We supply 5-Flucytosine

We're pleased to offer 5-Flucytosine, a potent antifungal drug used in the treatment of colorful fungal infections. Our high- quality product is manufactured using advanced technology and is available in colorful forms including tablets and capsules. It workshop by snooping with fungal DNA conflation and precluding its growth. It's frequently used in combination with other antifungal medicines to achieve better results. Our product is backed by rigorous quality control measures icing its chastity and effectiveness. With our timely delivery and competitive pricing, we're committed to meeting your drug needs.

What is 5- Flucytosine?

5- Flucytosine, also known as Fluorocytosine, 5- FC, is a synthetic antifungal agent that's generally used in the treatment of systemic fungal infections. It works by inhibiting the conflation of fungal DNA and RNA, thereby dismembering the cell division process and causing the death of the fungal cells.

it is a prodrug that's converted into the active form, 5- fluorouracil( 5- FU), by fungal cytosine deaminase. This enzyme is only present in fungal cells and not in mortal cells, which makes 5- FC a picky antifungal agent with low toxin to humans.

it is generally administered orally and it's fleetly absorbed from the gastrointestinal tract. It has a short half- life of about 2.5 hours and is primarily excreted in the urine. It's effective against a broad range of fungal species, including Candida, Cryptococcus, and Aspergillus.

Some of the common side effects associated with 5- FC include nausea, puking, diarrhea, and bone gist toxin. It can also beget liver and order damage in rare cases. thus, it's important to cover the case's liver and order function during treatment.

it is frequently used in combination with other antifungal agents, similar as amphotericin B or azoles, to ameliorate the efficacity and reduce the threat of resistance. It's also used for prophylaxis in immunocompromised cases who are at high threat of fungal infections.

In summary, 5- Flucytosine is a potent antifungal agent that's used in the treatment of systemic fungal infections. It has a unique medium of action and low toxin to humans, which makes it an important medicine in the magazine against fungal infections.

Chemical parcels:  White or out-white crystalline greasepaint, odorless or slightly odorous. Slightly answerable in water, with a solubility of 1.2( 20 °C), slightly answerable in ethanol; nearly undoable in chloroform and ether; fluently answerable in dilute hydrochloric acid or dilute sodium hydroxide result. Stable at room temperature, precipitates chargers when cooled, and incompletely converts to 5- fluorouracil when hotted.

Basic Information

Product Name: 5-Flucytosine; Fluorocytosine

CAS:2022-85-7

MF: C4H4FN3O

MW: 129.09

EINECS:217-968-7

MDL No.: MFCD00006035

Melting point: 298-300 ℃(dec.) (lit.)

Structural formula:

Origin: China

Delivery Time: in stock

Technical Specification

Package: 1kg; 25kg or according to your demands

Storage: Preserve in tight,light-resistant containers in cool place

Shelf Life: 2 years

Function

5-Flucytosine is an antifungal drug primarily used to treat infections caused by certain fungal organisms, particularly Cryptococcus neoformans and Candida species. Its medium of action involves the following

Inhibition of Nucleic Acid conflation: it is a pyrimidine analog that interferes with fungal RNA and DNA conflation. It gets converted inside the fungal cell to 5- fluorouracil, which also inhibits thymidylate synthase, an enzyme pivotal for DNA conflation.

Selective Toxicity: While it affects fungal cells, mortal cells are less susceptible because they do n't convert 5- flucytosine to 5- fluorouracil effectively.

Combination remedy : It's frequently used in combination with other antifungal agents, similar as amphotericin B, to enhance efficacity and reduce the threat of resistance.

Overall, it is an important tool in the treatment of serious fungal infections, particularly in immunocompromised cases.

Application

Antifungal medicine. substantially used for skin and mucosal candidiasis, candidal endocarditis, candidal arthritis, cryptococcal meningitis and chromomycosis. Blood counts should be checked regularly during drug. Use with caution in cases with hematological conditions and pregnant women with liver and order dysfunction; contraindicated in cases with severe renal insufficiency.

This product is used as the first choice medicine for the treatment of severe systemic white candidal and cryptococcal infections abroad( included in the" United States Pharmacopeia"( 19th edition)), and is used for the treatment of fungal meningitis, fungal respiratory tract infections and black fungal conditions.

