What is Abaloparatide powder

Abaloparatide powder is a peptide composed of 34 amino acid remainders. It's a new parathyroid hormone related peptide( PTHrP) developed by RadiosHealth. It's a important picky activator of the PTH- I receptor, which can increase bone mineral content, bone viscosity, and bone strength, promote bone conformation, and was approved by the FDA on April 28, 2017. Its trade name is Tymos. Subcutaneous injection of abapatide is used to treat osteoporosis in postmenopausal women at threat of fractures or ineffective with other treatment medicines, which can effectively reduce the prevalence of new vertebral and non vertebral fractures. Compared with tripeptide, it can more reduce the prevalence of fractures and hypercalcemia.

It's a picky activator of the parathyroid hormone receptor( PTH1 receptor), and due to its excellent osteogenic exertion, medicines made from abapatide have been promoted for clinical development for the treatment of postmenopausal osteoporosis in women with high threat of fractures.

Basic Information

Product Name: Abaloparatide

CAS: 247062-33-5

MF:C174H300N56O49

MW:3960.5896

Sequence:Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Glu-Leu-Leu-Glu-Lys-Leu-Leu-Aib-Lys-Leu-His-Thr-Ala-NH2

Purity: 99%+

Package: 1g; 5g;100g

MOQ: 1g

Origin: China

Package: 1g; 5g;10g

Used: API

Stability: Stable

Delivery Time: 3-7days

Structural formula:

Technical Specification:

Function:

(1) Promoting insulin secretion

Abaloparatide powder can stimulate pancreatic islet cells to secrete insulin, thereby lowering blood sugar levels. Additionally, it can also increase the sensitivity of insulin, Make it more effective.

( 2) Inhibiting gastric acid stashing
it can inhibit the stashing of gastric acid, thereby reducing the stimulation of the gastric mucosa by gastric acid and easing discomfort in the stomach.
3) Regulating the conflation of insulin- suchlike growth factor
it can promote the conflation of insulin- suchlike growth factor, thereby promoting cell proliferation and isolation, and playing a certain part in cell form and rejuvenescence.

Application:

The application of Abapaptide is mainly manifested in the following aspects:

(1) Lowering blood sugar levels

It can promote insulin secretion and lower blood sugar levels, which is particularly important for diabetic patients.

(2) Alleviating stomach discomfort

It can inhibit gastric acid secretion and alleviate stomach discomfort, providing some relief for symptoms such as stomach pain and indigestion.

(3) Promoting cell repair and regeneration

It can promote the synthesis of insulin-like growth factor, leading to cell proliferation and differentiation, and exerting a certain effect on cell repair and regeneration, providing some assistance in wound healing and tissue repair.

In summary, It is a very important biomolecule with multiple biological functions and pharmacological effects, playing a significant role in human health.

Preparation method

Abapa peptide is a polypeptide composed of 34 amino acid residues. The patented method of Abapa peptide is released. First, the solid -phase synthesis method is used to synthesize 3 peptide resin fragments. CHICALBOOK Section 1 is connected. However, the frozen-drying process is required before the contraction of peptide fragments 2 and 3, and the generation of peptide resin fragments 2 and 3 requires a large amount of expensive 2-CTC resin, resulting in increased production costs.

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