We supply Mesalazine API

We specialize in supplying Mesalazine API, which is a medication used to treat inflammatory bowel disease, such as ulcerative colitis and Crohn's disease. As an active pharmaceutical ingredient, it works by reducing inflammation in the colon. Our Mesalazine is of the highest quality and purity, meeting all international standards. We strive to provide our clients with the best service and guarantee timely delivery. Trust us to be your reliable partner in the pharmaceutical industry. Contact us today for more information on our Mesalazine powder products.

What is Mesalazine?

Mesalazine , also known as 5- aminosalicylic acid, is an organic emulsion with the chemical formula C7H7NO3. It's an active component in the treatment of ulcerative colitis with SASP. It has a significant inhibitory effect on inflammation of the intestinal wall. It can inhibit the conflation of prostaglandins that beget inflammation and the conformation of the seditious middleman leukotriene, thereby significantly inhibiting inflammation of the intestinal mucosa. It can inhibit the conflation of prostaglandins in a cure-dependent manner, reducing the release of PGE2 in the mortal colon mucosa.

Basic Information

Product Name: Mesalazine；5-Aminosalicylic acid

CAS NO.: 89-57-6

MF: C7H7NO3

MW: 153.14

EINECS: 201-919-1

MDL No.: MFCD00007877

Purity: 99%+

Origin: China

Stability: Stable

Structural formula:

Melting point: 275-280 ℃ (dec.) (lit.)

Boiling point: 276.03 ℃ (roughestimate)

Density: 1.3585 (roughestiChemicalbookmate)

Vapour pressure: 0Paat25℃

Refractive index: 1.5500 (estimate)

Flash point: 279-281 ℃

Solubility: Soluble in hydrochloric acid, slightly soluble in hot water, micro bath in cold water or ethanol.

Technical Specification:

Packaging25kg/bag; 25kg/drum

Storage conditions: room temperature, light proof, moisture-proof, sealed and dry

Transportation conditions: Transportation at room temperature

What is the application of Mesalazine API?

Dye intermediates.Mesalazine API is an important pharmaceutical and dye chemical raw material, and is also the main raw material for the treatment of chronic colitis drug sulfasalazine. It itself has similar therapeutic effects. 5-aminosalicylic acid, due to its active reactive groups of hydroxyl and carboxyl groups on the ring, can undergo various reactions. Therefore, in the dye industry, it can be used to manufacture various high-quality reactive dyes. Also used in the manufacturing of photosensitive paper.

5-aminosalicylic acid, also known as mesalazine powder, can be used as a chemotherapeutic drug for ulcerative colitis and has a significant inhibitory effect on inflammation of the intestinal wall; It can inhibit the synthesis of prostaglandins that cause inflammation and the formation of the inflammatory mediator leukotriene, thereby significantly inhibiting inflammation of the intestinal mucosa. The effect is better on the connective tissue of the inflamed intestinal wall. Used for ulcerative colitis, ulcerative proctitis, and Crohn's disease.

It is a peroxidase substrate suitable for ELISA analysis. The substrate generates a brown soluble end product, which can be read at 450nm by spectrophotometry. Adding 3NNaOH can terminate the reaction and then read at 550nm.

Security information

Category: Toxic substances

Toxicity classification: Poisoning

Acute toxicity: intraperitoneal mouse LD50: 5000 mg/kg; Oral administration - mouse LDL0:313 mg/kg

Flammability hazard characteristics: flammable; Burning produces toxic nitrogen oxide smoke

Storage and transportation characteristics: warehouse ventilation, low-temperature drying

Extinguishing agent: dry powder, foam, sand, carbon dioxide, atomized water

Dangerous goods label: Xi

Hazard category code: 36/37/38-52/53

Safety instructions: 26-36-24/25-61-37/39

WGK Germany: 2

RTECS number: VO1400000

F: 8-10-23

Autoignition temperature: 280 ° C

TSCA: Yes

Hazard level: IRRITANT

Customs code: 29225000

Toxic Substance Data: 89-57-6

Toxicity: LD50orallyinRabbit: 2800mg/kg LD50dermalRate>5000mg/kg

Production methods

Method 1:

After mixing salicylic acid with water, slowly add a mixture of 68% nitric acid and glacial acetic acid at 50 ℃ and stirring. Heat up again to 70-80 ℃ for reaction. Pour the reaction solution into water and place it at 5 ℃. Filter and recrystallize the filter cake with hot water to obtain solid 5-nitrosalicylic acid with a yield of 40%. Add iron powder to hydrochloric acid solution at 60 ℃. After heating and boiling, add 1/4 of 5-nitrosalicylic acid. After vigorous stirring, alternate the addition of other nitro compounds and iron powder in batches. Add and react at 102 ℃. Adjust to strong alkalinity with 50% sodium hydroxide while hot, and filter. Wash the filter cake with hot water, combine the filtrate and washing solution, add insurance powder, and acidifie with 40% sulfuric acid to a pH value of 4. Cool, filter, dry, dissolve it in hot water with sodium bisulfite, and boil it with activated carbon. Hot filtration, wash the filter cake with a small amount of hot water. Combine the filtrate and wash solution and place at 5 ℃. Filter and collect crystals, wash thoroughly with ice water, dry to obtain white needle shaped  crystals with a melting point of 278 ℃ (decomposition).

Method 2:

Salicylic acid is nitrated to obtain 5-nitrosalicylic acid, which then reacts with methylsulfonyl chloride to protect the phenolic hydroxyl group. It is then hydrogenated to reduce the nitro group to an amino group, and finally hydrolyzed to obtain mesalazine.

Method 3:

Aniline is diazotized to obtain diazonium salt, which is added to a solution of salicylic acid, sodium carbonate, and 40% sodium hydroxide. It is vigorously stirred at 0-6 ℃ while maintaining a pH value of 8. Filter, wash with saturated salt water, and press dry. Dissolve in a 40% sodium hydroxide solution and add insurance powder at 80-85 ℃. After the solution completely fades, remove aniline by steam distillation and filter. Adjust the filtrate to a pH value of 6-6.5 with concentrated hydrochloric acid and leave it overnight. Filter, wash with cold water, dissolve the dried crude product in water, add concentrated hydrochloric acid dropwise until dissolved, then add activated carbon and heat until boiling. Filter, cool, and adjust to a pH value of 2-3 with dilute sodium hydroxide. Filter, wash with cold water, vacuum dry at room temperature to obtain a gray white solid of mesalazine, with a melting point of 278 ℃ (decomposition) and a total yield of 45.9%.

Method 4:

Mix aminophenol and an appropriate amount of catalyst at CO2 pressure of 2.0-3.0 MPa and 130-190 ℃. Cool to room temperature, add water and insurance powder, and stir. Cool to 0-3 ℃, filter out insoluble substances, and wash with water. Combine the washing solution and filtrate, adjust to a pH value of 3-4 with hydrochloric acid, filter, wash with water, and obtain crude mesalazine. Add water, sodium bicarbonate, and sodium bisulfite to the crude product, heat until fully dissolved at 50-60 ℃, then add activated carbon and boil. Filter, cool, and adjust the dilute hydrochloric acid to a pH value of 3.5. Filter, wash, and dry to obtain a gray white high-quality product with a yield of 91.1% and a content of 99.2%.

Contact information

 Xi 'an Yihui Company as a professional manufacturer of Mesalazine API, with high-quality products, high level of research and development capabilities, advanced production equipment and technology, perfect after-sales service and other advantages, is the customer choice of the ideal partner.

if you need Mesalazine powder, pls feel free to contact us any time. we will reply you ASAP.

Our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937