Tigecycline API
Package: 100g;1kg
Origin: China
Supply Ability: 100kg per month
Sample Available: Yes
Shelf Life: Two years
Payment: T/T, LC or DA
Certifications: ISO9001, ISO22000, HACCP, HALAL, KOSHER
Third Party Test: available
Plant Audition: available
Can’t sell to individuals
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Product Introduction
What is Tigecycline API?
Tigecycline API is a broad-diapason antibiotic and an outgrowth of Tetracycline antibiotics. It's a white to out-white crystalline powder. Its chemical name is( 4S, 4aS, 5aR, 12aS)- 9-( 2-( tert- butylamino) acetamido) -4,7-bis( dimethylamino)-- octahydro- 3H-- pentahydroxy -1,11-dioxo-2-naphthacenecarboxamide. Its chemical formula is C29H39N5O8, and its molecular weight is 585.65 g/ spook, and its CAS is 220620-09-7. It's slightly answerable in water. It exhibits good solubility in common organic detergents similar as methanol, ethanol, and dimethyl sulfoxide.
Tigecycline antibiotic is a Semisynthesis antibiotic, and its structure is grounded on a tetracycline patch. It has broad- diapason antibacterial exertion and can produce antibacterial goods against colorful Gram-positive and negative bacteria. Its pharmacological parcels make it precious in the treatment of complicated skin and soft towel infections, complicated intra-abdominal infections, and other severe infections. It exerts its antibacterial action by inhibiting bacterial protein conflation. Compared to traditional tetracycline antibiotics, It has a wider range of antibacterial exertion and remains effective against some bacterial strains that have developed resistance to other antibiotics.
Its development timeline is as follows:
Early 1990s: It was synthesized and developed by scientists at Wyeth( now Pfizer). It was attained through structural variations of tetracycline antibiotics.
2005: It entered blessing from the U.S. Food and Drug Administration( FDA) and became the first broad- diapason antibiotic deduced from tetracycline to be retailed.
2006: It attained blessing for marketing in Europe and gradationally gained enrollment and blessing in other countries and regions for the treatment of colorful contagious cases.
2013: Pfizer blazoned the termination of Tigecycline's powder for injection but continued to produce and vend its expression in tablet form.
To date, It has been extensively used in clinical practice as a first-line or indispensable medicine for the treatment of complicated skin and soft towel infections, complicated intra-abdominal infections, and other severe infections. Despite its unique advantages in antimicrobial diapason, resistance, and efficacity, it still requires careful evaluation and monitoring in clinical use to ensure its rational use and minimize the threat of antibiotic resistance.
Basic Information
Product name | Tigecycline |
Chemical name | (4S,4aS,5aR,12aS)-9-(2-(tert-butylamino)acetamido)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3H-3a,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide |
CAS | 220620-09-7 |
MF | C29H39N5O8 |
MW | 585.65 |
EINECS | 685-736-6 |
MDL No. | MFCD00935753 |
Purity | 99% |
Stability | Stable |
Application | Medicine grade & Research grade. |
Packing | As per your request |
Storage | Room temp. |
Structural formula |
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Quality standard
Test | Specification | Result | |||
Description | Orange crystalline powder | Complies | |||
Solubility | Soluble in DMF, slightly soluble in water and dissolved in 0.1mol/L hydrochloric acid | Complies | |||
Specific rotation | -225o~-245o | Complies | |||
absorption coefficient | 412~438 at 246nm | Complies | |||
Ultraviolet absorption | Max at 246nm and 350nm Min at 315nm | Complies | |||
PH | 7.5~8.5 | Complies | |||
Related substances | Individual Impurities | ≤0.2% | 0.15% | ||
Total Impurities | ≤0.5% | 0.4% | |||
Residual Solvent(GC) | Isopropyl ether | ≤0.5% | 0.4% | ||
Methnol | ≤0.3% | 0.2% | |||
ethanol | ≤0.5% | 0.4% | |||
toluene | ≤0.089% | 0.06% | |||
dichloromethane | ≤0.06% | 0.05% | |||
Isopropanol | ≤0.5% | 0.4% | |||
acetone | ≤0.5% | 0.3 | |||
Loss on Drying | ≤2. 0% | 1.5% | |||
heavy metal | ≤10ppm | Complies | |||
Bacterial endotoxin | ≤0.5EU/mg | Complies | |||
Assay (via HPLC) | Between 98.5% and 101.5% | 99% |
Stability
Tigecycline Stability can be summarized as follows:
Photosensitivity: It's sensitive to light and can degrade when exposed to light, especially ultraviolet( UV) light. It's recommended to avoid exposing it to bright light and store it in opaque holders to cover the medicine from light exposure.
Moisture and humidity: It can absorb humidity in high moisture conditions, which may lead to declination or corruption. thus, it should be stored in sealed holders and kept down from moisture and humidity. Before use, insure dry hands to help fresh humidity from entering the powder
Temperature: its stability is closely related to temperature. In general, it should be stored at room temperature (approximately 15-30 degrees Celsius). Avoid excessively high or low temperatures.
Packaging: Proper packaging helps protect it from external factors. Common packaging methods include sealed aluminum foil bags or moisture-resistant bottles to provide good protection and isolation.
In summary, to ensure its stability, it should be stored in a light-protected, dry, and temperature-appropriate environment, while following the drug's expiration date.
Storage
Its storage conditions are crucial to maintain the quality and stability of the medication. Here are some recommendations for storing:
Temperature: It should be stored in a controlled temperature environment. Generally, room temperature (around 15-30 degrees Celsius) is the most suitable range. Avoid excessively high or low temperatures to prevent heat or freezing damage to the medication.
Light: It is photosensitive, so it should avoid exposure to bright light, especially ultraviolet light. Choose opaque containers or packaging and keep the storage area dimly lit to reduce light exposure.
Humidity: Tigecycline API can absorb humidity in high-moisture surroundings, leading to declination or loss of quality. thus, store it in a dry place and avoid humidity exposure.
Packaging: Opt for sealed and humidity-resistant packaging accouterments similar as aluminum antipode bags or humidity-resistant bottles to give good protection and insulation. ensure the packaging is complete and duly sealed to help exposure to the external terrain.
Expiration date: Carefully check and follow the medication's expiration date. Do not use expired it, as its stability and effectiveness may be compromised.
In summary, it is necessary to avoid moisture, light, and high temperatures, use appropriate storage containers, and keep it at room temperature while ensuring a proper seal.
Packing & Shipping
Packing: 1kg/foil bag;5kg/carton;25kg/fiber drum; or packing as your request.
Customization: Customized logo; Customized packaging; Graphic customization
Shipping:
Item | Quantity | ETA time | Shipping Method |
By Courier | ≤50kg | 7-15days | Fedex, DHL,UPS,TNT,EMS ect. Fast and convenient |
By Air | 50kg~200kg | 3-5days | Fast and cheap |
By Sea | Large quantity | 20-35days | Cheapest way |
Lead time: Within 3 workdays after receiving payment.
Payment Term
Why Choose Xi'an Yihui?
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Our Advantage
Rich experience: we have 13 Years of professional experience;
Customers all over the world: sell to more than 100 countries;
Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.
Price advance: low MOQ with competitive price;
Quality certification: ISO; Halal; Kosher certified
After-sales service: Professional team 7*24 hours customer service.
In conclusion
In summary, Xi'an Yihui company as a professional Tigecycline API manufacturer, has strong technical strength and advanced production equipment and is committed to providing customers with high-quality, efficient and reliable drug raw materials. if you need it, pls feel free to contact us any time. we will reply you ASAP.
Our contact information:
E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937
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