We supply Griseofulvin API

We offer Griseofulvin API as a high-quality pharmaceutical ingredient for research and development purposes. it is a potent antifungal drug used to treat a variety of dermatophytosis infections, including ringworm and athlete's foot. Our Griseofulvin is manufactured with stringent quality control measures to ensure purity, potency, and consistency. We maintain a stable supply chain to meet the demands of research institutions, pharmaceutical companies, and other commercial enterprises. Contact us to learn more about our Griseofulvin powder and other pharmaceutical products.

What's Griseofulvin ?

Griseofulvin is a non polyene antifungal antibiotic that strongly inhibits fungal cell mitosis, interferes with fungal DNA synthesis, and binds to microtubule proteins to prevent fungal cell division. Since 1958, it has been widely used in medical clinical practice and has been widely used to treat fungal infections in the skin and stratum corneum. It has a strong inhibitory effect on red tinea, trichophyton, and trichophyton. It is not only a commonly used antibiotic in clinical treatment of fungal infections in the skin and stratum corneum, but also in agriculture, it is used for the prevention and control of fungal diseases. A type of candidiasis in apples can cause infection during flower pollination, and it has special therapeutic effects on this.

Basic Information

Product Name: (+)-Griseofulvin

CAS: 126-07-8

MF:C17H17ClO6

MW:352.77

EINECS:204-767-4

MDL No.:MFCD00082343

Structural formula:

Origin: China

Application: Antibiotic;Antifungal

Delivery Time: in stock

Technical Specification

Package: 1kg; 5kg;25kg

Storage: Preserve in tight,light-resistant containers in a cool place

Shelf Life: 24 months

Application:

This product has inhibitory effects on various dermatophytes, including dermatophytes, dermatophytes, and microsporidia. It is ineffective against tinea versicolor, white yeast, and bacteria. This product has antibacterial effects and is effective against growing fungi. This product is used for tinea scalp, onychomycosis, tinea pedis, tinea pedis, and tinea corporis caused by sensitive fungi.

It has an inhibitory effect on various dermatophytes and is effective against thriving fungi. Suitable for the treatment of various ringworm diseases, including tinea scalp, tinea beard, tinea corporis, tinea cruris, tinea pedis, and onychomycosis.

Physical and chemical properties

Griseofulvin API is a colorless crystal, neutral, insoluble in water, and has strong internal absorption. It is stable to environmental factors both inside and outside the plant and at pH 3.0-8.8, and can prevent and control various plant fungal diseases. The main strains produced in our country are Penicillium niger and Penicillium urticae. On the culture medium, the fur of Penicillium niger appears as original hairs, and when newly cultured, it is pure gray. When it ages, it turns dark gray, and the back is deep orange red to orange brown. The fungal coating of Urticaceae Penicillium is light yellow green to pure bright gray, thick and dense, and the back is light turbid yellow to brownish. Their aerial hyphae are very broom like.

Griseofulvin powder is suitable for the treatment of various types of tinea, including tinea scalp, tinea beard, tinea corporis, tinea cruris, tinea pedis, and onychomycosis. This product is not suitable for mild or limited superficial fungal infections, as well as for those who have already been treated with local antifungal drugs and are already effective. it is ineffective against infections such as Candida, Histoplasma, Actinobacteria, Sporothrix, Blastomyces, Conidia, Nocardia, and Cryptococcus, as well as against tinea versicolor.

Pharmacological action

In medicine, this product mainly has good antibacterial effects on superficial fungi such as Trichophyton, Microsporium, and Epidermis. It has no antibacterial effect on Candida, Cryptococcus, Histoplasma, Sporothrix, Blastomyces, and Conidia. This drug system inhibits the growth of fungi by interfering with their nucleic acid synthesis.

In agriculture, this product has inhibitory effects on Ascomycetes, Basidiomycetes, Pseudomonas aeruginosa, and certain algae, but only has no effect on egg fungi without chitin in in the cell wall. After spraying crops such as melons, they can enter the branches, leaves, fruits, and other parts of the plant through internal absorption conduction, absorption of aqueous solutions by the root system, and transpiration, to prevent and control fungal diseases. According to Briau et al. (1946), even if its concentration is as low as 10mg/L or even 1mg/L, it can make the hyphae of Bctrytisalll and other fungi thick, deformed, spiral shaped, and show a large number of abnormal branching; The development of germinated conidia is hindered, losing their apical advantage; Thus, it has internal absorption therapeutic activity against various plant diseases, especially against powdery mildew and gray mold, and its antibacterial activity is more prominent than its bactericidal activity.

