We supply Mitotan

We're proud to offer Mitotan API, a high- quality active pharmaceutical component used in the treatment of certain kinds of cancer. Mitotan is a drug that works by reducing the product of certain hormones that can beget the growth of cancer cells. Our product is manufactured under strict quality norms to insure chastity and efficacity. It's available in different forms to suit the individual requirements of cases. Whether you're a pharmaceutical manufacturer or a medical professional looking for dependable mitotan  suppliers, we're then to meet your requirements and help you give effective cancer treatment.

What is Mitotan ?

Mitotane API, also known as Lysodren, is a important drug used in the treatment of certain types of cancer, particularly adrenal cancer. This drug serves as an adrenal toxic, meaning it attacks the cells within the adrenal gland and reduces their capability to produce hormones.

As an API( Active Pharmaceutical component), it is used as a base for formulating specifics that are suitable for patient use. This emulsion is known for its capability to inhibit the product of cortisol, a hormone that's frequently overproduced in cases with adrenal cancer. By reducing cortisol product, it can help shrink excrescences and ameliorate overall case issues.

While it is a largely effective drug, it must be used with care due to its eventuality to beget side goods. Some of the most common side goods associated with this drug include vomiting, diarrhea, and loss of appetite. To alleviate these side goods, croakers

will cover cases nearly and acclimate lozenge consequently.

Overall, it has proved to be a precious tool in the battle against adrenal cancer. Its capability to reduce cortisol product and shrink excrescences has helped numerous cases achieve better issues. As with any drug, its use should be nearly covered by a healthcare professional to insure safe and effective treatment.

Basic Information

Product Name: Mitotan

CAS: 53-19-0

MF:C14H10Cl4

MW:320.04

EINECS:200-166-6

MDL No.:MFCD00000850

Melting point:77-78 °C(lit.)

Boiling point:405.59°C (rough estimate)

Structural formula:

Origin: China

Delivery Time: in stock

Technical Specification

Package: 1kg;25kg; or according to your demands

Storage: Preserve in tight,light-resistant containers in cool place

Shelf Life:Powder: 2 years

Application

Mitotane is an API( Active Pharmaceutical component) used in the treatment of adrenal cortical melanoma – a rare and aggressive form of cancer. It operates by destroying the cells of the adrenal cortex gland, which is responsible for producing certain hormones. Mitotane can be used alone or in combination with other specifics.

Mitotan API is administered orally in tablet form and has been shown to be veritably effective in reducing the size of the adrenal cortical excrescence. it workshop by breaking down the cells of the adrenal cortex, which causes the excrescence to shrink. It also prevents the product of cortisol, which helps to control the symptoms of adrenal cortical melanoma.

The use of Mitotan has been known to beget some adverse responses, similar as nausea, puking, and diarrhea. still, these side goods are generally temporary and can be managed with drug.

It's necessary to conduct routine blood tests to cover the situations of the drug in the body and to insure that the Mitotane remedy is administered safely. The cure of Mitotan will depend on the individual case's health and the stage of the complaint.

Overall, it is a pivotal drug in the treatment of adrenal cortical melanoma and has been shown to be effective in reducing the size of the excrescence and controlling the symptoms of the complaint. Its use must be carried out under the guidance of a good healthcare professional.

Pharmacological action

The structure of Mitotane API is analogous to that of the germicides DDT and DDD. It can widely beget atrophy and necrosis of the zona fasciculata and zona reticularis cells of the adrenal cortex, but does n't affect the zona glomerulosa, so aldosterone stashing is n't affected. After taking the medicine, hydrocortisone and its metabolites in the blood and urine drop fleetly, and the situations of adrenal cortical hormones and their metabolites in the body drop fleetly. It's suitable for the treatment of inoperable, functional andnon-functional adrenal cortical melanoma, adrenal excrescences, Kupffer's pattern caused by adrenal hyperplasia, adrenal cortical hyperplasia, adjuvant treatment after cortical melanoma surgery, and hypercortisolism caused by excrescences.

Biological activity

it is an antineoplastic agent used to treat adrenocortical cancer.

in vitro studies

In the mouse TalphaT1 cell line, Mitotane inhibits the expression and stashing of TSH, blocks the response of TSH to TRH, reduces cell viability, and induces apoptosis. In pituitary TSH- concealing mouse cells, Mitotane does n't intrude with thyroid hormones but directly reduces secretory exertion and cell viability. Mitotane induces adrenocortical necrosis, mitochondrial membrane damage, and unrecoverable list to the protein CYP. Mitotane( 10- 40 μM) inhibits rudimentary and cAMP- convinced cortisol stashing but does n't beget cell death. Mitotane exhibits inhibitory goods on rudimentary StAR and P450scc proteins. Mitotane( 40μM) significantly reduced the mRNA situations of StAR, CYP11A1 and CYP21. Mitotane( 40μM) nearly fully neutralizes the induction of STAR, CYP11A1, CYP17 and CYP21 mRNA by 8- bromocyclic adenosine monophosphate. In the S phase of H295R cells, the combination of Mitotane and gemcitabine showed enmity and obtruded with gemcitabine- intermediated inhibition of the cell cycle.

in vivo studies

In rats, Mitotane( 60 mg/ kg) significantly reduced adrenal mitochondria and microsomal “P- 450” and microsomal proteins by 34%, 55%, and 35%.

Packing & Shipping

Packing: 1kg/foil bag;5kg/carton;25kg/fiber drum; or packing as your request.

Customization: Customized logo; Customized packaging; Graphic customization

Shipping:

Payment Term

Why Choose Xi'an Yihui?

Customer feedback

Xi'an Yihui certificates

Xi'an Yihui Factory & Warehouse

Where to buy?

To sum up, Xi'an Yihui Company as a professional Mitotan API manufacturer of Tianeptine Sodium Salt, with high-quality products, a high level of research and development capabilities, advanced production equipment and technology, perfect after-sales service, and other advantages, is the customer choice of the ideal partner.

if you need Mitotane API, pls feel free to contact us at any time. we will reply to you ASAP.

Our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937