What is Bivalirudin Trifluoroacetate?

Bivalirudin trifluoroacetate is an engineered, direct thrombin inhibitor that is utilized in the counteraction and treatment of apoplexy. It is a powerful and specific inhibitor of thrombin, the critical catalyst in the coagulation overflow. Bivalirudin trifluoroacetate is directed intravenously and has a fast beginning of activity. It is utilized by the kidneys and has a half-existence of roughly 25 minutes.

It ties to the dynamic site of thrombin, keeping it from switching fibrinogen over completely to fibrin. This hinders the development of blood clumps. Additionally, the activation of platelets, which are responsible for the development of blood clots, is inhibited by bivalirudin trifluoroacetate.

Basic Information

Product Name: Bivalirudin Trifluoroacetate

CAS: 128270-60-0

MF:C98H138N24O33

MW:2180.29

EINECS:274-570-6

MDL No.:MFCD08282793

Purity: 98%+

Package: 1g,10g,25g,500g

Used: research and pharma grade

Stability: Stable

Structural formula:

Sequence: D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH

Store at: Cool dry place( 2-8oC, away from the light)

Specifications and Parameters:

Let's start by examining the specifications and parameters of Bivalirudin Trifluoroacetate. This information is crucial for professionals in the field to ensure accurate and effective utilization. Please refer to the table below for detailed specifications:

Chemical Composition:

Understanding the chemical composition is fundamental for professionals in the pharmaceutical and medical sectors. Refer to the table below for a breakdown of the key components:

Role and Function:

Bivalirudin trifluoroacetate is an immediate thrombin inhibitor that is utilized in the counteraction and treatment of apoplexy. It is a powerful and specific inhibitor of thrombin, the critical catalyst in the coagulation overflow. Bivalirudin trifluoroacetate ties to the dynamic site of thrombin, keeping it from changing fibrinogen over completely to fibrin. This hinders the development of blood clumps. Additionally, the activation of platelets, which are responsible for the development of blood clots, is inhibited by bivalirudin trifluoroacetate.

It is utilized in different clinical settings, including:

• Percutaneous coronary mediation (PCI): It is utilized to forestall apoplexy during PCI, a method in which a stent is set in a limited vein to further develop blood stream.

• Intense coronary condition (ACS):It is utilized to treat ACS, a condition in which there is an unexpected diminishing in blood stream to the heart.

• Affriction of the heart (AF): In patients with AF, a condition in which the heart beats irregularly, thrombosis prevention medication bivalirudin trifluoroacetate is used.

• Profound vein apoplexy (DVT): It is utilized to treat DVT, a condition in which a blood coagulation structures in a profound vein, generally in the leg.

• Aspiratory embolism (PE): PE is a condition in which a blood clot travels from a deep vein to the lungs and is treated with bivalirudin trifluoroacetate.

Synthesis Process:

The synthesis process involves several intricate steps to ensure the highest quality of Bivalirudin Trifluoroacetate. The primary components undergo controlled reactions, leading to the formation of the final product. This process involves rigorous quality control measures to meet international standards.

• Solid-phase peptide synthesis: The peptide portion of it is synthesized using solid-phase peptide synthesis (SPPS). SPPS is a method for synthesizing peptides in which the peptide is assembled on a solid support, one amino acid at a time. The amino acids are added to the solid support in the desired sequence, and each amino acid is coupled to the growing peptide chain using a coupling reagent. Once the peptide chain is complete, it is cleaved from the solid support and purified.

• Trifluoroacetylation: The peptide is then trifluoroacetylated to shape bivalirudin trifluoroacetate. Trifluoroacetylation is a cycle wherein a trifluoroacetyl bunch is added to the N-end of the peptide. This is normally done utilizing trifluoroacetic anhydride within the sight of a base.

• Purification: The product is then decontaminated utilizing various procedures, like chromatography and crystallization. This is finished to eliminate any debasements from the medication item.

• Formulation: The sanitized product is then planned into a reasonable measurements structure, like an answer for infusion. This might include adding different fixings, like cradles, additives, and stabilizers.