Pharmacokinetics

The oral absorption of this product varies depending on the preparation. The microparticle form of this drug can be absorbed by 25% to 70%, while the ultra microparticle form is almost completely absorbed after oral administration. Eating fat can significantly increase absorption. The serum protein binding rate of this product is about 80%. After absorption, this product can deposit in the stratum corneum of the skin, hair, and nails, and combine with its keratin to prevent the continued invasion of sensitive skin fungi. Pathogenic fungi present in the superficial stratum corneum leave the body with the shedding of skin or hair, and are only distributed in small amounts to other body fluids and tissues. This product can also enter the fetal circulation and be secreted from breast milk. This product is metabolically inactivated in the liver, with the main metabolites being 6-methylgriseofulvin and its glucuronide. The half-life of blood elimination is 14-24 hours. Less than 1% of this product is excreted in its original form in urine, and approximately 16% to 36% is excreted in its original form in feces.

Indications

In medicine, this product is suitable for the treatment of various ringworm diseases, including tinea scalp, tinea beard, tinea corporis, tinea cruris, tinea pedis, and onychomycosis. The above-mentioned ringworm disease is caused by dark red ringworm fungus, broken ringworm fungus, beard ringworm fungus, interdigital ringworm fungus, as well as small spore bacteria such as Auduan, canine, gypsum like, and flocculent epidermal ringworm fungus. This product is not suitable for mild symptoms, limited superficial fungal infections, and those who have already been treated with local antifungal drugs. Griseofulvin is ineffective against infections such as Candida, Histoplasma, Actinobacteria, Sporothrix, Blastomyces, Conidia, Nocardia, and Cryptococcus, as well as against tinea versicolor.

In agriculture, this product was first introduced by Brian et al. (1951) to prevent and control plant diseases. According to existing research reports, it can prevent and control fungal diseases such as sweet melon (melon) stem blight, stem cracking, watermelon wilt, anthracnose, apple flower rot, apple cold rot, apple tree rot, cucumber downy mildew, strawberry gray mold, gourd suspension blight, rose powdery mildew, chrysanthemum powdery mildew, lettuce flower rot, tomato early blight, and tulip fire blight.

Adverse reactions

1. Nervous system headaches are more common, with about 10% of patients experiencing headaches. Initially severe, continuing medication can alleviate the symptoms. Other symptoms include drowsiness, fatigue, etc. Occasional occurrences include dizziness, ataxia, and peripheral neuritis.

2. A small number of patients with the digestive system may experience upper abdominal discomfort, nausea, or diarrhea, which is generally mild and tolerable by the patient.

3. About 3% of patients may experience allergic reactions, including rash, occasional vascular and neuroedema, persistent urticaria, and exfoliative dermatitis. A small number of patients may develop photosensitive dermatitis.

4. This product can occasionally cause a decrease in peripheral blood count and white blood cells, as well as liver toxicity and proteinuria.

Matters needing attention

1. Cross allergy: Due to the fact that griseofulvin is obtained from Penicillium, it is speculated that the drug may have a cross allergy with penicillin or penicillamine. However, this situation has not been clinically confirmed, but patients with penicillin allergy still need to be cautious and closely observe when using this product.

2. It has a tumorigenic effect in animal experiments.

3. This product can occasionally cause liver toxicity. Patients with pre-existing liver disease or liver function damage need to weigh the pros and cons before deciding whether to take the medication.

4. This product can induce porphyria and lupus erythematosus. If lupus erythematosus patients have indications to use this drug, they must weigh the pros and cons before making a decision.

5. Regular testing of peripheral blood, liver function, blood urea nitrogen, creatinine, and urine routine is required during treatment.

6. This product can be taken together with or after meals, with a high-fat meal being the best option as it can reduce gastrointestinal reactions and increase drug absorption.

To prevent recurrence, treatment should continue until clinical symptoms disappear and laboratory tests confirm that the pathogen has been completely eradicated. The general treatment period is 8-10 weeks for tinea scalp; Tinea corporis for 2-4 weeks; Tinea pedis for 4-8 weeks; Nail ringworm for at least 4 months; Tinea toenail for at least 6 months; But the recurrence rate of toenail tinea is still high.

8. It is usually necessary to administer appropriate local medication simultaneously, which is particularly important for tinea pedis.

Male patients should take contraceptive measures during and at least 6 months after treatment.

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In summary, as a professional Griseofulvin API manufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make it stand out in the market competition and win more customer trust and support. if you need Griseofulvin powder, pls feel free to contact us any time. we will reply you asap.

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E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
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