We supply Telithromycin

We're proud to offer high- quality Telithromycin to meet your medicinal needs. Our product is manufactured to strict norms to insure chastity and effectiveness. As a trusted supplier, we're committed to furnishing excellent service and timely delivery to our guests worldwide. it has been used successfully to treat a wide range of bacterial infections, making it an essential element in moment's medical assiduity. Trust us to give you with the stylish Telithromycin that will meet all your requirements. communicate us moment for further information and to place your order.

What's Telithromycin ?

Telithromycin is a important antibiotic drug that belongs to the macrolide class of antibiotics. This drug is used to treat a wide range of bacterial infections including respiratory tract, skin, and soft towel infections. it works by inhibiting the growth and spread of bacteria, furnishing relief from the symptoms of bacterial infections.

This drug is available in the form of tablets and is generally taken orally. It's important to take it exactly as specified and to finish the full course of treatment to effectively treat the infection. The lozenge and duration of treatment will depend on the inflexibility of the infection.

it is known to be effective against several antibiotic- resistant strains of bacteria, making it a precious tool in treating infections that are delicate to manage with other antibiotics. It is, still, important to note that it may not be effective against all strains of bacteria.Like all specifics, it may beget side goods in some people. Common side goods include nausea, diarrhea, stomach pain, and headaches. While utmost side goods are mild and resolve on their own. In summary, it is a macrolide antibiotic that's effective in treating a wide range of bacterial infections.

Basic Information

Product Name: Telithromycin

CAS: 191114-48-4

MF:C43H65N5O10

MW:812

EINECS:682-750-4

MDL No.:MFCD04117983

MDL No.:MFCD00866235

Structural formula:

Origin: China

Application: Antibiotic <br>

Purity: ≥98%<br>

Delivery Time: in stock

Technical Specification

Package: 1g; 5g ;10g or according to your demands

Storage conditions: Store in a cool and dry area and keep away from direct light.

Transportation conditions: Transportation at room temperature

Shelf Life: 24 months

Macrolide antibiotics

Telithromycin is a new type of macrolide antibiotic developed in recent times. It's the first antibacterial medicine in the semi synthetic macrolide lincomycin chain yangmycin B( MLSB) family and also the first ketolide antibiotic approved for clinical use. It was successfully developed by the French Sanofi Anvante group and has broad- diapason antibacterial exertion and low picky resistance. It has good remedial goods on Streptococcus pneumoniae, its resistant strains to penicillin and erythromycin, pneumococci, influenza influenzae, and Morahamus, and its antibacterial effect is stronger than that of macrolide antibiotics similar as azithromycin. It's substantially used to treat respiratory infections, bronchitis, and pharyngitis. Tonsillitis and pneumonia. its medium of action is analogous to that of macrolide antibiotics, substantially by directly binding to the 50s subunit of bacterial ribosomes, inhibiting protein conflation, and inhibiting its restatement and assembly. It can also bind to nucleotides in the II and V structural regions of 23s ribosomal RNA, but the biggest difference is that it has a stronger list force to wild- type ribosomes than erythromycin and clarithromycin, which are about 10 and 6 times stronger, independently. The slight difference in the revision of ribosomal structure V region increases the forbearance of MLSB antibiotics to bacteria by 20 times, making them effective against all resistant strains of macrolides.

Oral immersion is good, with an oral bioavailability of about 57. Food doesn't affect its immersion, and 70 is metabolized by CYP3A4 in the liver to form thalidol, thalic acid, N- demethoxyamide derivations, and N- oxpyridine derivations. T1/ 2 is9.81 hours, and the renal concurrence rate is12.5 L/ h. There are multiple ways of excretion 13 is excreted in its original form from urine, 3 is excreted in its original form from feces, and 37 of metabolites are excreted from the liver. In cases with liver dysfunction, Cmax diminishments by about 20, T1/ 2 is1.4 times longer than normal, and metabolic rate also decreases. The average pharmacokinetic parameters measured in cases with community- acquired pneumonia( CAP) were Cmax of2.89 mg/ L, Cmin of0.19 mg/ L, and AUC of13.9 mg/( L · h). On February 12, 2007, the US Food and Drug Administration blazoned certain variations to the medicine marker of the antibiotic Talithromycin( also known as Kenlik) produced by Sanofi Anvante. The suggestions for this medicine, acute bacterial sinusitis and acute bacterial deterioration of habitual bronchitis, were removed from the medicine marker, and cases were reminded to use it safely.

Medium of Action

it works by inhibiting bacterial protein conflation. It binds to the 50S ribosomal subunit of susceptible bacteria, specifically targeting disciplines II and V of the 23S rRNA within the ribosome. This binary list medium results in a more robust inhibition of protein conflation compared to traditional macrolides, which generally bind only to sphere V. By precluding the extension of the protein chain, it effectively halts bacterial growth and replication.

Spectrum of Activity

it is effective against a wide range of Gram-positive and some Gram-negative bacteria. Its diapason includes

• Gram-positive bacteria

Streptococcus pneumoniae( including penicillin- resistant strains)

Streptococcus pyogenes

Staphylococcus aureus( methicillin-sensitive)

• Atypical pathogens

Mycoplasma pneumoniae

Chlamydophila pneumoniae

Legionella pneumophila

• Some Gram-negative bacteria

Haemophilus influenzae

Moraxella catarrhalis

Clinical Uses

it is primarily indicated for the treatment of respiratory tract infections, similar as

• Community- acquired pneumonia( CAP)
• Acute bacterial sinusitis
• Acute exacerbations of habitual bronchitis

It's important to note that due to enterprises over safety, its use has been limited in some countries. Adverse goods, particularly serious hepatotoxicity and exacerbation of myasthenia gravis, have led to restrictions on its use.

Resistance

Despite its efficacity, resistance to it can do, generally through variations to the ribosomal target point, efflux pumps, or enzymatic declination. The unique list parcels of telithromycin, still, make it less susceptible to resistance mechanisms that affect aged macrolides.

Side Effects

Common Side Effects include

• Gastrointestinal disturbances( nausea, puking, diarrhea)
• Headache
• Dizziness

Serious but less common side goods can include

• Liver toxin
• Visual disturbances
• Implicit exacerbation of myasthenia gravis

Due to these implicit side goods, careful consideration and monitoring are needed when defining it, particularly in cases withpre-existing liver conditions or myasthenia gravis.

it is a potent antibiotic with a broad diapason of exertion against colorful respiratory pathogens. still, its use is tempered by enterprises over implicit severe side goods, challenging caution and monitoring in clinical practice.

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