We supply Tildipirosin API

Our company is proud to offer Tildipirosin API, a potent and effective antibiotic used in the treatment of respiratory infections in swine. Our high- quality product offers dependable results and is backed by our commitment to furnishing exceptional client service and support. Trust in our moxie in the antibiotic assiduity and choose our Tildipirosin  for your veterinary requirements. communicate us moment to learn further about our product and how we can help you attack the challenges of beast health and complaint forestallment.

What is Tildipirosin?

Tildipirosin powder is a new semi synthetic beast specific 16 membered ring macrocyclic lactone antibiotic, first developed by Intervet transnational BV as a outgrowth of tetracycline.

it is the rearmost semi synthetic macrolide antibiotic specifically designed for creatures, which is a outgrowth of Tylosin. The molecular formula is C41H71N3O8, with a molecular weight of 734.02. It's a white to light unheroic greasepaint and exists in a polycrystalline form. It's slightly answerable in water and answerable in polar organic detergents similar as methanol and acetone.

Basic Information

Product Name: Tildipirosin

CAS: 328898-40-4

MF:C41H71N3O8

MW:734.02

EINECS:200-292-3

MDL No.:MFCD13194925

Structural formula:

Origin: China

Delivery Time: in stock

Technical Specification

Package: 1kg or 25kg according to your demands

Storage: Preserve in tight,light-resistant containers in cool place

Shelf Life: 2 years

Antibacterial mechanism

The medium of action of Tildipirosin API is analogous to other macrolide medicines, as it can bind to the 50S subunit of ribosomes in sensitive bacteria, inhibit peptide chain conflation and extension by blocking transpeptidation and/ or mRNA relegation, affect bacterial protein conflation, and therefore ply antibacterial and bactericidal goods. Tedroside has a special three nitrogen structure, which allows for faster immersion after injection, stronger penetration of bacterial external walls, and further list spots with bacterial ribosomal proteins, making its antibacterial and bactericidal goods stronger than general macrolide antibiotics. At the same time, its unique trinitrogen structure can protract the effective attention time of Tydelocin in lung towel and bronchial fluid.

Pharmacokinetics

After a single cure intramuscular injection of Tildipirosin injection into the neck, gormandizers were fitted with a single cure of 4mg/ kg body weight. The peak time Tmax in the blood was 23 twinkles, and the peak attention Cmax was 1.12 µ g/ ml. The elimination half- life in tube and lung towel was 4 days and 7 days, independently. Macrolide medicines have targeted particularity in the lungs, with lung towel attention significantly advanced than blood medicine attention. After 24 hours of injection, the peak attention in lung towel reached 4000ng/ g, and after 5 days, the peak attention in bronchial fluid was 14000ng/ g, which is 618 times the medicine attention in blood and has a long- continuing effect. After 14 days, it remained largely sensitive to Pasteurella and Haemophilus parasuis indeed when the lung homogenate exceeded 1000ng/ g and the bronchial fluid attention continued to exceed 6000ng/ g.

Application

Tildipirosin powder is a veterinary antibiotic belonging to the macrolide class, primarily used in beast. Then are some crucial applications

Respiratory Infections: Tildipirosin is effective against bacterial respiratory conditions in cattle and swine, similar as pneumonia.

Bovine Respiratory complaint( BRD): It's generally used for the treatment and forestallment of BRD, which is a significant health issue in beef and dairy cattle.

Swine Respiratory Disease: Tildipirosin can be used to treat respiratory infections in gormandizers, helping to reduce morbidity and mortality in herds.

Injection expression: It's generally administered via subcutaneous or intramuscular injection, allowing for easy use in large beast veterinary practices.

Antimicrobial Stewardship:  Tildipirosin is used in veterinary drug to help manage bacterial infections while promoting responsible use of antibiotics to combat resistance.

Overall, Tildipirosin is an important tool in veterinary drug for controlling contagious conditions in beast, contributing to beast health and weal.

