We supply Bumetanide

We offer high- quality Bumetanide Active Pharmaceutical Ingredient( API) for pharmaceutical companies and exploration installations. Bumetanide API is a circle diuretic used to treat heart failure, edema, and other conditions that beget the body to retain redundant fluid. Our decoration- grade Bumetanide is produced in compliance with transnational norms and undergoes strict quality control measures to insure chastity and energy. We're committed to furnishing our guests with dependable and effective service, fast delivery, and competitive pricing. communicate us moment for further information on our Bumetanide and to request a quotation.

What is Bumetanide API?

Bumetanide is a largely effective pharmaceutical component used in the product of diuretic specifics. It belongs to the family of circle diuretics that work by blocking the reabsorption of sodium, chloride, and water in the feathers, performing in increased urine affair. This drug is generally specified to treat conditions similar as edema, congestive heart failure, habitual order complaint, and hypertension.

it is a potent remedial agent that has been clinically proven to be effective in managing fluid retention in cases with colorful health conditions. It's a safe and well- permitted drug when used according to the specified lozenge and under the supervision of a healthcare professional.

Its manufacturing adheres to strict quality control norms to insure its chastity and energy. It's formulated in compliance with transnational regulations and guidelines set forth by the World Health Organization, the European Medicines Agency, and the United States Food and Drug Administration.

Due to its high efficacity and safety profile, it is extensively used in the pharmaceutical assiduity to produce both ingrained and general diuretic specifics. It has come an essential component in the treatment of numerous healthcare conditions, and its fashionability continues to grow as further people profit from its remedial goods.

In conclusion, it is a precious medicinal component that helps to manage fluid retention and treat several health conditions effectively. Its quality, efficacity, and safety have been proven through expansive clinical trials, making it a trusted drug in the pharmaceutical assiduity.

Basic Information

Product Name: Bumetanide

CAS: 28395-03-1

MF:C17H20N2O5S

MW:364.42

EINECS:249-004-6

MDL No.:MFCD00078949

Density: 1.347g/cm3

Melting point: 230-231°C

Boiling point: 571.2ºC

Flash point: 299.3ºC

Refractive index: 1.612

Vapor pressure: 6.89E-14mmHg at 25°C

Structural formula:

Origin: China

Delivery Time: in stock

Technical Specification

Package: 100g;1kg or according to your demands

Storage conditions: protected from light and moisture, sealed and dry

Transportation conditions: 2-8 ℃ transportation

Shelf Life:Powder: 2 years

Application

Bumetanide API is a circle diuretic drug primarily used to treat conditions where redundant fluid retention occurs, similar as congestive heart failure and edema( fluid accumulation in the body). Then are some specific applications:

Congestive Heart Failure( CHF): it helps reduce fluid buildup in the body by adding the excretion of water and electrolytes through the feathers. This can relieve symptoms of CHF similar as briefness of breath and lump.

Edema: it is effective in treating edema associated with colorful conditions, including heart failure, liver complaint, and order complaint. It helps reduce swelling by promoting the elimination of redundant fluid.

Hypertension: In some cases, it may be used to help lower blood pressure, especially when hypertension is related to fluid retention.

Hyperkalemia: it can also be used to help lower high situations of potassium in the blood, particularly in cases with order dysfunction where potassium situations can come dangerously elevated.

Ascites: it is occasionally used in the application of ascites, which is fluid accumulation in the abdominal depression frequently seen in liver cirrhosis and certain cancers.

Neonatal Seizures: There's ongoing exploration and clinical use of bumetanide in treating neonatal seizures, particularly those associated with conditions like neonatal hypoxic- ischemic encephalopathy( HIE). its implicit neuroprotective goods are being delved in this environment.

It's important to note that it should be used under medical supervision due to its potent diuretic goods and implicit side goods, similar as electrolyte imbalances and dehumidification. Lozenge and administration should be precisely covered grounded on individual case requirements and response.

Pharmacological action

It is a outgrowth of m- aminobenzenesulfonamide and is a potent diuretic. The medium of diuretic action is related to the inhibition of the exertion of Na- K- ATPase. It substantially acts as a diuretic by inhibiting the active reabsorption of Cl- and the unresistant reabsorption of Na by the thick thrusting branch of the circle of Henle, thereby affecting the attention and dilution process of urine. It also acts on the proximal tubule and has a certain renal vasodilation effect. In the early stage of diuresis, Cl- excretion increases by 20 times and Na excretion increases by 13 times. When the medicine is continued, Cl- in urine is no longer further than Na. It has a weaker effect on inhibiting carbonic anhydrase than furosemide, so its potassium loss is also lighter than furosemide. 1 mg of bumetanide is roughly original to 40 mg of furosemide.

Pharmacokinetics

After oral administration, 95 is fleetly absorbed by the gastrointestinal tract, its bioavailability is 95, and its protein binding rate is 95. Diuretic effect occurs within 30 twinkles after administration. The blood attention reaches the peak in 1 to 2 hours, and the effect lasts for 4 to 6 hours. Diuretic effect occurs 5 twinkles after intravenous injection, reaches peak after 30 twinkles, and lasts for 2 to 3 hours. About 45 of the oral cure is excreted in its original form. The elimination half- life is 1 to1.5 hours, which is dragged in cases with renal failure.

Indications

It's used to treat edema caused by heart failure, liver complaint, and order complaint. It's substantially used for colorful refractory edema and acute pulmonary edema. It's particularly suitable for cases with acute and habitual renal failure.

Preparation

Add 0.1mol of 3-amino-4-phenoxy-5-sulfonamide benzoic acid to a reaction flask, then add 500ml of n-butanol, stir at room temperature, then add 10mmol of ferric chloride catalyst to the reaction flask, react for 6 hours, stop stirring after the reaction is completed, evaporate most of the n-butanol from the reaction solution, add 200ml of 2M sodium hydroxide solution and 100ml of ethanol, heat and reflux for 30 minutes, then add concentrated hydrochloric acid to adjust the pH to 8-8.2, cool, stand, and filter. After filtering, add water to the filter cake and heat to dissolve, add a small amount of activated carbon to decolorize, filter hot and cool to precipitate sodium salt, filter, add 300ml of water and heat to dissolve, then add concentrated hydrochloric acid to acidify to pH2-3, cool, filter, wash with water, and dry to obtain pure bumetanide with a yield of 64.5% and a purity of 99.6%.

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In summary, Xi'an Yihui company as a professional Bumetanide API manufacturer has strong technical strength and advanced production equipment and is committed to providing customers with high-quality, efficient and reliable drug raw materials. if you need it, pls feel free to contact us any time. we will reply you ASAP.

Our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937