We supply Abiraterone Acetate API

We've a dependable force of Abiraterone Acetate API. This high- quality product is used in the treatment of prostate cancer and has shown promising results in clinical trials. Our Abiraterone is manufactured under strict quality control measures to insure chastity and energy. It's handed in bulk amounts and competitively priced to meet the requirements of our guests. Working with us means you can anticipate timely delivery, responsive client service, and a commitment to the loftiest norms of quality and compliance. Choose us as your supplier of Abiraterone Acetate and you will not be dissatisfied.

What is Abiraterone Acetate API

Abiraterone Acetate Powder was originally developed in collaboration with the UK Cancer Institute and BTG, and latterly transferred global development and listing rights to Cougar Biopharmaceutical Company( now a attachment of Johnson & Johnson) in the United States. Acetic acid abiraterone was first approved for trade in the United States on April 28, 2011, under the trade name Zytiga. It's an oral tablet, 250 mg, used in combination with prednisone to treat castration resistant prostate cancer( cRPC) that can not be controlled by docetaxel.

Basic Information

Abiraterone acetate

CAS:154229-18-2

MF:C26H33NO2

MW:391.55

EINECS:620-314-7

MDL No.:MFCD00934213

Purity: 99%+

Origin: China

Stability: Stable

Structural formula:

Melting point 127-130 ℃

Boiling point 506.7 ± 50.0 ℃ (Predicted)

Density 1.14 ± 0.1 g/cm3 (Predicted)

Solubility in chloroform (small amount), DMSO (small amount), methanol (small amount)

Technical Specification:

Packaging: 1kg/bag; 25kg/drum

Storage conditions: room temperature, light proof, moisture-proof, sealed and dry

Transportation conditions: Transportation at room temperature

Security information

UN Number: Non dangerous goods (for reference only, please verify)

UN Transport Name: Non Hazardous Goods (for reference only, please verify)

United Nations Hazard Classification: Non Hazardous Goods (for reference only, please verify)

Packaging category: Non hazardous goods (for reference only, please verify)

Packaging method: Pack according to the manufacturer's recommended method, such as an open steel drum. An ordinary wooden box outside the ampoule bottle. Screw mouth glass bottles, iron cap pressure mouth glass bottles, plastic bottles or ordinary wooden boxes outside metal barrels (cans), etc.

Marine pollutants (yes/no): no

What is the application of Spinosad powder?

Abiraterone acetate api  is a CYP17 inhibitor that can be used in combination with prednisone to treat prostate cancer patients who have previously received docetaxel chemotherapy for metastasis. it is a precursor chemical that can be converted into abiraterone upon entry into the body. The latter is an inhibitor of androgen biosynthesis that exerts therapeutic effects by inhibiting the activity of CYP17 enzyme, thereby inhibiting androgen biosynthesis.

Research reagents are widely used in molecular biology, pharmacology, and other scientific research fields. it is converted into abiraterone in the body, an inhibitor of androgen biosynthesis that inhibits Chemicalbook17 α- Hydroxylase/C17,20-lyase (CYP17). This enzyme is expressed in testicular, adrenal, and prostate tumor tissues and is required for androgen biosynthesis.

Mechanism of action

Abiraterone Acetate Powderis an orally effective CYP17 inhibitor that metabolizes into abiraterone in the body and exerts its effects on 17 α- The inhibitory activity of hydroxylase/C17, 20-lyase (CYP17) is 10-30 times higher than that of ketoconazole. Clinical studies have shown that it can significantly reduce prostate specific antigen (PSA) levels in prostate cancer patients and help shrink tumors, extending the lifespan of advanced prostate cancer patients by several years. it is a precursor drug of Abiraterone, which targets the androgen receptor signaling pathway. it is a highly selective and potent inhibitor of cytochrome oxidase CYP17, and its inhibitory effect is irreversible, 10-30 times stronger than the non selective inhibitor ketoconazole.

Physical and chemical properties

Acetate abiraterone is a CYP17 inhibitor suitable for use in combination with prednisone in the treatment of refractory prostate cancer patients who have previously received docetaxel containing chemotherapy for metastasis and castration.

Biological activity

Acetate abiraterone (CB7630) is the acetate form of Abiraterone, a steroid cytochrome CYP17 inhibitor with an IC50 of 72 nM in cell-free assays. it is an oral inhibitor of androgen biosynthesis.

In vitro research

Abiraterone only exhibits good chelation with heme iron in SM1. it blocks the synthesis of androgens by inhibiting CYP17A1. it will also block 3 β- Hydroxylated steroid dehydrogenase (3 β HSD, 3 β HSD is an enzyme that relies entirely on the synthesis of biologically active androgens. it inhibits the conversion of DHEA into  Abiraterone inhibits C17,20 lyase, with an IC50 of 5.8nM in rat testicular microsomes. it significantly inhibits testosterone secretion (-48%) and in turn increases LH concentration (192%). it inhibits the in vitro proliferation of AR Chemicalbook positive prostate cancer cells and the expression of AR regulatory genes, which may be caused by AR antagonistic effects in addition to steroid generation inhibition.

In vivo research

Abdominal injection was administered to rats, and it was rapidly deacetylated in vivo. CB7630 (AbirateroneAcetate) is a proacetate drug that can inhibit circulating testosterone below detection levels and significantly reduce the weight of androgen sensitive organs. it is well tolerated, with an average elimination half-life of 27.6 hours. Preclinical studies conducted in mice have shown that it inhibits CYP17, reduces androgen production, and can lead to weight loss in the prostate, testes, and seminal vesicles.

Contact information

as a professional Abiraterone acetate apimanufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make it stand out in the market competition and win more customer trust and support. if you need Abiraterone acetate powder, pls feel free to contact us any time. we will reply you asap.

our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937