We supply Ulipristal Acetate 

We're a dependable supplier of Ulipristal Acetate API. it is a hormone agonist/ antagonist that's primarily used as an exigency contraceptive lozenge. It works by inhibiting the goods of the hormone progesterone, which prevents gestation from being. Our Ulipristal Acetate is of high quality and chastity, icing safety and efficacity for medicinal operations. We give competitive prices, prompt delivery, and excellent client service. communicate us moment to learn further about our Ulipristal Acetate and how we can fulfill your medicinal needs.

What is Ulipristal Acetate

Ulipristal Acetate is a largely potent synthetic picky progesterone receptor modulator( SPRM) used in the development of a range of innovative women's health products. The API has displayed excellent clinical efficacity in the treatment of uterine fibroids and exigency contraception, pressing its versatility and broad remedial eventuality.

It exerts its remedial goods by widely binding to the progesterone receptor in the endometrium, leading to the inhibition of ovulation and the repression of progesterone- intermediated goods on endometrial towel. This results in the reduction of menstrual inflow and the forestallment of gestation, making it a largely effective contraceptive option.

In the treatment of uterine fibroids, it has been shown to effectively drop fibroid size and associated symptoms, similar as heavy menstrual bleeding and pelvic pain. This is achieved by converting apoptosis in fibroid cells and reducing vascularization of fibroid towel.

The pharmacokinetic parcels enable rapid-fire immersion and a long half- life, making it an ideal seeker for exigency contraception. When administered within 72 hours after vulnerable intercourse, it effectively prevents gestation with a success rate of over to 98, according to clinical studies.

Overall, it is a largely promising and protean API that holds great eventuality in the development of innovative women's health products. Its potent pharmacological parcels and proven clinical efficacity make it an seductive option for pharmaceutical companies aiming to expand their product range in this field.

Basic Information

Product Name: Ulipristal Acetate

CAS: 126784-99-4

MF:C30H37NO4

MW:475.62

EINECS:682-170-1

MDL No.:MFCD00899035

Melting point:183-185 ºC

Boiling point:640.1±55.0 °C(Predicted)

Structural formula:

Origin: China

Delivery Time: in stock

Technical Specification

Package: 10g;100g; 1kg or according to your demands

Storage: Preserve in tight,light-resistant containers in cool place

Shelf Life:Powder: 2 years

Pharmacological action

Ulipristal Acetate API is a progesterone agonist/ antagonist whose medium of action is to inhibit or delay ovulation; still, changes in the endometrium may also be one of the reasons for the efficacity. it is a picky progesterone receptor modulator that has negative and partial agonist goods on progesterone receptors. It binds to progesterone receptors in the mortal body to help progesterone from binding to progesterone receptors. The efficacity depends on the time of administration during the menstrual cycle. Administration during the middle of follicular hyperplasia inhibits follicle conformation and reduces estradiol attention. Administration during the peak of luteinizing hormone can delay follicle rupture by 5 to 9 days. Administration during the early luteal phase does n't significantly delay endometrial development, but can reduce endometrial consistence by 0.6 ± 2.2 mm( mean ± SD).

Pharmacokinetics

immersion Under fasting conditions, 20 women were given a single cure of ulipristal acetate, and the maximum tube attention of ulipristal acetate and the active metabolite( monodesmethyl- ulipristal acetate) reached 176 and 69 ng/ mL at 0.9 h and 1h, independently. When it was taken with a high- fat breakfast, the mean Cmax of ulipristal acetate and monodesmethyl- ulipristalacetate was 40 to 45 lower, the tmax was delayed( from a standard of 0.75 h to 3h), and the mean AUC0- ∞ was 20 to 25 advanced than when it was taken in the fasting state. These differences are n't anticipated to vitiate the efficacity or safety of ulipristal acetate, so it can be taken with or without food.

Distribution This product is largely bound to tube proteins(> 94), including high- viscosity lipoprotein, α-1-acid glycoprotein, and albumin.

Metabolism Ulipristalacetate is metabolized to mono- desmethyl and di- desmethyl metabolites. In vitro data indicate that the mono- desmethyl metabolite is pharmacologically active, substantially due to the agreement of CYP3A4.

Excretion The terminal half- life of ulipristalacetate in tube after a single cure of 30 mg of ulipristal acetate is estimated to be( 32.4 ± 6.3) h.

Market prospects

Exigency contraceptives, also known as exigency contraceptives, are exigency contraceptives for women of travail age to help unwanted gestation after vulnerable intercourse or contraceptive failure. At present, the most extensively used exigency contraceptive in clinical practice is levonorgestrel( 1evonorgestre1), which is taken with a cure of 1 tablet( 0.75 mg) at 12h intervals or 2 tablets( 1.5 mg) at a time. still, levonorgestrel is only approved for use as an exigency contraceptive within 72h( 3d) after vulnerable intercourse or contraceptive failure. Indeed so, the exigency contraceptive efficacity of levonorgestrel will significantly drop with the detention in drug, so it's recommended to start taking the drug within 12 hours after vulnerable intercourse or contraceptive failure.

In May 2009, the European Union approved a new exigency contraceptive, ulipristal acetate( EllaOne), which is n't only allowed to be taken within 120 hours( 5 days) after vulnerable intercourse or contraceptive failure, but also its exigency contraceptive efficacity wo n't drop with the detention in drug.

it is the first oral exigency contraceptive approved worldwide to be used within 120 hours after vulnerable intercourse or contraceptive failure, and has the implicit benefit of precluding further unplanned gravidity than levonorgestrel. As a new oral exigency contraceptive, it ca n't only be used within 120 hours after women have vulnerable intercourse, but also its exigency contraceptive efficacity wo n't drop with the detention in drug, and it's also veritably safe and well permitted. Compared with the most generally used exigency contraceptive levonorgestrel, it has a wider clinical connection and has the implicit to help further unplanned gravidity. Intellectual property status The original manufacturer has applied for patents for ulipristal acetate tablets, suggestions and operation in China, but has not yet been authorized, so there's no intellectual property hedge.

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Yihui takes pride in being a trusted Ulipristal Acetate API manufacturer and supplier. To acquire this groundbreaking product or discuss your specific requirements, contact us immediately at sales@yihuipharm.com. Rest assured, with Yihui, you're accessing a product of unparalleled quality, backed by certifications that underscore our commitment to excellence in the global market.