We supply Paliperidone API

Paliperidone API is a high- quality active pharmaceutical component that we supply for pharmaceutical companies. Our Paliperidone meets the high chastity norms needed in the pharmaceutical assiduity and is suitable for the conflation of colorful pharmaceutical products. it is a well- known medicine used for the treatment of schizophrenia and related diseases, and our API is an essential component in the product of this drug. With our dependable and high- quality Paliperidone, pharmaceutical companies can insure the thickness and effectiveness of their products, perfecting patient issues and satisfaction. communicate us moment to learn further about our Paliperidone.

What's Paliperidone API?

Paliperidone has a chemical formula of 3-( 2-( 4-( 6- fluoro -1,2-benzoxazole-3-yl) piperidin-1-yl) ethyl)( 1,2- a) pyrimidin-4-one, with a molecular formula of C23H27FN4O3 and a viscosity of1.45 g/ cm3. It's a white or pale to slightly unheroic greasepaint and is clinically used to treat schizophrenia and schizophrenic affective diseases.

Basic Information

Product Name: Paliperidone

CAS: 144598-75-4

MF:C23H27FN4O3

MW:426.48

EINECS:620-493-1

MDL No.:MFCD00871802

Structural formula:

Application: Anti-Schizophrenia

Origin: China

Delivery Time: in stock

Technical Specification

Package 100g; 1kg, or according to your demands

Storage conditions: Preserve in tightly closed container between 2～8℃

Transportation conditions: Transportation at room temperature

Shelf Life: 24 months

Application

Paliperidone API, an atypical antipsychotic, is used primarily in the treatment of colorful psychiatric diseases. The active pharmaceutical component( API) has several important applications

1. Schizophrenia

it is extensively used to treat schizophrenia, a severe internal complaint characterized by distorted thinking, feelings, and geste. It helps palliate symptoms similar as visions, visions, disorganized thinking, and emotional insecurity, thereby perfecting the quality of life and social functioning of cases.

2. Schizoaffective complaint

it is approved for the treatment of schizoaffective complaint, a condition encompassing symptoms of both schizophrenia and mood diseases similar as depression or bipolar complaint. It helps manage both the psychotic and mood symptoms effectively.

3. Bipolar complaint

it can be used to treat manic or mixed occurrences associated with bipolar I complaint. It aids in stabilizing mood, reducing manic symptoms, and perfecting overall emotional stability in cases.

4. Long- Amusement Injectable phrasings

it is available as a long- acting injectable( LAI) that can be administered yearly or indeed less constantly. This expression is particularly useful for perfecting drug adherence and icing harmonious remedial goods, reducing the threat of relapse and hospitalization.

5. conservation remedy

As part of conservation remedy, it helps help the rush of psychotic occurrences in cases with schizophrenia or schizoaffective complaint. nonstop treatment with it can help maintain symptom stability and reduce the frequence and inflexibility of acute occurrences.

6. Cognitive Function enhancement

Some studies suggest that it may have positive goods on cognitive functions in cases with schizophrenia. perfecting cognitive poverties can enhance the overall functional outgrowth and quality of life for these cases.

7. Lower Risk of Metabolic Side goods

Compared to some other antipsychotic specifics, it has a fairly lower threat of certain metabolic side goods, similar as significant weight gain and diabetes. This makes it a preferable option for cases who are sensitive to these side goods.

Pharmacological action

Paliperidone is the main metabolite of risperidone. The medium of action isn't yet clear, but it's presently believed to be intermediated through a concerted effect of enmity against central dopamine 2( D2) receptors and serotonin 2( 5HT2A) receptors. it is also an antagonist of nascence 1 and nascence 2 adrenergic receptors, as well as H1 histamine receptors, which may be the reason for some other goods of the medicine. it has no affinity for cholinergic muscarinic receptors or β 1- and β 2- adrenergic receptors. In vitro, the pharmacological goods of() and(-)- palipidone enantiomers are analogous.

Biological activity

Paliperidone As the main active metabolite of Risperidone, it's an effective serotonin- 2A and dopamine- 2 receptor antagonist used for the treatment of schizophrenia.

In vitro exploration

The attention dependence of Paliperidone significantly increases the accumulation of Rh123 and DOX in cells. it acts well on A β( 25- 35) and MPP() at low attention( 10 and 50 μ M), and only protects SH- SY5Y from hydrogen peroxide damage. Paliperidone( 100 μ M) fully reduces cell reduction convinced by different pressures, anyhow of its lozenge. it has a advanced oxidative stress concurrence effect than other APDs in numerous aspects, similar as producing large quantities of glutathione, low HNE, and protein carbonyl products. it enhances dopamine toxin at the loftiest cure and is the only AP, significantly adding cell exertion(8.1%) compared to cells treated with dopamine alone.

In vivo exploration

Paliperidone restores extracellular glutamate in the rudimentary subcaste of the prefrontal cortex of rats. In rats, it also prevents acute MK- 801 convinced increase in extracellular glutamate. The concerted administration of Paliperidone and Escitalopram restored the inhibition of NE neuron discharge rate and the chance of unforeseen neuronal discharge. it reduces smelling and aggressive geste in a cure-dependent manner at effective boluses. it leads to a significant reduction in attack geste.

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Yihui takes pride in being a trusted Paliperidone API manufacturer and supplier. To acquire this groundbreaking product or discuss your specific requirements, contact us immediately at sales@yihuipharm.com. Rest assured, with Yihui, you're accessing a product of unparalleled quality, backed by certifications that underscore our commitment to excellence in the global market.