• The huge size of the peptide: It is a moderately enormous peptide, comprising of 20 amino acids. This makes it more challenging to integrate than more modest peptides.

• The presence of various chiral focuses: It contains numerous chiral focuses. This intends that there are numerous conceivable stereoisomers of the medication. It is vital to integrate the right stereoisomer, as the other stereoisomers might make unique or even hurtful impacts.

• The requirement for high virtue: It should be of exceptionally high virtue to be protected and compelling. This is on the grounds that even modest quantities of pollutions can fundamentally affect the medication's wellbeing and adequacy.

Product Quality Standards:

Bivalirudin trifluoroacetate is a drug item, and all things considered, it should fulfill specific quality guidelines to be protected and successful for use in patients. These quality principles are set by administrative specialists, like the US Food and Medication Organization (FDA) and the European Meds Office (EMA).

The quality principles for bivalirudin trifluoroacetate include:

• Identity: The medication should be what it is professed to be. This is regularly tried utilizing various logical strategies, like chromatography and spectroscopy.

• Purity: The medication should be liberated from debasements, like different synthetic substances, solvents, and microorganisms. This is regularly tried utilizing different scientific procedures, like chromatography and spectroscopy.

• Potency: The medication should have the normal strength or action. This is commonly tried utilizing different natural examines.

• Safety: Patients must be able to take the drug safely. This is commonly tried utilizing various creature and human examinations.

In addition to these general quality standards, bivalirudin trifluoroacetate must also meet specific quality standards for its intended use.

Yihui maintains stringent quality standards for Bivalirudin Trifluoroacetate production. The process adheres to ISO, Kosher, Halal, and GMP certifications, ensuring that the product meets the highest global benchmarks. These certifications underscore Yihui's commitment to delivering pharmaceuticals of the utmost quality.

Application Fields in Various Industries:

Bivalirudin Trifluoroacetate finds applications in diverse industries, primarily within the medical and pharmaceutical sectors. Its use in anticoagulation therapy makes it indispensable in hospitals, clinics, and other healthcare institutions. The product's versatility extends to research laboratories, contributing to advancements in cardiovascular medicine.

• Cardiology:It is utilized to forestall and treat blood clumps in patients going through percutaneous coronary mediation (PCI), like stent arrangement. It is likewise used to treat intense coronary disorder (ACS), a condition that incorporates cardiovascular failure and unsound angina.

• Neurology: It is utilized to forestall blood clumps in patients going through carotid endarterectomy, a medical procedure to eliminate plaque from the carotid course.

• Muscular medical procedure: It is utilized to forestall blood clumps in patients going through muscular medical procedure, like hip and knee substitution.

• Vascular medical procedure: It is utilized to forestall blood clusters in patients going through vascular medical procedure, for example, sidestep a medical procedure and aneurysm fix.

• Other: It is likewise used to forestall and treat blood clusters in patients with atrial fibrillation (AF), profound vein apoplexy (DVT), and pneumonic embolism (PE).

Packing & Shipping

Packing：

1kg/foil bag;5kg/carton;25kg/fiber drum; or packing as your request.

Customization:

l Customized logo

l Customized packaging

l Graphic customization

Shipping：

By Courier; By Air or By Sea, according to your demands

Payment Term

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Our Advantage

Rich experience: we have 13 Years of professional experience;

Customers all over the world: sell to more than 100 countries;

Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.

Price advance: low MOQ with competitive price;

Quality certification: ISO; Halal; Kosher certified

After-sales service: Professional team 7*24 hours customer service.

OEM Services:

Yihui offers Original Equipment Manufacturer (OEM) services, providing customized solutions to meet specific requirements. This ensures that clients receive Bivalirudin Trifluoroacetate tailored to their unique needs, further establishing Yihui as a reliable partner in the pharmaceutical industry.

Contact Us:

Yihui, a reputable manufacturer and supplier of Bivalirudin Trifluoroacetate, prioritizes product quality and conformity to international standards. With certifications such as ISO, Kosher, Halal, and GMP, Yihui stands as a testament to excellence. For those looking to purchase, contact Yihui immediately at sales@yihuipharm.com to experience the pinnacle of pharmaceutical precision.