2-Deoxy-D-glucose powder Supplier

Xi'an Yihui Company is a professional manufacturer of the best 2-Deoxy-D-glucose powder. We can generate 2DG with a 99.9% content. It can be utilized in food, medicine, health care items, or cosmetics and meets USP, BP, EP, CP standards. We can offer you products of the highest caliber at the most competitive rates. Your best option for a reputable pure 2DG supplier is Xi'an Yihui Company!

What Is 2-Deoxy-D-glucose powder?

2- Deoxy- D- glucose powder is a chemical substance， its chemical formula is C6H12O5 and its molecular weight is 164.16 g/ spook, its CAS NO. is 154-17-6. It's a six-carbon sugar analogous to glucose, but lacking a hydroxyl group at the alternate carbon snippet, hence called" deoxy" glucose. It's a white demitasse with low solubility in water. 2DG is a clinical metabolic disruptor that can inhibit cell glucose uptake and application, leading to a drop in ATP situations within cells.

This drug mainly acts on tumor cells and certain pathogens that rely on sugar as their main metabolic substrate. Using 2DG can effectively cause these cells to die or slow down their growth rate. Additionally, 2DG is used as a tool in neuroscience and metabolism research because it can simulate the state of metabolic exhaustion, revealing details of cellular metabolic pathways.

The discovery of 2- Deoxy- D- glucose can be traced back to the early 1950s. At that time, American scientists Haskell Smith and Morris Ficher discovered an emulsion called 2-deoxyglucose while studying cell glucose uptake mechanisms. Later, another scientist Takashi Otsuka discovered that 2-deoxy glucose could intrude with cell glucose metabolism and inhibit cell division during DNA conflation.

Later, scientists conducted further exploration on 2-DG powder and set up that it could inhibit the growth of certain cells and pathogens while having minimum goods on normal cells.

To ameliorate the efficacity of 2DG, scientists began designing and synthesizing analogous motes. In this process, they set up that 2DG was a more effective metabolic disruptor, able to more efficiently inhibit cell glucose uptake and application. Currently, 2DG has become an important experimental tool and clinical drug.

Basic Information

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Synthesis Process

The synthesis process of 2-deoxy-D-glucose powder involves two steps:

In the first step, glucose is subjected to Knoevenagel condensation by reacting with methyl vinyl ketone to yield an α,β-unsaturated carbonyl compound.

In the second step, tThe unsaturated compound is reduced to the target product 2-deoxy-D-glucose through hydrogenation reduction.

Here are the specific reaction processes:

First step reaction equation:

Glucose + Methyl vinyl ketone → α,β-unsaturated carbonyl compound

First step reaction mechanism:

Under alkaline conditions, glucose and methyl vinyl ketone act as nucleophilic reagents and undergo Knoevenagel condensation with the help of thioacetone or sodium hydroxide, yielding an α,β-unsaturated carbonyl compound.

Second step reaction equation:

α,β-unsaturated carbonyl compound + Hydrogen gas + Catalyst → 2-deoxy-D-glucose

Second step reaction mechanism:

In the presence of hydrogen gas and a catalyst, the- unsaturated carbonyl emulsion is hydrogenated to yield 2- deoxy- D- glucose. A essence catalyst similar as platinum or precaution is generally used for this hydrogenation response.

It should be noted that it's just one common style for synthesizing 2- deoxy- D- glucose. In fact, there are other different synthetic pathways, similar as chemical revision of uracil and microbial metabolism.

it is a very important compound that is widely used in medicine, biotechnology, and the food industry. Here are its some advantages:

It has no toxic side effects on the human body and has a selective killing effect on cancer cells;

It has anti-virus, antifungal, anti-diabetes, anti-obesity and other effects;

It can be absorbed and metabolized by the human body;

It can be used as a radiolabeled reagent or a DNA repair agent in biotechnology;

It can be used as a low-calorie sweetener in the food industry;

In short, it is a very useful compound with various applications.

What Is The Function Of 2 Deoxy Glucose?

2 deoxy glucose( 2DG) is a glucose analogue that lacks the hydroxyl group at the 2- position of the glucose ring. It's generally used in scientific exploration as a tool to probe glucose metabolism and its affiliated pathways. Here are some its functions:

1. Asset of glycolysis 2DG is taken up by cells through glucose transporters and phosphorylated by hexokinase to 2DG-6-phosphate, which can not be farther metabolized by glycolysis. thus, 2DG can competitively inhibit glucose uptake and glycolysis, which is the first step in energy metabolism.

2. Debaser of autophagy Autophagy is a cellular declination medium that helps to maintain cellular homeostasis by recovering damaged or unwanted proteins and organelles. 2DG induces autophagy by inhibiting the mammalian target of rapamycin( mTOR) pathway, leading to the activation of autophagy- related genes.

3. Radiosensitizer: Cancer cells have higher glucose uptake and glycolytic flux than normal cells, which is known as the Warburg effect. Therefore, 2DG can selectively sensitize cancer cells to radiotherapy by inhibiting glycolysis and enhancing cellular stress responses.

4. remedial eventuality for neurodegenerative conditions 2DG has been shown to ameliorate cognitive function and reduce neuropathology in beast models of Alzheimer's complaint and Parkinson's complaint. This might affect from the enhancement of glucose metabolism in the brain, reducing neuronal inflammation and oxidative stress.

5. Tool for metabolic labeling Due to its glucose- suchlike structure and capability to integrate into glycolysis, 2-deoxy-d-glucose API can be used as a metabolic marker to study the metabolic fate of glucose-deduced motes in cells and apkins.

In summary,2-deoxy d glucose has many important functions in scientific research, including as an inhibitor of glycolysis, an inducer of autophagy, a radiosensitizer, a therapeutic potential for neurodegenerative diseases, and a tool for metabolic labeling. Its applications have potential implications for both basic science and clinical medicine.

Packing & Shipping

Packing：1kg/foil bag;5kg/carton;25kg/fiber drum;or packing as your request.

Customization:

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Lead time: Within 3 workdays after receiving payment.

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Why Choose Xi'an Yihui?

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Our advantage

Rich experience: we have 13 Years of professional experience;

Customers all over the world: sell to more than 100 countries;

Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition, and functional food.

Price advance: low MOQ with competitive price;

Quality certification: ISO; Halal; Kosher certified

After-sales service: Professional team 7*24 hours customer service.

In conclusion

In summary, as a professional 2-Deoxy-D-glucose powder manufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make it stand out in the market competition and win more customer trust and support.

If you want to know more about 2-DG or are interested in purchasing it, you can contact us at any time. We will reply to you as soon as possible after we see the message.

our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937

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