We supply Fondaparinux sodium API

We specialize in furnishing high- quality Fondaparinux sodium powder, a drug used to help and treat blood clots. Our product is sourced from trusted manufacturers and undergoes strict quality control processes to insure its chastity and effectiveness. It's a dependable anticoagulant and is extensively used in the medical assiduity for its efficacity in precluding deep tone thrombosis and pulmonary embolism. Whether you're a pharmaceutical company, sanitarium or clinical laboratory, we can give you with a dependable force of Fondaparinux sodium to meet your requirements. communicate us moment to learn further about our product and services.

What's Fondaparinux sodium?

Fondaparinux sodium powder is a new type of antithrombotic medicine approved by the FDA for the treatment and forestallment of colorful arterial and venous thrombosis, following heparin and low molecular weight heparin. Sulfonamide sodium is an instinctively synthesized specific actuated Xa factor asset, which works by widely binding to factor A, enhancing the negativing effect of AITn on actuated Xa factors by about 30 times, thereby dismembering the coagulation waterfall response and inhibiting thrombin product and thrombus progression. Sulfonamide sodium doesn't have a direct effect on thrombin, but can effectively inhibit thrombin product by inhibiting clotting factor Xa. It's estimated that every 1 patch of Xa factor inhibition can help 50 motes of thrombin product.

Basic Information

Product Name: Fondaparinux sodium

CAS:114870-03-0

MF:C31H43N3O49S8.10Na

MW:1728.08

EINECS:686-283-7

MDL No.:MFCD06794972

Purity: 99%+

Origin: China

Application: Anticoagulant

Delivery Time: stock

Structural formula:

Melting point:>209 ° C (dec.)

Specific rotation: D23+48 ° (c=0.61 in water)

Solubility: soluble in water

Technical Specification:

Package: 10g; 50g; 100g

Storage conditions: Keep in dark place, Inert atmosphere,2-8°C

Safety Information

Warning word: Warning

Hazard Statement: H332 Inhalation Harmful

Prevention instructions:

Preventive measures:

——P261 Avoid breathing dust/smoke/gas/smoke/vapor/spray.

——P271 can only be used outdoors or with good ventilation.

Accident response:

——P304+P340 If accidentally inhaled: Transfer the person to a place with fresh air and maintain a comfortable breathing position.

——P312 If feeling unwell, call the detoxification center/doctor

Health hazards: Harmful by inhalation.

Synthetic route

The preparation method includes the following steps:

1) In the presence of organic solvents and catalysts, monosaccharide E-3 is coupled with tetrasaccharide DCBA-2 to obtain pentasaccharide EDCBA-1.

2) Under the presence of organic solvents and inorganic bases, pentasaccharide EDCBA-1 is hydrolyzed to obtain pentasaccharide EDCBA-2; The organic solvent described is a mixture of one or more of dichloromethane, methanol, ethanol, and tetrahydrofuran; The inorganic base is one or a mixture of sodium hydroxide and potassium hydroxide; The reaction temperature is 0-50 ℃.

3) Sulfonation of pentasaccharide EDCBA-2 with sulfur trioxide trimethylamine, catalytic hydrogenation, and sulfonation with sulfur trioxide pyridine to obtain fondaparinux sodium.

Pharmacological action

Fondaparinux sodium powder is an artificially synthesized and selective inhibitor of activating factor X. Its antithrombotic activity is the result of selective inhibition of factor Xa mediated by antithrombin III (ATIII). By selectively binding to ATIII, it enhances (approximately 300 times) the original neutralizing activity of ATIII towards factor Xa. The neutralizing effect on factor Xa disrupts the coagulation cascade reaction and inhibits the formation of thrombin and thrombus enlargement. It cannot inactivate thrombin (activating factor II) and has no effect on platelets. At a dose of 2.5mg, sulfamethoxazole does not affect routine coagulation tests such as activated partial thromboplastin time (aPTT), activated coagulation time (ACT), or plasma prothrombin time (PT)/international standardized ratio (INR), nor does it affect bleeding time or fibrinolytic activity. However, there have also been rare spontaneous reports of a 2.5mg dose increase in aPTT. It does not cross react with plasma from patients with heparin induced thrombocytopenia.

What is the application of Fondaparinux sodium

Fondaparinux sodium is used in patients undergoing major orthopedic surgeries in the lower limbs, such as hip fractures, major knee surgeries, or hip replacements, to prevent the occurrence of venous thromboembolism events. For the treatment of unstable angina or non ST segment elevation myocardial infarction patients undergoing emergency (<120 minutes Chemicalbook) invasive treatment (PCI) without indication. Used for the treatment of ST segment elevation myocardial infarction patients who use thrombolysis or do not initially receive other forms of reperfusion therapy.

Reference materials

Ma Ying, Zhao Baolian, Wang Xuanqi, etc A comparative study on the efficacy and safety of sulfamethoxazole sodium injection and low molecular weight heparin calcium injection during percutaneous coronary intervention in patients with non ST segment elevation acute coronary syndrome. CNKI, 2017

Tang Yongqun, Huang Xiwei, Hu Zheng A detection method for free sulfate ions in sulfamethoxazole sodium injection

Tang Yongqun, Huang Xiwei, Hu Zheng A production method of sulfamethoxazole sodium injection

Zhang Xiaoyan, Wang Lijuan A clinical study on the combination of Danhong injection and sulfamethoxazole sodium in the treatment of pulmonary embolism. CNKI, 2018

Haisike: Application for Production of Sodium Sulfonate Injection. Stock Market Dynamics Analysis, 2014

Contact information

In summary, as a supplier of Fondaparinux sodium powder , Xi'an Yihui has rich production experience and technical knowledge, high-quality products, flexible production capacity, and quality customer service, which can provide better support and service to customers.

if you need it, pls feel free to contact us any time. we will reply you asap.

Our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
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