We supply Ascomycin API

Our company is pleased to offer Ascomycin , a high- quality medicinal component. it is a potent immunosuppressant that's used in the treatment of colorful autoimmune diseases. it is manufactured using strict quality norms to insure its chastity and efficacity. We're confident that our product will meet your conditions and exceed your prospects. Please feel free to communicate us for farther information or to place your order.

What is Ascomycin API?

Ascomycin API is a largely pure and effective emulsion, generally used in the product of a variety of specifics, particularly those used to treat skin diseases similar as eczema, psoriasis, and dermatitis. it is a naturally being, macrolide emulsion that has been uprooted from the turmoil broth of a species of bacteria known as Streptomyces hygroscopicusvar.ascomyceticus. It's known to have a potent immunosuppressive effect by inhibiting the activation of T cells and precluding the release of seditious cytokines.

it is frequently used in the product of topical creams, ointments, and poultices that can be applied directly to the affected skin. It can also be used in oral specifics for the treatment of autoimmune diseases similar as rheumatoid arthritis and Crohn's complaint. Due to its capability to suppress the vulnerable response, it can help to palliate symptoms similar as swelling and greenishness associated with these conditions.

it is a protean emulsion with a wide range of implicit applications in the medical field. Its effectiveness in treating skin diseases has made it a popular choice for pharmaceutical manufacturers and experimenters who are looking to develop new treatments for a range of conditions. With its unique parcels and wide range of implicit applications, it is an important tool for medical professionals who are working to ameliorate the health and good of cases around the world.

Basic Information

Product Name: Ascomycin

CAS: 104987-12-4

MF:C43H69NO12

MW:792.01

EINECS:600-627-5

MDL No.:MFCD06198665

Melting point:153-157°C

Boiling point:868℃

Structural formula:

Origin: China

Delivery Time: in stock

Technical Specification

Package: 5g;10g;100g or according to your demands

Storage conditions: store in alright container below -20℃

Shelf Life:Powder: 2 years

Biological activity

Ascomycin is a macrolide emulsion that has been insulated from the turmoil broth of the fungus Streptomyces hygroscopicusvar. ascomyceticus. It's clinically noted for its immunosuppressive andanti-inflammatory parcels, which make it useful in the treatment of several dermatological diseases similar as psoriasis, atopic dermatitis, and eczema.

It is attributed to its list to the cytosolic immunophilin protein, FKBP12. This list results in the conformation of a complex that specifically inhibits the exertion of the serine/ threonine phosphatase calcineurin. Calcineurin is a crucial middleman of T- cell activation and isolation, and its inhibition results in the reduced recap ofpro-inflammatory cytokines similar as interleukin- 2 and interferon- gamma, therefore leading to a dropped vulnerable response.

piecemeal from its immunosuppressive exertion, It also exhibits significantanti-angiogenesis goods. This is attributed to its capability to inhibit the expression of vascular endothelial growth factor( VEGF), which is essential for angiogenesis. Ascomycin, thus, prevents the conformation of new blood vessels, which is pivotal for the growth and proliferation of excrescence cells.

As a potent immunosuppressive andanti-inflammatory agent, It has been developed as an active pharmaceutical component and is used in the expression of several topical medicine products. These products have shown significant efficacity in the treatment of dermatological diseases, particularly those that are vulnerable- intermediated.

In conclusion, It is a macrolide emulsion that exhibits strong immunosuppressive andanti-inflammatory parcels, making it an important agent in the treatment of several dermatological diseases. Its capability to inhibit calcineurin and VEGF makes it a implicit seeker for the treatment of other conditions characterized by aberrant vulnerable responses or pathological angiogenesis.

Application

It is a potent immunosuppressant that has been used to treat a variety of seditious and autoimmune conditions. As a macrolide emulsion, it exhibits a unique medium of action that inhibits T- cell proliferation and activation by binding to FKBP12, a cytosolic receptor. This prevents T- cell activation and suppresses the vulnerable response to help towel damage and inflammation.

One of the most common applications is in the treatment of psoriasis, a habitual seditious skin complaint that affects millions of people worldwide. By inhibiting T- cell activation, It can help the release of seditious cytokines and reduce the inflexibility of psoriasis symptoms similar as greenishness, scaling, and itching. It's also used to treat atopic dermatitis, a type of eczema that results in dry, itchy, and inflamed skin.

Another application is in the forestallment of transplant rejection. When a case undergoes an organ transplant, the vulnerable system recognizes the transplanted towel as foreign and mounts an attack against it. It can help this rejection by suppressing the vulnerable response and precluding T- cell activation. This allows the transplanted towel to survive and serve duly without being attacked by the vulnerable system.

It is also being delved for its implicit use in the treatment of certain types of cancer. By inhibiting T- cell activation, it may be suitable to help the growth and spread of cancer cells in the body. also, It has shown pledge in treating seditious bowel complaint, a habitual condition that results in inflammation of the digestive tract.

As a potent immunosuppressant, It must be used with caution and under the supervision of a good healthcare professional. It can beget a variety of side goods, including increased vulnerability to infections, increased threat of carcinoma and other cancers, and metabolic diseases similar as diabetes. still, it remains an important tool in the treatment of a variety of seditious and autoimmune conditions and continues to be an active area of exploration.

Agricultural antibiotics

it is a macrolide agrarian antibiotic singly developed by Shanghai Pesticide Research Institute. It's a natural fungicide that can effectively help and treat fungal conditions of colorful crops similar as tomato argentine earth, cucumber argentine earth, and sludge splint spot.

In vitro studies

Ascomycin, insulated from Streptomyces, inhibits the in vitro vulnerable response of mouse mixed lymphocytes with an IC50 of0.55 nM. it inhibits calcineurin through the conformation of the FKBP12- FK520 calcineurin ternary complex with an IC50 of 49nM. FK520 also accelerates the rate of whim-whams form and promotes neurite outgrowth. it exhibits antimalarial goods by inhibiting the molecular chaperone exertion of two different functional proteins.

In vivo studies

Ascomycin(3.2 mg/ kg, intramuscular injection) significantly prolongs the survival rate of skin scattered rats. it, at 50 or 100μM, resists spasms convinced by picrotoxin fitted into the rat hippocampus.

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Yihui takes pride in being a trusted Ascomycin manufacturer and supplier. To acquire this groundbreaking product or discuss your specific requirements, contact us immediately at sales@yihuipharm.com. Rest assured, with Yihui, you're accessing a product of unparalleled quality, backed by certifications that underscore our commitment to excellence in the global market.