Antifungal medicine, has good inhibitory goods on Candida, Cryptococcus, and Trichoderma, and also has goods on some Aspergillus, as well as Cladosporium and Bottle Fungus that beget skin fungal conditions. It has no effect on other fungi and bacteria

Used in the study of trimethoprim( TMP) biosynthesis

Used in the treatment of fungal infections caused by cryptococci and Candida, similar as fungal sepsis, endocarditis, meningitis, and lung and urinary tract infections.

Side effect

Fluorocytosine can beget several side effects, some of which may be serious. Common side effects include

Bone Gist repression This can lead to anemia, leukopenia( low white blood cell count), and thrombocytopenia( low platelet count).

Gastrointestinal Issues Nausea, puking, diarrhea, and abdominal pain are possible.

Hepatotoxicity Liver function abnormalities may do, leading to elevated liver enzymes.

Dermatological responses Rash or other skin responses can develop.

Neurological goods Symptoms like headache, dizziness, or confusion may do in some cases.

Renal toxin Although lower common, it can affect order function.

Regular monitoring of blood counts and liver function is recommended during treatment to manage and alleviate these implicit side effects. Always consult a healthcare provider for individualized medical advice.

Production method

5- fluorouracil is attained by chlorination, ammoniation and hydrolysis. 1. Chlorination Add 5- fluorouracil and phosphorus oxychloride to the chlorination pot, stir, and add- dimethylaniline at a temperature below 20 °C. After the addition is completed, heat to about 110 °C and reply for 2 hours. Cool to room temperature, put in ice swab water to thaw, maintain 15 °C and stir for 1 hour. Sludge and wash with water to gain 2,4- dichloro-5-fluoropyrimidine. 2. Ammoniation Dissolve 2,4- dichloro-5-fluoropyrimidine in ethanol, stir, and add ammonia water at a temperature below 35 °C. After the addition is completed, cool to 25 °C and reply for 3 hours, recover ethanol under reduced pressure to blankness, add water, stir and heat to 20 °C. Sludge, wash the chargers with water, and dry to gain 4- amino-2-chloro-5-fluoropyrimidine. 3. Hydrolysis Mix 4- amino-2-chloro-5-fluoropyrimidine and hydrochloric acid, stir and heat to 90- 95 ℃, reply for 2h, also concentrate to blankness under reduced pressure, add water to dissolve chargers, and add actuated carbon for decolorization. Sludge, acclimate the pH of the filtrate to 7- 8 with ammonia water, and leave overnight. Sludge, wash the chargers with water, and purify to gain flucytosine. The total yield is 50. The starting material of this system is the anticancer medicine fluorouracil( 51-21-8). The precursor of fluorouracil, 2- methoxy-4-hydroxy-5-fluoropyrimidine, can also be used as a raw material to prepare flucytosine through chlorination, ammoniation, and hydrolysis, with a yield of 70. Add the below precursor to toluene, also add dimethylaniline, heat to 50- 60 ℃, and add phosphorus oxychloride dropwise. also reply at 105- 110 ℃ for 3h. Cool to room temperature, add the response result to a admixture of toluene and water, and stir at 25- 40 ℃. Separate the toluene subcaste, prize the water subcaste with toluene, combine the uprooted liquid with the toluene subcaste, first recover the toluene under reduced pressure, and also collect the 86- 90 ℃( 2.66 kPa) bit to gain 2- methoxy-4-chloro-5-fluoropyrimidine. Add the chlorinated product from the former step and anhydrous methanol to the autoclave, pass ammonia to achromatism at room temperature, sluggishly increase the temperature to make the pressure reach 0.5 MPa, and stir to reply overnight. Cool to room temperature and discharge, and after treatment, gain 2- methoxy-4-amino-5-fluoropyrimidine, melting point 189- 191 ℃. Reply it with 30 hydrochloric acid at 100- 105 ℃ for 3h. Dematerialize the hydrolyzate under reduced pressure, dissolve the residue with water, add ammonia water to alkalize to pH 8.5, cool to below 5 ℃, sludge, gain crude flucytosine, and recrystallize with water to gain the finished product.

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