Atracurium Besylate

CAS: 64228-81-5
Appearance: white powder
Standard: usp
Application: Muscle Relaxants
Brand: YIHUI
Packing: 100g;1kg
Supply Ability: 20kg per month
Delivery Time: Ready Stock in Local Warehouse,1-3 days
Origin:China
Shipping:DHL,FedEx,TNT,EMS,By Sea,By Air
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Product Introduction

What is Atracurium Besylate

The Atracurium Besylate, a neuromuscular-blocking agent, plays a pivotal role in various medical applications. Yihui's product is manufactured with precision, ensuring optimal efficacy and safety. This drug item is broadly perceived for its capacity to prompt muscle unwinding during surgeries, making it an irreplaceable apparatus in the field of sedation.

It(64228-81-5) is a crucial pharmaceutical product known for its muscle-relaxant properties. Yihui, a reputable manufacturer and supplier, takes pride in producing high-quality product, adhering to stringent international standards, and holding certifications such as ISO, Kosher, Halal, and GMP. This introduction aims to provide comprehensive insights into the product, catering to the needs of professional buyers and global dealers.


Basic Information

Product Name: Atracurium besilate

CAS: 64228-81-5

MF:C65H82N2O18S2

MW:1243.48

EINECS:264-743-4

MDL No.:MFCD00797403

Purity: 99%

Package: 1KG ;5kg

Used: Pharma grade &Lab research

Stability: Stable

Structural formula:

64228-81-5.webp

Specifications and Parameters

TEST

STANDARD

RESULT

Appearance

White to yellowish-white powder, slightly   hygroscopic, odorless.

Conforms

Very soluble in acetonitrile , in ethanol   (96 percent ) and in methylene chloride; soluble in water.

Conforms

Identification

(1) IR

Conforms

(2) HPLC

Conforms

Water

NMT 5.0%

0.9%

Residue on ignition

NMT 0.2%

0.05%

Methyl benzenesulfonate

NMT 0.01%

Undetected

Toluene

NMT 890ppm(ICH)

122ppm

Chromatographic purity

(1) Laudanosine: NMT 0.5%

0.05%

(2) Any other individual impurity: NMT   1.0%

0.32%

(3) Total impurities: NMT 3.5%

0.65%

Isomer ratio

(1) trans-trans isomer: 5.0% ~ 6.5%

5.6%

(2) cis-trans isomer: 34.5% ~ 38.5%

36.1%

(3) cis-cis isomer: 55.0% ~ 60.0%

58.3%

Assay

96.0% ~102.0% (C65H82N2O18S2 on the   anhydrous basis)

100.1%

Residual solvents

(1)Dichloromethane: NMT 600ppm

9ppm

(2)Acetonitrile: NMT 410ppm

Undetected

(3)Ethyl ether: NMT 5000ppm

166ppm

Heavy metals

NMT 20ppm

Conforms

Result: Conforms to USP .


Storage: Preserve in tight,   light-resistant containers, in a cold place.



Chemical Composition

ComponentPercentage Composition
Atracurium Besylate75%
Excipients25%

Role and Function 

It is a medication that belongs to a class of drugs called nondepolarizing neuromuscular blocking agents. It is basically utilized during surgeries to incite muscle unwinding and work with endotracheal intubation.Here are the role and functions :

  • Neuromuscular Blockade: It acts as a competitive antagonist at the motor end plate of skeletal muscles, blocking the transmission of nerve impulses from motor neurons to skeletal muscle fibers. This results in skeletal muscle relaxation and paralysis.

  • Facilitating Intubation: One of the key roles of the product is to aid in endotracheal intubation. By inducing muscle relaxation, it helps to facilitate the insertion of a breathing tube into the trachea, allowing for controlled ventilation during surgery or other medical procedures.

  • Surgical Muscle Relaxation: It is frequently used to achieve and maintain muscle relaxation during surgical procedures. This is especially significant in medical procedures where muscle unwinding is required, like stomach a medical procedure or muscular methods, to work on careful access, forestall muscle withdrawals, and work with legitimate situating of the patient.

  • Adjunct to Anesthesia: The product is often administered as an adjunct to general anesthesia. By producing muscle relaxation, it helps to complement the effects of anesthesia, ensuring optimal conditions for surgical procedures, reducing the risk of patient movement, and enhancing surgical precision.

  • Reversible Action: Unlike depolarizing neuromuscular blocking agents, such as succinylcholine,it can be reversed with medications like neostigmine or sugammadex. This allows for the reversal of muscle relaxation after the procedure is completed, restoring normal muscle function.

Synthesis Process 

The synthesis of the 64228-81-5 involves a multi-step process starting with the combination of specific chemical compounds. The reaction undergoes purification and isolation stages to ensure the final product meets the highest quality standards. Yihui employs state-of-the-art technology and follows strict protocols to guarantee the purity and effectiveness of the synthesized product.

Quality Standards 

Yihui is committed to maintaining the highest quality standards for this product. Our assembling processes are in severe consistence with global guidelines, and each group goes through thorough testing for immaculateness, security, and wellbeing. The product conforms to the specifications outlined in pharmacopeias and meets the expectations of discerning healthcare professionals.

Application Fields in Various Industries 

Atracurium Besylate finds widespread application in the medical field, particularly in anesthetic procedures. Its precise muscle-relaxant properties make it a vital component in surgeries where muscle control is essential. Here are some specific applications of this product:

  • General Anesthesia: It is commonly used as part of a balanced anesthesia regimen. It is administered intravenously to achieve muscle relaxation and facilitate surgical access, especially in procedures that require complete immobilization or where patient movement may interfere with surgical precision.

  • Endotracheal Intubation: It plays a crucial role in facilitating endotracheal intubation, which involves placing a breathing tube into the trachea to establish a secure airway during general anesthesia. By inducing muscle relaxation, it reduces resistance and allows smooth insertion of the endotracheal tube.

  • Maintaining Muscle Relaxation: During surgical procedures, continuous muscle relaxation is often required to optimize surgical conditions. it can be administered as an infusion to maintain the desired level of muscle paralysis throughout the surgery, ensuring optimal surgical access and reducing the risk of spontaneous muscle contractions.

  • Reversal of Muscle Relaxation: After the surgical procedure is complete, the effects of the product can be reversed using medications such as neostigmine or sugammadex. These reversal agents help restore normal muscle function by counteracting the effects of the neuromuscular blockade induced by this product.

Additionally, the pharmaceutical industry values the product for its consistent quality, ensuring reliability in formulations.

Contact Us

Yihui, as a distinguished Atracurium Besylate manufacturer, prioritizes quality and international standards. Our commitment to ISO, Kosher, Halal, and GMP certifications underscores our dedication to delivering pharmaceutical excellence. For inquiries or purchases, contact us at sales@yihuipharm.com. Choose Yihui for unparalleled quality in the product.


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