Pramipexole Dihydrochloride Monohydrate
MF:C10H20ClN3OS
MW:265.8
Package: 1kg; 25kg
Origin: China
Supply Ability: 3000kg per month
Sample Available: Yes
Payment: T/T, LC or DA
Certifications: ISO9001, ISO22000, HACCP, HALAL, KOSHER
Third Party Test: available
Can't sell to individuals
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Product Introduction
What is Pramipexole 2HCL monohydrate?
Pramipexole dihydrochloride Monohydrate is a dopamine receptor agonist that works by stimulating dopamine D2 and D3 receptors to regulate the activity of dopamine neurotransmitters in the brain. It selectively binds to these receptors to alleviate symptoms of Parkinson's disease and restless legs syndrome. It is a white to off-white crystalline powder that is soluble in water and relatively stable. It is the dihydrochloride salt dihydrate form of Pramipexole, where the hydrochloride salt form enhances its water solubility. Its molecular formula is C10H17Cl2N3S·H2O, and its molecular weight is 302.26 g/mol. Its CAS number is 191217-81-9.
The development history of Pramipexole can be traced back to the 1990s. They are the mileposts in the development of this drug
1988: Pramipexole was first synthesized.
1993: Clinical trials of Pramipexole began for the treatment of motor symptoms in Parkinson's disease.
1997: Pramipexole was approved for prescription use in the United States as a treatment for Parkinson's disease.
2006 Pramipexole was also approved for the treatment of restless legs pattern. It can be used to control symptoms of both Parkinson's complaint and restless legs pattern, particularly in children and adolescents.
2016 Pramipexole appeared as an active component in two separate specifics, approved by the US FDA. This means that Pramipexole can be used as a standalone product or in combination with other specifics.
It as the hydrochloride swab dihydrate form of Pramipexole, improves the medicine's solubility and stability in phrasings. This helps in better controlling the lozenge and enhancing the remedial goods.
Over time, Pramipexole and its hydrochloride swab dihydrate form have gradationally become an important treatment option for cases with Parkinson's complaints and restless leg patterns.
Basic Information
Product name | Pramipexole 2HCL monohydrate |
Other name | Pramipexole HCL |
CAS | 191217-81-9 |
MF | C10H20ClN3OS |
MW | 265.8 |
EINECS | 687-708-9 |
MDL No. | MFCD00876894 |
Purity | 99% |
Stability | Stable |
Application | Medicine grade & Research grade. |
Packing | As per your request |
Storage | Room temp. |
Structural formula | |
Quality standard
Items | Specifications | Results |
Appearance | White or almost white crystalline powder | White crystalline powder |
Solubility | Freely soluble in water, soluble in methanol, slightly soluble in ethanol and practically insoluble in dichloromethane | Conform |
Identification | specific optical rotation IR Enantiometric impurity D not more than 0.5% It gives chloride reaction | Conform |
Appearance of solution | Not more intensely coloured than reference solution Y6 | Conform |
Specific optical rotation | -67°～-69.5°(C=1.0, methanol) | 68.2° |
pH | 2.8~3.4 | 3.00 |
Related substances Impurity A Impurity B Impurity C Any unspecified impurity Total impurity | ≤0.15% ≤0.15% ≤0.15% ≤0.10% ≤0.50% | 0.114% Not found Not found Not found 0.114% |
Enantiomeric | ≤0.50% | 0.05% |
Heavy metals | ≤10ppm | < 10ppm |
Water(KF) | 4.5%-6.5% | 5.96% |
Sulphated ash | ≤0.1% | 0.04% |
Assay(anhydrous substance) | 99.0%~101.0% | 100.0% |
Limit on residual solvents Acetone Ethanol Chloroform Ethyl acetate Tetrahydrofıran | ≤5000ppm ≤ 5000ppm ≤60ppm ≤5000ppm ≤5000ppm | Not found 192ppm Not found 80ppm Not found |
Conclusion | Analysis according to EP | |
Stability
Pramipexole dihydrochloride monohydrate is a generally used dopamine receptor agonist. Its stability depends on several factors, including storehouse conditions and expression. Generally speaking, when stored duly, it's stable.
Temperature it should be stored at room temperature. Avoid exposure to extremely high or low temperatures as it may affect the stability of the emulsion.
moisture The presence of moisture can impact its stability. It's important to cover the drug from inordinate humidity as it may beget declination. insure that the vessel is duly sealed to help humidity doorway.
Light it should be defended from the direct sun. Dragged exposure to direct sun or artificial light sources may lead to emulsion declination. Keep the drug in its original opaque vessel or store it in a light-resistant vessel.
Storage
The storage conditions are as follows:
Temperature Store it at room temperature. Avoid exposure to extremely high or low temperatures.
the moisture it from inordinate moisture by icing the vessel is tightly sealed to help humidity doorway. It's stylish to store the drug in an terrain with low relative moisture.
Light Avoid direct sun exposure for it. Dragged exposure to direct sun or artificial light sources may beget emulsion declination. Store the drug in its original opaque vessel or use a light-resistant vessel.
Packaging Keep it in its original packaging, which is generally designed to give optimal stability and protection.
Storage position Store it in a dry, clean, light-defended, and well- voiced area. Avoid storing it in damp or sticky surroundings, and don't place it in places like the kitchen or restroom.
Packing & Shipping
Quilting 1kg/ antipode bag; 5kg/ tinderbox; 25kg/ fiber barrel; or packing as your request.
CustomizationCustomized totem; tailored packaging; Graphic customization
Shipping:
Item | Quantity | ETA time | Shipping Method |
By Courier | ≤50kg | 7-15days | Fedex, DHL,UPS,TNT,EMS ect. Fast and convenient |
By Air | 50kg~200kg | 3-5days | Fast and cheap |
By Sea | Large quantity | 20-35days | Cheapest way |
Payment Term
Why Choose Xi'an Yihui?
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Our Advantage
Rich experience: we have 13 Years of professional experience;
Customers all over the world: sell to more than 100 countries;
Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition, and functional food.
Price advance: low MOQ with competitive price;
Quality certification: ISO; Halal; Kosher certified
After-sales service: Professional team 7*24 hours customer service.
In conclusion
In summary, Xi'an Yihui company as a professional Pramipexole dihydrochloride monohydrate manufacturer, has strong technical strength and advanced production equipment and is committed to providing customers with high-quality, efficient, and reliable drug raw materials. if you need it, pls feel free to contact us any time. we will reply you asap.
Our contact information:
E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
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