We supply Famotidine API

Our company provides Famotidine API, which is a potent H2 receptor antagonist that reduces the stashing of gastric acid and is used in the treatment of acid- related gastrointestinal conditions similar as gastroesophageal influx complaint( GERD), peptic ulcer complaint, and Zollinger- Ellison pattern. Our Famotidine boasts high chastity and excellent quality, and it's produced and tested in strict agreement with transnational norms. It's extensively honored in the pharmaceutical assiduity for its efficacity, safety, and trustability. With our strong exploration and product capabilities, we're committed to furnishing our guests with dependable and high- quality Famotidine Powder.

What's Famotidine API ?

it is an active pharmaceutical component used in the expression of drugs to treat gastrointestinal diseases. It's a histamine H2- receptor antagonist, which means it works by blocking the action of histamine in the stomach, thereby reducing acid stashing and furnishing relief from conditions similar as gastroesophageal influx complaint( GERD), peptic ulcers, and zollinger- ellison pattern.

it is a white to pale unheroic crystalline greasepaint that's answerable in water and alcohol. It has a molecular weight of337.43 and its chemical name is N-( aminosulfonyl)- 3-((( 2-(( diaminomethylene) amino)-4-thiazolyl) methyl) thio) propanimidamide.

As an API, it is largely effective and extensively used in the pharmaceutical assiduity for the product of colorful untoward and tradition specifics. It can be used alone or in combination with other medicines, depending on the inflexibility and type of condition being treated.

At present, it is extensively used in the product of untoward antacids and tradition specifics similar as Pepcid and Fluxid. It's also used in veterinary drug to treat gastric ulcers in creatures. With its effectiveness and utility in the operation of gastrointestinal problems,its demand is anticipated to continue to increase in the coming times.

Overall, it is a dependable and effective component used in the product of drugs to treat a variety of gastrointestinal diseases. It offers a well- permitted and effective treatment option for cases suffering from GERD, peptic ulcers, and other affiliated conditions.

Basic Information

Product Name: Famotidine

CAS:76824-35-6

MF:C8H15N7O2S3

MW:337.45

EINECS:616-396-9

MDL No.:MFCD00079297

Structural formula:

Origin: China

Application: Stomach Ulcers /Erosive Esophagitis/Gastroesophageal Reflux Disease

Delivery Time: in stock

Technical Specification

Package: 1kg; 25kg

Storage: Store in tight, light- resistant holders, avoid exposure to direct sun, humidity and inordinate heat.

Shelf Life 24 months

Pharmacological action

Famotidine API is an effective and long- lasting H2 receptor blocker of the guanidine thiazole class, characterized by high affinity for H2 receptors, and its medium of action is analogous to that of cimetidine. it can effectively inhibit gastric acid stashing caused by rudimentary gastric acid, nightly gastric acid, and food stimulants. It can also inhibit gastric acid stashing caused by stimulants similar as histamine and pentapeptide gastrin. Its inhibition of H2 receptors is 20 times stronger than cimetidine and7.5 times stronger than ranitidine. In addition, it can also inhibit the stashing of gastric protease. it has no effect on androgens and interferes with medicine metabolism enzymes.

Pharmacokinetics

Famotidine powder is fleetly but partly absorbed orally, with an oral bioavailability of roughly 50, and isn't affected by food. After oral administration, it takes about 1 hour to take effect, and the blood medicine attention reaches its peak at 2- 3 hours. The duration of action is about 12 hours or further. it is extensively distributed in the body, with high attention in the digestive tract, feathers, liver, submandibular glands, and pancreas, but doesn't access the placental hedge. The tube protein list rate is 15 to 20. Both oral and intravenous administration have a half- life of 3 hours, and the half- life is dragged in cases with renal insufficiency. A small quantum of it is metabolized into S- oxide in the liver, and utmost of it's excreted from the feathers in its original form, with a small quantum of corrosiveness excretion. The urinary excretion rates of the original medicine within 24 hours after oral and intravenous administration were 35 to 44 and 88 to 91, independently. it can also be excreted through milk, and its medicine attention is analogous to that in tube. it doesn't inhibit liver medicine metabolism enzymes, thus it doesn't affect the metabolism of medicines similar as theophylline, phenytoin sodium, warfarin, and diazepam, nor does it affect the in vivo distribution of procaine amine.

Indications

Famotidine is an effective and long- acting third- generation histamine H2 receptor blocker with high receptor affinity. It can effectively inhibit gastric acid stashing caused by rudimentary gastric acid, nightly gastric acid, and food stimulants. It can also inhibit gastric acid stashing caused by histamine and pentapeptide gastrin. It's suitable for gastric and duodenal ulcers, anastomotic ulcers, stress ulcers, influx esophagitis, Zhuo Ai pattern, and upper gastrointestinal bleeding.

Application

Histamine H2 receptor antagonist, with strong selectivity, can persistently inhibit gastric acid stashing. Stronger effect, longer conservation time, wide safety range, without anti androgen and snooping with medicine metabolism enzymes. Its negative effect is further than 30 times that of cimetidine and 14 times that of ranitidine. The lozenge used is only1/20 of cimetidine and1/7 of ranitidine. Used for peptic ulcer complaint, gastric and duodenal ulcers, influx esophagitis, upper gastrointestinal bleeding,etc.

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In summary, Xi'an Yihui company as a professional Famotidine API manufacturer has strong technical strength and advanced production equipment and is committed to providing customers with high-quality, efficient and reliable drug raw materials. if you need Famotidine powder, pls feel free to contact us any time. we will reply you ASAP.

Our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937