We supply Norepinephrine hydrochloride

Our company offers Norepinephrine hydrochloride , a potent drug used in the treatment of colorful cardiovascular conditions similar as low blood pressure and shock. This largely effective medicine workshop by stimulating the heart and blood vessels, therefore adding blood inflow and oxygen force to vital organs. it is manufactured using high- quality constituents and slice- edge technology, icing its chastity and safety. It's available in colorful forms and can be custom- acclimatized to meet your specific requirements. communicate us moment to learn further about how it can profit you or your cases.

What is Norepinephrine hydrochloride?

L-Norepinephrine Hydrochloride, scientific name 1--( 3,4- dihydroxyphenyl)-2-aminoethanol, is a substance formed by the junking of N- methyl from adrenaline. it isn't only a neurotransmitter, but substantially synthesized and buried by sympathetic postganglionic neurons and adrenergic whim-whams consummations in the brain. It's also a hormone released by the ultimate, synthesized and buried by the adrenal medulla, but in fairly small quantities. The norepinephrine in the circulating blood substantially comes from the adrenal medulla. it is an adrenaline receptor agonist that has the goods of constricting blood vessels and adding blood pressure. It's substantially used to deliver acute hypoxemia and shock caused by supplemental vasodilation. it has optic exertion, and the remedial effect of left- handed body is 27 times lesser than that of right- handed body. it is substantially synthesized instinctively.

it isn't only a neurotransmitter, substantially synthesized and buried by sympathetic postganglionic neurons and adrenergic whim-whams consummations in the brain, but also a hormone released by the ultimate. It's synthesized and buried by the adrenal medulla, but its content is fairly low. The norepinephrine in the circulating blood substantially comes from the adrenal medulla. It has a strong stimulating effect on nascence receptors, a weak effect on cardiac beta 1 receptors, and little effect on beta 2 receptors.

Basic Information

Product Name: Noradrenaline Hydrochloride

CAS: 329-56-6

MF:C8H11NO3.ClH

MW:205.64

EINECS:206-345-5

MDL No.:MFCD00064560

Structural formula:

Application: API

Origin: China

Delivery Time: in stock

Technical Specification

Package:100g; 1kg or according to your demands

Storage conditions: Preserve in tightly closed container between2-8°C

Shelf Life: 24 months

Application

Norepinephrine hydrochloride, also known as Noradrenaline hcl, has several important applications in drug and exploration due to its physiological goods. Then are some crucial applications

Treatment of Hypotension: it is generally used in clinical settings to treat severe hypotension( low blood pressure), particularly in cases of shock(e.g., septic shock, cardiogenic shock). Its vasoconstrictive goods help increase blood pressure and ameliorate perfusion to vital organs.

Cardiac Arrest: it can be used during cardiac arrest to support rotation and maintain blood pressure until normal heart function is restored.

Anesthesia:  In anesthesia, it is used to offset the hypotensive goods of anesthetics and maintain stable blood pressure during surgery.

Emergency Medicine:  It's employed in exigency drug to manage acute occurrences of low blood pressure that aren't responsive to other treatments.

Research: it is extensively used in neuroscience and pharmacology exploration to study its part as a neurotransmitter, its goods on colorful physiological systems, and its relations with adrenergic receptors.

individual Testing : In some cases, it is used as a individual agent to assess cardiovascular function and responsiveness to adrenergic stimulation.

Shock States:  Beyond clinical settings, noradrenaline's capability to increase systemic vascular resistance makes it useful in managing shock countries of colorful origins, including septic shock, neurogenic shock, and anaphylactic shock.

It's important to note that it is a potent drug that requires careful dosing and monitoring due to its eventuality to beget adverse goods similar as hypertension, towel necrosis if extravasation occurs during administration, and arrhythmias. Its use should be guided by medical professionals endured in its administration and application of associated pitfalls.

Biological activity

L-Norepinephrine Hydrochloride is a neurotransmitter and hormone that plays a pivotal part in the sympathetic nervous system's response to stress. Its natural conditioning include

Neurotransmission: it acts as a neurotransmitter in the central nervous system( CNS) and supplemental nervous system( PNS), where it modulates colorful physiological functions similar as attention, thrill, and mood.

