We supply Gamithromycin powder

Gamithromycin is a high- quality product that we supply for veterinary use. This antibiotic is effective against a range of respiratory and digestive tract infections in cattle and gormandizers. It has a broad diapason of exertion and has been proven to be veritably effective in treating respiratory conditions similar as pneumonia, bronchitis, and pleurisy. It's also effective against digestive tract infections similar as diarrhea and salmonellosis. it is of the loftiest quality and chastity, icing that it's safe and effective for veterinary use.

What's Gamithromycin?

it is a new type ofsemi-synthetic macrolide veterinary antibiotic. It's one of the representative medicines of the alternate- generation macrolide antibiotics developed by Merial, France. It has antibacterial and bactericidal goods by inhibiting bacterial RNA-dependent protein conflation. it has high antibacterial exertion against hemolytic Mannheimia, Pasteurella multocida and Mycoplasma bovis, which beget bovine respiratory complaint( BRD). It has a broad antibacterial diapason and strong antibacterial exertion. It has the advantages of rapid-fire immersion, wide distribution in the body, low residue in the body and high safety. It's extensively used in the clinical treatment of bovine respiratory conditions caused by bacterial pathogens similar as hemolytic Pasteurella, multocida Pasteurella, and histophilia.

Its chemical name is 13-(( 2,6- dideoxy-3-C-methyl-3-O-methyl-a-L-pyranosyl) oxy)-((- trideoxy- 3-( dimethylamino)- b- D- pyranosyl) oxy)-,( 2R, 3S, 4R, 5S, 8R, 10R, 11R, 12S, 13S, 14R)-1-oxa-7-azacyclo-15-monocycle. It's a white to faceless powder, undoable in water, hygroscopic, stable under high temperature conditions, asleep to light, and has only one configuration after recrystallization. it is substituted by a single propyl group at the 7α position. This special structure facilitates its rapid-fire immersion under physiological pH conditions and maintains a longer duration of action in the target towel, the lung.

Basic Information

Product Name: Gamithromycin

CAS: 145435-72-9

MF:C40H76N2O12

MW:777.05

EINECS:604-472-4

MDL No.:MFCD09954125

Melting point:>118°C (dec.)

Boiling point:833.0±65.0 °C(Predicted)

Structural formula:

Origin: China

Delivery Time: in stock

Technical Specification

Package: 1kg;25kg; or according to your demands

Storage: Preserve in tight,light-resistant containers in cool place

Shelf Life:Powder: 2 years

Pharmacological action

Like other macrolide antibiotics, gamithromycin binds to the 50S subunit of the ribosome of sensitive bacteria, precluding peptide chain extension and affecting the conflation of bacterial proteins, thereby playing an antibacterial and bactericidal part. it substantially acts on pathogens that beget bovine respiratory conditions, similar as Mannheimia hemolytica, Pasteurella multocida, and Histophilus somnus. In addition, it has good in vitro antibacterial exertion against the pathogens of bovine contagious pleuropneumonia- Mycoplasma mycoides species, Streptococcus equi zooepidemicus, and Rhodococcus equi that are resistant and sensitive to macrolides, as well as Mycoplasma hyopneumoniae and Actinobacillus pleuropneumoniae. it has antibacterial and bactericidal goods, and has good antibacterial and bactericidal goods on the main pathogens that beget bovine respiratory conditions

Pharmacokinetics

Pharmacokinetic studies in creatures similar as cattle, lamb, gormandizers, cookers, and nags have shown that after subcutaneous or intramuscular injection, it's absorbed snappily and distributed extensively, has a special affinity for lung towel, has a bioavailability of nearly 100, maintains effective medicine attention for a long time, and is excluded sluggishly. it has a low tube protein list rate, which is 26.0, 23.1, 21.8 and 21.5 in cattle, gormandizers, rats and tykes , independently; the metabolites in different creatures are n't the same, but the metabolic pathways in rats, tykes and cattle are analogous, and the original medicine is substantially excreted through feces, followed by urine. In bovine lung epithelial cell filling fluid( PELF), bronchoalveolar lavage( BAL) cells and lung towel, the effective attention can be maintained for 7( PELF) to 15 days( BAL cells and lung towel). At 1, 5, 10 and 15 days after administration of gamithromycin, the rate of the attention in bovine lung towel to that in tube was 265, 410, 329 and 247, independently. The AUC in the lung was 194 times advanced than that in tube, and the half- life in the lung towel was as long as 90.4 h.

Preparation method

To synthesize gamithromycin using 9- deoxy- 8a- aza- 8a- homoerythromycin A as a precursor using dichloromethane as the response detergent, using bromopropane and 9- deoxy- 8a- aza- 8a- homoerythromycin A to suffer SN2 negotiation response, the final product gamithromycin can be attained, with a yield and content of 66.1 and 63.87, independently; or using the propionaldehyde cyanoborohydride sodium hydrogenation system, using 9- deoxy- 8α- aza- 8α- homoerythromycin A as an intermediate to synthesize gamithromycin, with a yield of 38.1. The high- pressure hydrogenation system was espoused, erythromycin 9,12- imidoether was used as raw material, 5 Pt/ C was used as catalyst, acetic acid was added for response, and also propionaldehyde and acetic acid were added for response to gain the target product gamithromycin, with a yield and chastity of 79.0 and 88.9, independently.

Application

It's substantially used to help and treat respiratory conditions ofnon-lactating cows caused by pathogens similar as hemolytic Mannheimia, Pasteurella and Histophilus.

1. in cattle Used to treat bovine respiratory complaint( BRD) caused by sensitive bacteria.

2. in lamb Used to control lamb bottom rot and treat lamb lameness caused by streptozotocin.

Biological activity

it is an antibacterial agent that can inhibit the growth of MmmSC strains B237 and Tan8, with MIC values of 0.00012 and 0.00006 μg/ mL, independently.

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Yihui takes pride in being a trusted Gamithromycin manufacturer and supplier. To acquire this groundbreaking product or discuss your specific requirements, contact us immediately at sales@yihuipharm.com. Rest assured, with Yihui, you're accessing a product of unparalleled quality, backed by certifications that underscore our commitment to excellence in the global market.