raw material. it belongs to the order of tyrosine kinase impediments. It's a small patch organic emulsion with the chemical name N-( 2-{( 1-( 2,6- dichloro-3-fluorophenyl) ethoxy) carbonyl}-4-methyl phenyl)- 2-( 4-( methylamino) pyridine-3-yl) acetamide, its molecular formula is C21H22Cl2FN5O, its relative molecular mass of450.34, its CAS No. is 877399-52-5.

Its chemical structure and name can be classified into the following orders

A substituted benzene ring grounded on a sweet ethoxy carbonyl group( 1-( 2,6- dichloro-3-fluorophenyl) ethylene).

Several different substituted benzene and pyridine rings incorporate multiple sweet and heterocyclic rudiments.

An sweet amine modified by an ethanedioyl imide( N-( 2-{( 1-( 2,6- dichloro-3-fluorophenyl) ethoxy) carbonyl}-4-methylphenyl)- 2-( 4-( methylamino) pyrdin-3-yl) acetamide).

Conflation of sweet amine precursor originally, using styrene, 2,6- dichlorobenzaldehyde, and trimethylamine as starting accoutrements, an sweet amine precursor is synthesized through a condensation response.

Response with platitude The sweet amine precursor is replied with bromine in tetrahydrofuran to gain the corresponding brominated product.

Pd- catalyzed cross-coupling response Using a precautionary catalyst, a cross-coupling response is carried out under a defensive atmosphere to connect the brominated emulsion with the halogenated alkyl group on the sweet ring, forming its core structure.

Crystallization and sanctification The attained Crizotinib is purified using a solvent crystallization system to gain a product with a chastity of 99 or advanced.

Packaging and storehouse Eventually, it's packaged and stored under light-avoiding, dry, and low- temperature conditions.

It should be refocused out that the below process is only a general process, different manufacturers may vary, and the specific way needs to be acclimated and optimized according to the factual situation. In addition, its product also needs to rigorously misbehave with applicable laws, regulations, and quality operation system conditions to ensure product quality and safety.

Basic Information

Quality standard

History and prospects

Crizotinib API is a Tyrosine kinase inhibitor. Here is its development history and prospects:

Discovery and development: it was initially developed by Pfizer in 2007 and was approved by the US FDA for marketing in 2011.

Current usage: It has gradually replaced traditional treatments and become one of the standard methods for treating this disease. Meanwhile, some companies producing new drugs are also engaged in the research and development of innovative drugs based on the molecular structure of it.

Prospects for the future: With the in-depth study of its mechanism, its side effects and tolerance issues are gradually exposed. Therefore, research on improving and innovating it will be one of the trends for future development. At the same time, the research and development of similar drugs based on the molecular structure of Crizotinib will also become an important direction for new drug development.

Packing & Shipping

Packing: 1kg/foil bag;5kg/carton;25kg/fiber drum; or packing as your request.

Customization: Customized logo; Customized packaging; Graphic customization

Shipping:

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Why Choose Xi'an Yihui?

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Our Advantage

Rich experience: we have 13 Years of professional experience;

Customers all over the world: sell to more than 100 countries;

Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.

Price advance: low MOQ with competitive price;

Quality certification: ISO; Halal; Kosher certified

After-sales service: Professional team 7*24 hours customer service.

In conclusion

In summary, as a Crizotinib factory, Xi'an Yihui has strong technical strength, standardized production processes, flexible production capacity, and excellent service quality. It can provide high-quality Crizotinib API and services for customers.

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