We supply Phenylephrine Hydrochloride API

We're a dependable supplier of Phenylephrine Hydrochloride API. This high- quality product is used in colorful medical applications, including as a sympathomimetic medicine to treat low blood pressure and as a decongestant for the nasal passages. Our product is produced through a rigorous manufacturing process to insure its chastity and effectiveness. We strive to give our guests with the stylish service and high- quality products at competitive prices. communicate us moment to learn further about our Phenylephrine Hydrochloride.

What's Phenylephrine HCL?

Phenylephrine HCL powder is a largely effective pharmaceutical emulsion used in the treatment of several medical conditions. It's It's a white or nearly white crystalline greasepaint. Melting point 140- 145 ℃. Easy to dissolve in water and ethanol, undoable in chloroform and ether. The melting point of left- handed free alkali is 169- 172 ℃. This active pharmaceutical component belongs to the class of picky nascence- 1 adrenergic agonists and is known for its important vasoconstrictive parcels.

it has a wide range of applications in the medical assiduity, including the treatment of sinus traffic, hay fever, and other nasal mislike symptoms. It's also used during surgery as a decongestant and as a original anesthetic for minor medical procedures. In addition, it is used to increase blood pressure in cases of shock and hypotension, and is used to treat priapism( a patient construction).

As a potent and dependable medicine component, it is largely valued by healthcare professionals for its effectiveness and versatility. The emulsion is manufactured to the loftiest norms of quality and chastity, icing that it meets all nonsupervisory conditions.

In summary, it is a important and effective pharmaceutical emulsion extensively used in the medical assiduity. Its capability to treat a variety of conditions, from nasal traffic to shock and hypotension, makes it an essential component for numerous specifics.

Basic Information

Product Name: Phenylephrine hydrochloride

CAS: 61-76-7

MF:C9H13NO2.ClH

MW:203.67

EINECS:200-517-3

MDL No.:MFCD00012605

Origin: China

Delivery Time: in stock

Structural formula:

Technical Specification

Package 1kg, 25kg or according to your demands

Storage conditions: Preserve in tightly closed container between 2～8℃

Transportation conditions Transportation at room temperature

Shelf Life 24 months

Application:

Phenylephrine HCL powder is generally used as an active pharmaceutical component( API) in the expression of colorful specifics. Some its common applications include:

Decongestants: it is extensively used in the product of oral and nasal decongestant products to palliate nasal traffic caused by disinclinations, sinusitis, or the common cold wave.

Ophthalmic results: It's used in the expression of ophthalmic results for dilating the pupil during eye examinations and surgeries. These results are used by ophthalmologists to more fantasize the structures inside the eye.

Hypotension Treatment: In certain cases, it is used in the development of specifics to treat low blood pressure, especially in clinical settings or during anesthesia.

Vasopressor Agents: It's also employed in the product of vasopressor specifics, which are used to raise blood pressure in exigency situations similar as septic shock or during surgical procedures.

Cardiac Arrest application: it can be incorporated into phrasings used for managing cardiac arrest to support blood pressure and rotation.

These applications emphasize the versatility of Phenylephrine hydrochloride as an API in the pharmaceutical assiduity, where it plays a pivotal part in the development of specifics for colorful medical conditions.

In vitro research

Phenylephrine Hydrochloride API causes rapid translocation of PKC epsilon (EC50=0.9 mm), but the proportion of loss from soluble fraction is smaller than that of ET-1. Phenylephrine induces a dose-dependent increase in the contractile force of high permeability cells in pCa7, which is reversible after the addition of phentolamine. it can also protect myocardial cells from hypoxia and serum deprivation. it prevents downregulation of mRNA/proteins in Bcl-2 and Bcl-X and induces hypertrophic growth. The protection mediated by Phenylephrine is inhibited by the phosphatidylinositol 3-kinase (PI3 kinase) inhibitor wortmannin and mimicked by the cystatin 9 peptide inhibitor LEHD-FMK. it stimulates the hydrolysis of phosphoinositol (PI), cell growth, and the expression of several genes related to cardiac hypertrophy, such as atrial natriuretic factor (ANF). Phenylephrine (1 μ M) significantly enhances HGF induced DNA synthesis and cell proliferation in liver cells. Phenylephrine (1mM) reversibly increased I (Ca, L) by 51.3%; The peak I (Ca, L) of N=40 and the activation voltage of -10 mV transfer were observed. it also increased the release of local SR calcium ions through IP3 dependent signaling. Phenylephrin induces the release of NOi, requiring stimulation of PI-3K/Akt and IP3- dependent calcium ion signals. it induces the release of NOi, which is inhibited by 1mM prazocin, 10mML NIO, 10mMW-7, 10mML Y294002,2mMH-89, 10mM ryanodine, 5mM thapsigargin, and 2mM2 APfor10mM xestosporginC.

Production methods

M-hydroxyethyl ketone undergoes benzoylation, bromination, amination, hydrolysis, and catalytic hydrogenation to obtain m-hydroxy - α - methylaminomethylbenzyl alcohol (racemate), which is then separated with d-tartaric acid to obtain a levorotatory free base. Suspend free alkali in anhydrous ethanol, add hydrogen chloride ethanol solution to pH=4, heat to dissolve, add activated carbon for decolorization and filtration, add anhydrous ether to the filtrate, freeze and precipitate crystals. Shake filter, wash with a small amount of acetone for crystallization, dry to obtain phenylepinephrine hydrochloride.

Packing & Shipping

Packing: 1kg/foil bag;5kg/carton;25kg/fiber drum;or packing as your request.

Customization: Customized logo; Customized packaging; Graphic customization

Shipping:

Lead time: Within 3 workdays after receiving payment.

Payment Term

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In summary, as a professional Phenylephrine HCL powdermanufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make it stand out in the market competition and win more customer trust and support. if you need Phenylephrine Hydrochloride, pls feel free to contact us any time. we will reply to you ASAP.

our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937