Ezetimibe API
Package: 500g/bag;1kg/bag
Origin: China
Supply Ability: 100kg per month
Sample Available: Yes
Shelf Life: Two years
Payment: T/T, LC or DA
Certifications: ISO9001, ISO22000, HACCP, HALAL, KOSHER
Third Party Test: available
Plant Audition: available
Can’t sell to individuals
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Product Introduction
Ezetimibe API Supplier
Xi'an Yihui Company is a professional manufacturer of Ezetimibe. We can generate Ezetimibe API with a 99.9% content. It can be utilized in food, medicine, health care items, or cosmetics and meet USP, BP, EP,CP standards. We can offer you products of the highest caliber at the most competitive rates. Your best option for a reputable pure Ezetimibe supplier is Xi'an Yihui Company!
What Is Ezetimibe API?
Ezetimibe API is a raw material medicine used to treat high cholesterol and atherosclerosis, it Reduces cholesterol situations by inhibiting the immersion of cholesterol in the gut. it's a white crystalline solid, odorless, and slightly answerable in water. Its chemical name is( 3R, 4S)- 1-( 4- fluorophenyl)- 3-(( 3S)- 3-( 4- fluorophenyl)-3-hydroxypropyl)- 4-( 4- hydroxyphenyl)-2-azetidinone, its molecular formula is C24H21F2NO3, its molecular weight is409.4 Dalton, and its CAS number is 163222-33-1. it's a cholesterol immersion asset that substantially acts on the Niemann- Pick C1- suchlike 1( NPC1L1) transporter protein in the small intestine, blocking its immersion of cholesterol.In addition, it can also promote the breakdown of cholesterol in the liver, thereby further reducing cholesterol situations in the blood.
it was first developed by MSD Pharmaceuticals in the United States, and its exploration and development process lasted for roughly 10 times. The medicine was first approved by the FDA to treat hypercholesterolemia and atherosclerosis in 2002.
In 2008, Ezetimibe became one of Merck's main products. Since then, Merck has further promoted the use of the medicine and launched deals worldwide.
In addition to the single-cure oral tablet form, Merck &Co., Inc. has also developed combination phrasings containing statins to further lower cholesterol situations in the blood.
Overall, It has become an important medicine for the treatment of hypercholesterolemia since its launch. it's furnishing an effective treatment for millions of cases worldwide.
Basic Information
Product name | Ezetimibe |
Other name | EzetiMib;ZETIA;(3R,4S)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one;Ezetimibe-001;(3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one;CS-1965; |
CAS | 163222-33-1 |
MF | C24H21F2NO3 |
MW | 409.43 |
EINECS | 682-606-0 |
MDL No. | MFCD00937872 |
Purity | 99% |
Stability | stable when stored under appropriate conditions. |
solubility | Soluble in DMSO and Ethanol |
Application | Medicine grade or used for research. |
Packing | As per your request |
Storage | Room temp. |
Structural formula |
Quality standard
Item | Specification | Results |
Appearance | A white to off-white crystalline powder, odorless | Complies |
Solubility | Easily soluble in ethanol and methanol, soluble in acetonitrile and isopropyl alcohol, insoluble in water | Complies |
Identification | A. HPLC: RRT test solution is similar to RRT reference solution | Complies |
B: IR: similar to reference | Complies | |
Melting range | 162℃ to 165℃ | 163℃ to 164℃ |
Specific rotation(20℃) | -25.0°~-29.0° | -26.6° |
Fluorine | 8.4%~10.2% | 8.6% |
Water | NMT 5.0% | 0.17% |
Residue on ignition | NMT 0.2% | 0.04% |
Heavy metals | NMT 0.002% | Complies |
Related substance | Impurity A NMT0.15% | Not detected |
Impurity B NMT0.15% | 0.02% | |
Impurity C+D NMT0.15% | 0.10% | |
Impurity E NMT0.15% | 0.02% | |
Impurity F NMT0.15% | 0.002% | |
Any unknown impurity NMT 0.10% | 0.01% | |
Total impurities NMT 0.9% | 0.15% | |
Enantiomer | NMT 0.1% | Not detected |
Residual solvents | Isopropyl alcohol NMT 5000ppm | 629ppm |
dichloromethane NMT 600ppm | 20ppm | |
MTBE NMT 5000ppm | 6ppm | |
ethyl acetate NMT 5000ppm | 12ppm | |
Assay | 98.0%~102.0%(calculated on dried basis ) | 99.9% |
Conclusion | The results above meet in-house standard |
Fouctions and applications
Ezetimibe API is a drug used to treat high cholesterol situations in the blood. It works by reducing the quantum of cholesterol that's absorbed into the body from food, which can help lower overall cholesterol situations.
