We supply Methyldopa API

Methyldopa API that we proudly supply for use in colorful medicine phrasings. This active pharmaceutical component is used primarily to treat hypertension, as it works by reducing the quantum of certain chemicals in the body that beget blood vessels to constrict. As a trusted supplier of Methyldopa powder, we insure that our guests admit high- quality, medicinal- grade material that meets all necessary norms and regulations. With our commitment to quality and client satisfaction, you can count on us to deliver it you need to produce safe, effective medicinal products. Get in touch moment to learn further about our products and services.

What's Methyldopa?

Methyldopa, also known as α methyldopa,L-(-)-α-Methyldopa,Methyldopa Sesquihydrate. it is a drug used to treat high blood pressure. it is an established and effective medicine that has been used for numerous decades. It was first introduced in the 1960s and snappily came a popular choice for treating high blood pressure. The medicine is available in different forms, including tablets, injection, and saccharinity. it is approved for use by the FDA and is available only by tradition. The drug is generally taken by mouth, generally two to three times a day, depending on the existent's blood pressure situations. it is the active pharmaceutical component in the drug. API is the pure, active element of a medicine that's responsible for its remedial effect. The API must be precisely designed and manufactured to insure its efficacity and safety. The product involves several way, including the birth of the active component from natural sources. In the case, it's synthesized from L- tyrosine, an amino acid set up in numerous foods. The product  is carried out in agreement with strict quality control norms. In conclusion, it is a vital element of the antihypertensive drug . The product  is precisely covered and regulated to insure its safety and efficacity, making it an essential element of ultramodern drug.

Basic Information

Product Name: Methyldopa

CAS:555-30-6

MF:C10H13NO4

MW:211.22

EINECS:209-089-2

MDL No.:MFCD00004186

Structural formula:

Purity: 99%+

Origin: China

Application: Anti hypertensive

Delivery Time: in stock

Technical Specification

Package: 1kg; 25kg

Storage conditions: keep tightly closed, store in a cool dry place.

Antihypertensive drugs

Methyldopa API, an antihypertensive drug, α Receptor agonists are commonly used in the form of tablets. This product is a type of excitatory vascular motor center α- Receptors, thereby inhibiting the sympathetic nervous system, produce a hypotensive effect, accompanied by a slowing heart rate, reduced cardiac output, dilation of small arteries, significant reduction in peripheral vascular resistance, and no significant reduction in cardiac output during long-term use. Clinically used for moderate to severe or malignant hypertension, especially suitable for patients with secondary hypertension, gestational hypertension, heart failure with hypertension, coronary heart disease with hypertension, and elderly hypertension.

Character

This product is a white or almost white crystalline powder; Odorless. This product is slightly soluble in water, slightly soluble in ethanol, extremely soluble in ether, and easily soluble in dilute hydrochloric acid. The specific rotation is -25° to -30°.

Pharmacological action

This product is an inhibitor of aromatic amino acid decarboxylase. only its left isomer  has antihypertensive activity in humans, while the racemic form (DL)- α- Methyldopa requires twice the dosage to achieve the same antihypertensive effect. Its antihypertensive effect may be attributed to its active metabolites β- The inhibitory effect of methylnorepinephrine stimulation on the central nervous system β Receptors and pseudo neurotransmitters reduce plasma renin activity, thereby lowering arterial blood pressure. Methyldopamine can reduce the concentrations of serotonin, dopamine, norepinephrine, and methylepinephrine in tissues. It has no direct impact on heart function and usually does not reduce glomerular filtration rate, renal blood flow, and filtration fraction. The cardiac output remains unchanged at normal heart rate, and some patients experience a decrease in heart rate. During the treatment process, plasma renin activity decreases. it can lower lying and standing blood pressure, and orthostatic hypotension is rarely observed. Low blood pressure during rare daytime exercise.

What is the application?

This product is a antihypertensive drug.

Levodopa is a B-receptor blocking cardiovascular drug that has good therapeutic effects on moderate primary and renal hypertension.

Production methods

Methylation of vanillin with dimethyl sulfate to resveratrol, followed by condensation with nitroethane to obtain 1- (2-nitropropenyl) -3 ', 4' - dimethoxybenzene, reduced with iron powder and hydrolyzed to form 3 ', 4' - dimethoxyphenylacetone, followed by cyclization, ring opening, and hydrolysis reactions to obtain DL methyldopa, which is then separated into a left handed compound to obtain methyldopa

Side effect

Gastrointestinal reactions include nausea, vomiting, and loss of appetite, which can occur in the early stages of treatment. After 3 months of medication, symptoms such as restlessness, insomnia, hallucinations, and other mental symptoms may occur. In addition, there may also be orthostatic hypotension, arrhythmia, and involuntary movements.

Indications

1. Tremor paralysis: The effect is better for patients with mild to moderate conditions, but worse for severe or elderly patients.

2. Liver coma: can make the patient sober and improve symptoms. Liver coma may be related to abnormalities in the central neurotransmitter dopamine. After taking it, it can improve central function and be effective.

3. Some people believe that levodopa can improve the brain's tolerance to ammonia.

Why Choose Xi'an Yihui?

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Xi'an Yihui Factory & Warehouse

Our Advantage

Rich experience: we have 13 Years of professional experience;

Customers all over the world: sell to more than 100 countries;

Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition, and functional food.

Price advance: low MOQ with competitive price;

Quality certification: ISO; Halal; Kosher certified

After-sales service: Professional team 7*24 hours customer service.

In conclusion

In summary, Xi'an Yihui company as a professional Methyldopa API manufacturer has strong technical strength and advanced production equipment and is committed to providing customers with high-quality, efficient and reliable drug raw materials. if you need Methyldopa powder, pls feel free to contact us any time. we will reply you ASAP.

Our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937