We supply Topotecan Hydrochloride API

We specialize in the force of Topotecan Hydrochloride, a largely potent medicine used in the treatment of colorful types of cancer. Our API is sourced from top manufacturers and is of the loftiest quality. We insure that our product meets all applicable assiduity norms and regulations. it is known to have a high success rate in the treatment of ovarian, small cell lung, and cervical cancer. Our API is available in bulk for expression or exploration purposes. communicate us moment to learn further about our product and how it can profit your design or treatment.

What's Topotecan Hydrochloride?

Topotecan hcl is a potent and picky cytotoxic medicine used in cancer chemotherapy. This API is a water-answerable,semi-synthetic analog of camptothecin, a naturally being alkaloid insulated from the dinghy of the tree Camptotheca acuminata. Approved by the FDA in 1996, the medicine is indicated for use as a alternate- line treatment for small cell lung cancer, ovarian cancer and, more lately, cervical cancer.

it works by inhibiting the exertion of topoisomerase I, an enzyme essential for DNA replication and form. By inhibiting the exertion of this enzyme, Topotecan induces double- stranded DNA breaks, leading to cell death and reduction in excrescence size. The medicine has been successful in treating colorful types of cancer, and is particularly effective against ovarian and small cell lung cancer. also, it has been shown to ameliorate progression-free survival and overall survival in cases with regressed cervical cancer.

In summary, it is a potent and picky cytotoxic medicine that has shown success in treating multiple types of cancer. Its unique medium of action and clinical efficacity make it an important agent in the operation of several oncologic conditions.

Basic Information

Product Name: Topotecan hydrochloride

CAS: 119413-54-6

MF:C23H24ClN3O5

MW:457.91

EINECS:601-607-9

MDL No.:MFCD00866235

Structural formula:

Origin: China

Application: Anti-Tumor <br>

Purity: ≥99%<br>

Delivery Time: in stock

Technical Specification

Package 10g; 50g; 100g or according to your demands

storehouse conditions Store in a cool and dry area and keep down from direct light.

Transportation conditions Transportation at room temperature

Shelf Life 24 months

Antitumor medicines

Topotecan hydrochloride is a water-answerable outgrowth of camptothecin, in the form of a hydrochloride of Topotecan. It was successfully developed by SmithKlineBeecham in the United States and was approved by the FDA for trade in the United States in 1996. The medicine is retailed as Hycamtin and is used as a alternate- line treatment for ovarian cancer( OVC). In 1999, the US Food and Drug Administration( FDA) approved it as a remedial medicine for small cell lung cancer( SCLC), which has been retailed in dozens of countries and regions similar as the UK, Germany, and France. The phase III clinical trial of this medicine for the treatment ofnon-small cell lung cancer, cervical cancer, and myelodysplastic pattern is still ongoing. it can enter the blood- brain hedge, and its oral and intravenous injection goods are the same. This medicine has low predictable bone gist suppressive toxin, while other non blood toxin is fairly mild. At present, there are manufacturers in China that produce it for clinical treatment of excrescences similar as small cell lung cancer and ovarian cancer. it can inhibit the exertion of topoisomerase I, which is needed for DNA replication. After intravenous injection, this product is hydrolyzed in the blood and excreted through urine. This product has a rapid-fire serum concurrence rate of 62L per hour, extensively distributed in the body, and a half- life of about 2- 3 hours. Preclinical trials have shown that this product hasanti-tumor exertion against colorful types of excrescences. In the Phase I clinical trial, this product also showed significantanti-tumor goods on cisplatin tolerant ovarian cancer cases.

Biological activity

Topotecan hcl is a chemotherapeutic medicine used to treat colorful types of cancer. It's asemi-synthetic outgrowth of camptothecin, an alkaloid emulsion set up in the dinghy and stem of the Camptotheca acuminata tree. it is known for its potentanti-cancer exertion and has been approved by theU.S. Food and Drug Administration( FDA) for the treatment of ovarian and small cell lung cancers.

it works by snooping with the replication process of cancer cells. The medicine targets a specific enzyme called topoisomerase I, which is responsible for unwinding and rewinding DNA during cell division. By inhibiting topoisomerase I, it causes DNA damage and prevents cancer cells from dividing and growing.

its Biological activity is determined by its capability to inhibit topoisomerase I and induce apoptosis, or cell death, in cancer cells. The medicine has been shown to be effective against a wide range of cancers, including ovarian, small cell lung, cervical, and bone cancers.

it is administered intravenously and is generally given in cycles of treatment, with a period of rest in between. The medicine is frequently used in combination with other chemotherapy medicines to increase its effectiveness.

As with any chemotherapy medicine, it can beget side goods. Common side goods include nausea, puking, fatigue, and hair loss. More serious side goods, similar as bone gist repression, infections, and antipathetic responses, may do in some cases.

Overall, it is a important and effective chemotherapy medicine that has been proven to be a precious tool in the treatment of cancer. Its natural exertion, which stems from the inhibition of topoisomerase I and induction of apoptosis, makes it a crucial element of numerous cancer treatment rules.

Application

it is a chemotherapy drug primarily used in the treatment of certain types of cancer. Then are some specific operations

• Small Cell Lung Cancer( SCLC):  it is frequently used for cases with small cell lung cancer, particularly those who have regressed after original chemotherapy.
• Ovarian Cancer: It's also used in the treatment of ovarian cancer, especially for cases whose complaint has persisted or reenacted after original or posterior chemotherapy.
• Cervical Cancer: it can be used in combination with cisplatin for the treatment of late- stage( stage IV- B), intermittent, or patient cervical cancer.
• Other Cancers:  Research and clinical trials explore its use in other cancers, similar as certain types of leukemia and retinoblastoma, though these uses may not be as well established.

Medium of Action

it works by inhibiting the enzyme topoisomerase I, which is essential for DNA replication. By snooping with this enzyme, topotecan induces breaks in the DNA beaches, precluding the cancer cells from replicating and leading to cell death.

Administration

it can be administered either intravenously( IV) or orally. The specific lozenge and treatment schedule depend on the type of cancer being treated, the stage of the complaint, and the case’s overall health and response to remedy.

Side Effects

Common side goods include

• Nausea and puking
• Diarrhea or constipation
• Hair loss
• Fatigue
• Myelosuppression( dropped product of blood cells), leading to increased threat of infection, anemia, and bleeding.

Payment Term

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In summary, as a professional Topotecan hydrochloride manufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make it stand out in the market competition and win more customer trust and support. if you need Topotecan hcl , pls feel free to contact us any time. we will reply you asap.

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E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
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