Security research

The administration of conventional boluses( 4- 12mg/ kg body weight) of Tydelocin has no effect on the blood routine, physiological and biochemical pointers of gormandizers, but5-fold injection may beget damage to the heart, liver, and feathers. The exploration results of Lin Hong et al. also indicate that the recommended lozenge for clinical administration is safe, and its clinical use in cattle is also safe; Whether administered intravenously or intramuscularly, Tydelocin is safe for tykes ; Intravenous or subcutaneous injection of 4mg/ kg or 6mg/ kg body weight of Tydelocin in innocents is safe, and may beget mild itching, difficulty breathing, and coughing at the injection point within 2- 10 days after treatment.

In vivo research

In vivo exploration on Tildipirosin primarily focuses on its pharmacokinetics, efficacity, safety, and implicit resistance in beast. Then are some crucial aspects of similar studies

Pharmacokinetics: Studies examine how Tildipirosin is absorbed, distributed, metabolized, and excreted in creatures. This includes its bioavailability, half- life, and towel distribution, which help determine applicable dosing rules.

efficacity Against Respiratory Infections: Research frequently evaluates Tildipirosin's effectiveness in treating bacterial infections, particularly bovine respiratory complaint( BRD) and swine respiratory complaint. Results generally show significant reductions in clinical signs and bettered recovery rates.

Safety and Tolerability: In vivo studies assess the safety profile of Tildipirosin, including any adverse goods in treated creatures. Monitoring for side goods helps establish safe tablets.

Impact on Microbial Resistance: Research investigates how Tildipirosin affects the development of antibiotic resistance in bacterial populations. This includes covering changes in microbial foliage in treated creatures.

relative Studies Some studies compare Tildipirosin with other antibiotics to assess its relative efficacity, safety, and cost- effectiveness in treating infections.

Withdrawal Times: In vivo exploration also determines the applicable pullout ages for meat and milk to insure that remainders are within safe limits for mortal consumption.

Overall, in vivo exploration on Tildipirosin plays a pivotal part in understanding its remedial eventuality and icing responsible use in veterinary drug.

In vitro research

In vitro exploration on Tildipirosin focuses on its antimicrobial parcels, mode of action, and effectiveness against colorful bacterial strains. Then are some crucial aspects of similar studies

Antimicrobial exertion In vitro studies assess the minimal inhibitory attention( MIC) of Tildipirosin against different bacteria, particularly those responsible for respiratory infections in beast, like Mannheimia haemolytica, Pasteurella multocida, and other common pathogens in cattle and swine.

Medium of Action Research frequently explores how Tildipirosin disrupts bacterial protein conflation by binding to the 50S ribosomal subunit, thereby inhibiting bacterial growth.

Bacterial Resistance In vitro studies probe the eventuality for resistance development by exposing bacterial strains tosub-inhibitory attention of Tildipirosin over time. This helps understand the threat of resistance and informs proper application guidelines.

Community Studies Some exploration examines the synergistic goods of Tildipirosin when combined with other antibiotics. This could enhance remedial efficacity and reduce the liability of resistance.

Pharmacodynamics examinations into the pharmacodynamic profile of Tildipirosin give perceptivity into its effectiveness over time against target pathogens under controlled conditions.

Biofilm conformation In vitro models may also be used to study the goods of Tildipirosin on biofilm- forming bacteria, which are frequently more resistant to treatment.

Overall, in vitro exploration plays a pivotal part in establishing the foundational understanding of Tildipirosin's effectiveness and safety, informing its use in veterinary drug.

Packing & Shipping

Packing：1kg/foil bag;5kg/carton;25kg/fiber drum;or packing as your request.

Customization:

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Why Choose Xi'an Yihui?

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In conclusion

In summary, as a professional Tildipirosin API manufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make it stand out in the market competition and win more customer trust and support. if you need Tildipirosin powder, pls feel free to contact us any time. we will reply you asap.

our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937