We supply Beclomethasone dipropionate

Our company provides high-quality Beclomethasone dipropionate powder. This active ingredient is commonly used in the treatment of asthma and other respiratory disorders. With our product, you can be assured that you are receiving a pure and potent substance that meets strict quality control standards. Whether you are a pharmaceutical manufacturer or a research institution, our Beclomethasone dipropionate is the perfect solution for your needs. Contact us today to learn more about our products and how we can assist you in achieving your goals.

What's Beclomethasone dipropionate API?

Beclomethasone dipropionate API is a potent synthetic glucocorticoid steroid that is primarily used as an anti-inflammatory and immunosuppressive agent. It is commonly used to treat various breathing disorders, including asthma and chronic obstructive pulmonary disease (COPD), as it helps to reduce airway inflammation and increase air flow.

It is a white to almost white crystalline powder that is practically insoluble in water but is soluble in ethanol and chloroform. It is also stable under normal storage conditions, making it ideal for use in various formulations.

As an API, beclomethasone dipropionate is commonly used in the manufacture of various pharmaceutical products, including inhalers, nasal sprays, and topical creams. It is known for its efficacy and safety in treating respiratory disorders, and has been used for many years by healthcare professionals worldwide.

When used in inhalers or nasal sprays,it is delivered directly to the respiratory system, where it helps to reduce inflammation and improve breathing. When used in topical creams, it can help to relieve various skin conditions, including eczema and psoriasis.

Overall, it is a valuable pharmaceutical ingredient that plays a critical role in the treatment of various respiratory and skin disorders. Its efficacy and safety profile make it a preferred choice among healthcare professionals and patients alike.

Basic Information

Product Name: Beclomethasone dipropionate

CAS:5534-09-8

MF:C28H37ClO7

MW:521.04

EINECS:226-886-0

MDL No.:MFCD00135613

Density: 1.26g/cm3

Melting point: 210 º C

Boiling point: 630.5 ℃

Flash point: 335.1 º C

Refractive index: 1.564

Structural formula:

Origin: China

Delivery Time: in stock

Technical Specification

Package: 1kg;5kg or according to your demands

Storage conditions: protected from light and moisture, sealed and dry

Transportation conditions: 2-8 ℃ transportation

Shelf Life:Powder: 2 years

Indication

Beclomethasone dipropionate is used to treat eczema, allergic dermatitis, neurodermatitis, lichen planus, discoid lupus erythematosus, palmoplantar pustulosis, contact dermatitis, localized psoriasis, pruritus, etc. Bichloromethasone dipropionate aerosol is used for chronic or allergic asthma and allergic rhinitis.

Application

It is a potent topical corticosteroid drug with anti-inflammatory, anti allergic, and anti itch effects. It can inhibit bronchial exudate, eliminate bronchial mucosal swelling, and relieve bronchial spasms

Corticosteroid drugs can be used to treat various inflammatory skin diseases.

Pharmacological characteristics

Beclomethasone dipropionate powder is a first generation artificially synthesized glucocorticoid and a precursor drug with low receptor affinity. 95% of beclomethasone dipropionate is rapidly hydrolyzed by enzymes into the active metabolite 17 mono beclomethasone dipropionate (17-BMP) in the lungs after inhalation, and ultimately hydrolyzed into inactive beclomethasone. BDP has low water solubility, resulting in slow dissolution in the mucus layer of bronchial mucosa, and its lung absorption process is limited by the rate of mucus dissolution. The absolute bioavailability of BDP and BMP orally is 13% and 26%, respectively, while the first pass elimination is around 70%.

Pharmacological effects and mechanisms of action

Beclomethasone dipropionate API is a potent glucocorticoid drug with stronger anti-inflammatory effects than dexamethasone, triamcinolone acetonide, fluoxetine, and triamcinolone. It has anti-inflammatory, anti allergic, anti itch, and anti mitotic effects. It has strong fat solubility and good penetration effect on the skin. It takes effect after 30 minutes of application to the affected area and lasts for a long time. External use mainly absorbs through hair follicles, sebaceous glands, and epidermis, with strong contraction of local microvessels and anti-inflammatory effects, without causing side effects caused by adrenal cortex dysfunction.

Pharmacokinetics

Aerosol: This product has strong lipophilicity and is easy to penetrate. About 25% of the inhaled amount reaches the lungs.

Cream: This product can be absorbed through the skin, especially at the site of skin damage, and can cause systemic reactions due to absorption when used on large areas of skin damage or long-term use of encapsulated dressings. This product has strong lipophilicity and is easy to penetrate. It takes 30 minutes to apply to the affected area and takes effect. The T1/2 of the ointment is about 3 hours. The effects of sodium retention and glycogen deposition are weak, and there are no male, female and protein assimilation hormone like effects, and there is no significant effect on body temperature and urine.

Security term

S36/37/39：Wear suitable protective clothing, gloves and eye/face protection.

S45：In case of accident or if you feel unwell, seek medical advice immediately (show the lable where possible).

S53：Avoid exposure - obtain special instructions before use.

Risk term

R60：May impair fertility.

R61：May cause harm to the unborn child.

Packing & Shipping

Packing：

1kg/foil bag;5kg/carton;25kg/fiber drum; or packing as your request.

Customization:

l Customized logo

l Customized packaging

l Graphic customization

Shipping：

By Courier; By Air or By Sea, according to your demands 

Payment Term

Why Choose Xi'an Yihui?

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Contact Yihui company

as a professional Beclomethasone dipropionate APImanufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make it stand out in the market competition and win more customer trust and support. if you need it, pls feel free to contact us any time. we will reply you asap.

our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937