Tiotropium Bromide Powder

CAS:136310-93-5
MF:C19H22BrNO4S2
MW:472.42
Package: 1g; 10g;100g;1kg
Origin: China
Sample Available: Yes
Delivery Time: Delivery within 3 days from warehouse after payment or order
Shelf Life: Two years
Payment: T/T, LC or DA
Certifications: ISO9001, ISO22000, HACCP, HALAL, KOSHER
Third Party Test: available
Plant Audition: available
Can't sell to individuals
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Product Introduction

What is Tiotropium Bromide Powder?

Tiotropium bromide powder is an active pharmaceutical component. it's used for the treatment of habitual obstructive pulmonary complaint and bronchial asthma. It's a white to out-white crystalline powder. By blocking these receptors, it can reduce smooth muscle compression, drop airway concealment, dilate the bronchi, palliate pain and seditious responses, and ameliorate respiratory function. Its chemical name is( 1alpha, 2beta, 4beta, 7beta)- 7-(( hydroxydi-2-thienylacetyl) oxy) -9,9-dimethyl-3-oxa-9-azoniatricyclo(3.3.1.0) nonane bromide, and its molecular formula is C19H22NO4Br with a relative molecular mass of412.29 g/ spook. Its CAS number is 136310-93-5. It has low solubility in water but can dissolve in common organic detergents like ethanol and chloroform.

The timeline of its development is as follows:

1996- 2000 The exploration and development of tiotropium bromide began in the late 1990s. Boehringer Ingelheim and Pfizer banded on the exploration of this medicine.

2002 It entered blessing for marketing in Germany, Sweden, and the Netherlands for the treatment of COPD as a long- acting anticholinergic drug. Boehringer Ingelheim retailed it under the brand name Spiriva ®.

2004 The US FDA approved Spiriva ® for the treatment of COPD, making it as one of the most generally used specifics for COPD worldwide.

2005 Spiriva ® also entered blessing from the European Commission, further expanding its request.

2012 Spiriva ® Respimat ® inhaler( a new delivery device) gained blessing in Europe and the United States. This new inhalation device provides a more accessible way of administration.

2019 Boehringer Ingelheim blazoned a cooperation with Eli Lilly to launch a fixed- cure combination remedy of Spiriva ® Respimat ® and Olumiant ®( baricitinib) for the treatment of COPD in theU.S. request.

Since also, Tiotropium Bromide monohydrate has been extensively used encyclopedically and has experienced nonstop updates and advancements in its delivery styles to give better treatment efficacity and convenience.

Basic Information 

Product name

Tiotropium bromide

Other name

(1alpha,2beta,4beta,7beta)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0]nonane bromide

CAS

136310-93-5

MF

C19H22BrNO4S2

MW

472.42

EINECS

680-665-7

MDL No.

MFCD00867027

Purity

99%

Stability

Stable

Application

Medicine grade & Research grade.

Packing

As per your request

Storage

Room temp.

Structural formula

      136310-93-5.webp         

Quality standard 

Items

Specifications

Results

Appearance

White or almost white powder

White powder

Solubility

Sparingly soluble in methanol

Conforms

Identification

A: IR: the infra-red absorption spectrum is concordant with the spectrum obtained from tiotropium Bromide WS.


B: UV: the UV spectrum of 0.001% w/v solution in methanol in the range of 350nm to 200nm exhibits a maximam at about 238nm.

Conforms




Conforms

Specific optical rotation

-0.5°~+0.5°

0.015°

Residue on ignition

NMT 0.1% w/w

Conforms

Heavy metals

NMT20ppm

Conforms

Related substance

Single impurity(HPLC)

Total impurities


NMT 0.2%

NMT 1.0%


0.03%

0.48%

Assay

NLT 99.0%

99.52%

Conclusion: it complies as per the above specifications.

Storage

Tiotropium bromide powder storage conditions are as follows:

Temperature It should be stored at room temperature, around 25 °C. Avoid exposure to extremely high or low temperatures to help declination of the emulsion.

Light: Store it in a dark or low-light environment. Avoid direct sunlight or intense artificial light, as light exposure can cause degradation of the compound.

Moisture: It should be stored in a dry terrain. moisture can affect the stability of the emulsion, so it's important to prevent humidity from entering the storehouse vessel. You can use tightly sealed holders or maintain the original packaging's seal to help humidity contact.

Packaging: It's recommended to keep it in the original packaging to ensure optimal storehouse conditions and help external influences. However, be sure to reseal it tightly, If the original packaging is opened.

Air exposure: Avoid prolonged exposure to air, especially when not sealed. This helps prevent the compound from reacting with oxygen in the air and causing degradation.

Please note that the above are general storage recommendations. To ensure the best storage conditions and stability, it is advisable to refer to the specific storage instructions provided with the product and consult the manufacturer's guidelines.


Packing & Shipping

Packing: 1kg/foil bag;5kg/carton;25kg/fiber drum; or packing as your request.

Customization: Customized logo; Customized packaging; Graphic customization

Shipping:

Item

Quantity

ETA time

Shipping Method

By Courier

≤50kg

7-15days

Fedex, DHL,UPS,TNT,EMS ect.

Fast and convenient

By Air

50kg~200kg

3-5days

Fast and cheap

By Sea

Large quantity

20-35days

Cheapest way

Payment Term

 payment.webppayment.webp

Why Choose Xi'an Yihui?

Customer feedback

 Customer Comments.webp

Xi'an Yihui certificates

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Xi'an Yihui Factory & Warehouse

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Our Advantage

Rich experience: we have 13 Years of professional experience;

Customers all over the world: sell to more than 100 countries;

Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.

Price advance: low MOQ with competitive price;

Quality certification: ISO; Halal; Kosher certified

After-sales service: Professional team 7*24 hours customer service.

In conclusion

In summary, Xi'an Yihui company as a professional Tiotropium bromide powder produced manufacturer, has strong technical strength and advanced production equipment and is committed to providing customers with high-quality, efficient, and reliable drug raw materials. if you need it, pls feel free to contact us any time. we will reply you ASAP.

Our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937

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