Peripheral goods:  In the PNS, noradrenaline acts on adrenergic receptors located on smooth muscle cells of blood vessels, causing vasoconstriction. This action helps regulate blood pressure and blood inflow.

Cardiovascular goods : it is involved in regulating heart rate and contractility through its conduct on adrenergic receptors in cardiac towel. It can increase cardiac affair and blood pressure in response to stress or peril.

Metabolic goods: it can impact metabolism by promoting lipolysis( breakdown of fats) and glycogenolysis( breakdown of glycogen into glucose), furnishing energy substrates during stress responses.

Respiratory goods: It can stimulate respiratory centers in the brainstem, adding respiratory rate and perfecting oxygen delivery during fight- or- flight responses.

Cognitive Function: it is involved in cognitive processes similar as attention, literacy, and memory connection, primarily through its conduct in the CNS.

Mood Regulation:  Dysregulation of noradrenaline signaling has been intertwined in mood diseases similar as depression and anxiety. specifics targeting noradrenaline pathways are used in the treatment of these conditions.

In pharmacology, it is also used clinically to treat conditions similar as hypotension( low blood pressure) and septic shock, where its vasoconstrictive parcels can help stabilize blood pressure and ameliorate perfusion to vital organs. The natural conditioning of noradrenaline make it a critical middleman of the body's response to stress and conservation of physiological homeostasis.

Pharmacological action

This product is a strong nascence receptor agonist, with weak goods on β 1 receptors and little effect on β 2 receptors. The activation of nascence receptors can beget vasoconstriction in small highways and modes. The degree of vasoconstriction is related to the nascence receptors on the blood vessels, with skin and mucosal vasoconstriction being the most significant, followed by renal vessels. The effect on coronary highways isn't significant, which may be related to the increase in cardiac metabolites and the expansion of coronary highways, which counteracts the effect of this product. By stimulating the β 1 receptor, myocardial compression is strengthened and heart rate increases, but the intensity of action is important weaker than that of adrenaline. The range of vasoconstriction caused by nascence receptor activation is veritably wide, with skin, mucosal blood vessels, and glomeruli being the most egregious, followed by brain, liver, mesentery, cadaverous muscle, etc. After cardiac excitation, the metabolic product of myocardial adenosine increases, which can promote coronary roadway dilation. The cardiac instantiations of nascence receptor activation substantially include increased myocardial contractility, increased heart rate, and increased cardiac affair; In general, due to high blood pressure, it can beget reflexive excitation of the vagus whim-whams, leading to a retardation in heart rate and a drop in cardiac compression rate. The use of atropine can help this retardation in heart rate. Due to strong vasoconstriction, supplemental resistance increases, performing in unchanged or dropped cardiac affair. High boluses can also beget arrhythmia, but it's fairly rare. Blood pressure The increase in supplemental blood vessel compression and myocardial compression force leads to an increase in blood force, performing in an increase in both systolic and diastolic blood pressure, and a slight increase in palpitation pressure. Other It has a weaker effect on other smooth muscles, but can increase the frequence of uterine condensation in pregnant women, and has a weaker impact on body metabolism. Only at high boluses can blood sugar increase. Due to the difficulty in crossing the blood- brain hedge, there's nearly no central effect. inordinate or prolonged use can beget condensation of capillaries, leakage of body fluids, and drop in blood solubility.

Security information

Packaging level: II

Hazard category: 6.1

Customs code: 2922509090

Dangerous goods transportation code: UN 2811 6.1/PG 2

WGK Germany：3

Hazard category code: R26/27/28

Safety instructions: S28-S36/37-S45

RTECS number: DN5950000

Dangerous goods label: T+

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Yihui takes pride in being a trusted Norepinephrine hydrochloride manufacturer and supplier. To acquire this groundbreaking product or discuss your specific requirements, contact us immediately at sales@yihuipharm.com. Rest assured, with Yihui, you're accessing a product of unparalleled quality, backed by certifications that underscore our commitment to excellence in the global market.