Then are some crucial features and operations of Ezetimibe
1. Reduces cholesterol immersion Ezetimibe blocks the immersion of cholesterol from the small intestine, which can help lower the quantum of cholesterol in the bloodstream.
2. Lowers LDL cholesterol Ezetimibe can reduce situations of low-viscosity lipoprotein( LDL) cholesterol, also known as" bad" cholesterol. High situations of LDL cholesterol increase the threat of heart complaints and stroke.
3. Increases HDL cholesterol Ezetimibe can also increase situations of high-viscosity lipoprotein( HDL) cholesterol, also known as" good" cholesterol. High situations of HDL cholesterol are associated with a lower threat of heart complaints.
4. Combination remedy Ezetimibe can be used alone or in combination with other cholesterol-lowering specifics, similar as statins, to further reduce cholesterol situations.
5. Prevents cardiovascular events Lowering cholesterol situations with ezetimibe has been shown to reduce the threat of cardiovascular events, similar as heart attacks and strokes, especially in people who have formerly endured a cardiovascular event.
6. Well-permitted Ezetimibe is generally well-permitted, with many side goods reported. still, it may interact with certain specifics, so be sure to let your croaker know about all the specifics you're taking.
Overall, ezetimibe is an effective drug for reducing cholesterol situations and reducing the threat of cardiovascular events.
Stability & Storage
Ezetimibe can be kept at a high position of stability when stored in a dry state at 25 ℃. Experimental results show that the dry powder sample can maintain a chastity of over 90 indeed after 2 times of storehouse at room temperature. still, exposure to high temperature, high moisture, and light can lead to corruption and declination, which can affect its content.
So, it should be kept down from high temperature, high moisture, and light as much as possible. At the same time, during storehouse and transportation, its blankness, humidity resistance, and light avoidance characteristics should be maintained to ensure its quality and effectiveness.
its storage conditions should follow these guidelines:
Temperature It should be stored at room temperature( 15 °C
30 °C), avoiding exposure to high or low-temperature surroundings.
moisture Avoid damp and sticky surroundings, and store in a dry terrain with relative moisture not exceeding 60.
Light Avoid direct sun and violent fluorescent beacon irradiation to help chemical changes that may affect medicine quality.
Packaging Maintain the integrity and airtightness of the medicine to help air pollution or water doorway that may beget a drop in medicine quality.
Storage position Store it in a dry, voiced, light-avoiding, humidity-evidence, and odorless place, down from dust and other dangerous adulterants.
Packing & Shipping
Packing: 1kg/foil bag;5kg/carton;25kg/fiber drum; or packing as your request.
Customization: Customized logo; Customized packaging; Graphic customization
Shipping:
Item | Quantity | ETA time | Shipping Method |
By Courier | ≤50kg | 7-15days | Fedex, DHL,UPS,TNT,EMS ect. Fast and convenient |
By Air | 50kg~200kg | 3-5days | Fast and cheap |
By Sea | Large quantity | 20-35days | Cheapest way |
Payment Term
Why Choose Xi'an Yihui?
Customer feedback
Xi'an Yihui certificates
Xi'an Yihui Factory & Warehouse
Our Advantage
Rich experience: we have 13 Years of professional experience;
Customers all over the world: sell to more than 100 countries;
Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.
Price advance: low MOQ with competitive price;
Quality certification: ISO; Halal; Kosher certified
After-sales service: Professional team 7*24 hours customer service.
In conclusion
In summary, Xi'an Yihui company as a professional Ezetimibe API manufacturer has strong technical strength and advanced production equipment and is committed to providing customers with high-quality, efficient and reliable drug raw materials. if you need it, pls feel free to contact us any time. we will reply you asap.
if you need it, pls feel free to contact us any time. we will reply you asap.
our contact information:
E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937
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