We supply Exemestane API

Our company is proud to supply high- quality Exemestane API. It is a important aromatase asset, generally used in the treatment of bone cancer in postmenopausal women. It is produced using advanced manufacturing processes and strict quality control measures to insure its chastity and effectiveness. With our commitment to excellence, you can trust us to give you with the stylish Exemestane available on the request. communicate us moment to learn further about our product and how it can profit your exploration and medical requirements.

What's Exemestane  powder?

Exemestane powder, also known as 6- methylene, is an organic emulsion with the chemical formula C20H24O2. It's a white to pale unheroic crystalline greasepaint that's answerable in methanol but undoable in water. It's ananti-tumor medicine. It is an unrecoverable steroid aromatase asset with a structure analogous to its substrate, natural androstenedione. Depriving estrogen by inhibiting aromatase is an effective and voluntary system for the treatment of hormone dependent bone cancer in postmenopausal Chemicalbook women. It's used for advanced bone cancer in natural or artificial postmenopausal women who haven't progressed after tamoxifen treatment.

Basic Information

Product Name: Exemestane

CAS: 107868-30-4

MF:C20H24O2

MW:296.4

EINECS:643-090-2

MDL No.:MFCD00866994

Structural formula:

Application: Anticancer

Origin: China

Delivery Time: in stock

Technical Specification

Package: 100g ;1kg; 5kg or according to your demands

Storage conditions: Preserve in tightly closed container between 2-8 ℃

Shelf Life: 24 months

Function and Use

Exemestane powder is a steroid aromatase inactivator, and its structure is analogous to the natural substrate of aromatase, androstenedione, making it a mock substrate of aromatase. Due to the fact that estrogen in postmenopausal women is substantially produced by the conversion of androgens( produced by the adrenal cortex) through the action of aromatase in supplemental apkins, this product irreversibly binds to the active point of aromatase and inactivates it, thereby significantly reducing the position of estrogen in the blood rotation of postmenopausal women. This product has no significant effect on the biosynthesis of adrenal cortical hormones. Indeed when the attention is 600 times advanced than the attention that inhibits the action of aromatase, it has no significant effect on other enzymes in the corticosteroid product pathway. The oral immersion of this product is rapid-fire, and the immersion is affected by food. The oral bioavailability is 42. Postmenopausal women have a advanced immersion rate of medicines than healthy subjects. Cases reach the peak blood attention of the medicine 2- 4 hours after oral administration, with an average peak time of1.2 hours, which is shorter than healthy subjects(2.9 hours). It substantially binds to nascence 1-acidic glycoproteins and proteins, with a total protein list rate of 90. substantially delivered by the liver, the metabolite is inactive 17- hydroexemestan, with a half- life of 24 hours for concurrence. substantially excreted through urine or feces, each account for 42 of the drug lozenge.

Pharmacological action

The growth of bone cancer cells can depend on the presence of estrogen. The estrogen( estrone and estradiol) in the womanish postmenopausal cycle is mainly converted from the androgen( androstenedione and testosterone) in the adrenal gland and ovary by aromatase in the supplemental kerchief. Inhibiting aromatase to help estrogen product is an effective and picky treatment for postmenopausal hormone dependent bone cancer. Exemestane powder is an unrecoverable steroid aromatase inactivator, structurally similar to the natural substrate of the enzyme androstenedione. It's a mock substrate of aromatase and can be inactivated by unrecoverable list to the active point of the enzyme( also known as" tone destructive inhibition"), significantly reducing estrogen situations in the bloodstream of postmenopausal women. still, it has no significant effect on the biosynthesis of corticosteroids and aldosterols in the adrenal gland. When the attention of aromatase inhibition is 600 times advanced, it does not have a significant effect on other enzymes in the steroid product pathway.

Synthesis

Using androsten-4-en-3,17-dione (2) as raw material, 6-methylene-4-en-3,17-dione (3) was synthesized by condensation with triethyl orthoformate, N-methylaniline, and 40% formaldehyde solution. Then, 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) was oxidized to obtain 1. In the oxidative dehydrogenation reaction, adding a certain amount of weak acid can shorten the reaction time from 15 hours to 8 hours, and the yield can be increased from 47% to 62%. This method has mild reaction conditions, simple separation, and a total yield of 45%. The synthesis route is as follows:

Adverse reactions

The main adverse reactions of this product include nausea, dry mouth, constipation, diarrhea, dizziness, insomnia, rash, fatigue, fever, edema, pain, vomiting, abdominal pain, increased appetite, weight gain, etc. Secondly, literature reports also include hypertension, depression, anxiety, difficulty breathing, cough, etc. Other abnormalities include decreased lymphocyte count and abnormal liver function indicators such as alanine transferase.

Payment Term

Why Choose Xi'an Yihui?

Customer feedback

Xi'an Yihui certificates

Welcome to Xi'an Yihui Factory

Contact Us:

Yihui takes pride in being a trusted Exemestane powder manufacturer and supplier. To acquire this groundbreaking product or discuss your specific requirements, contact us immediately at sales@yihuipharm.com. Rest assured, with Yihui, you're accessing a product of unparalleled quality, backed by certifications that underscore our commitment to excellence in the global market.