We supply Sevelamer Carbonate API

We're pleased to offer Sevelamer Carbonate, a high- quality product aimed at meeting the requirements of the pharmaceutical assiduity. it is a phosphate binder indicated to reduce serum phosphorus in cases with habitual order complaint. Our API is of the loftiest chastity and meets all assiduity norms, icing optimal efficacity and safety in use. Our educated platoon is committed to furnishing exceptional service and support throughout the sourcing process. Trust us for a dependable, its effective force for your medicinal needs.

What's Sevelamer Carbonate?

Sevelamer Carbonate powder is a drug generally used for the treatment of cases with habitual order complaint. habitual order complaint cases frequently witness high situations of phosphate in their blood due to reduced order function, which can lead to colorful complications. it works by binding to phosphate in the gut, precluding its immersion, and lowering phosphate situations in the blood.

it is classified as a phosphate binder and is formulated as a white greasepaint, which is answerable in water. The API is an applicable lozenge form for colorful oral lozenge forms, similar as tablets, capsules, and dormancies. The API is anon-absorbable agent that remains in the gut, and thus poses little threat of toxin. Hence, it's considered safe and well- permitted by cases.

it is available in colorful strengths and can be used in combination with other specifics, similar as calcium supplements, vitamin D supplements, and other phosphate binders. It's essential to consult a healthcare professional to determine the right lozenge, as the quantum needed may vary depending on the case's medical history and current conditions.

Overall, it is an essential drug used for the treatment of habitual order complaint cases. It can help reduce the threat of complications and ameliorate the quality of life for cases. The API is safe and well- permitted, making it an ideal option for use in combination with other specifics or as a standalone drug.

Basic Information

Product Name: Sevelamer carbonate

CAS: 845273-93-0

MF:C7H14ClNO4

MW:211.64

EINECS:682-521-9

MDL No.:MFCD18904375

Structural formula:

Origin: China

Application: Hyperphosphatemia

Delivery Time: in stock

Technical Specification

Package 1kg, 25kg or according to your demands

Storage conditions: Preserve in tightly closed container between 2～8℃

Transportation conditions Transportation at room temperature

Shelf Life 24 months

Therapeutic drugs for hyperphosphatemia

Excrescence lysis pattern is the rapid-fire death of a large number of excrescence cells, the release of intracellular factors into the rotation, leading to metabolic diseases including hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia, eventually performing in acute oliguric renal failure.

The most serious consequence of hyperkalemia is fatal arrhythmia.

Hyperphosphataemia is a common metabolic complication of excrescence lysis pattern, which can reduce renal function, leading to farther reduction in the excretion of potassium and phosphate in urine.

Hypocalcemia is a consequence of hyperphosphatemia, which can beget muscle spasms, arrhythmia, and more.

Hyperphosphatemia can be treated with phosphate binders. In addition, phosphorus containing medicines should be avoided as much as possible and high phosphorus foods should be avoided.

By regulating blood phosphorus situations, hypocalcemia can self correct. When cases witness symptoms, calcium gluconate treatment should be administered.

Sevelamer Carbonate Powder is a generally used phosphate binder that detainments the immersion of phosphate from the intestine and combines with phosphate in digestive tract food to form undoable calcium phosphate, which is excreted from the body. Grown-ups are recommended to start with 800- 1600mgtid. Adverse responses include nausea, puking, constipation, diarrhea,etc.

Severam hydrochloride has no systemic immersion, so it's safe and can effectively control blood phosphorus situations without causing side goods similar as hypercalcemia. On October 30, 1998, the US Food and Drug Administration approved the product of Severam hydrochloride tablets( trade name Renagel) by two pharmaceutical companies, GenzymeGenerals and GelTex, for the treatment of hyperphosphatemia in advanced order complaint cases witnessing hemodialysis. also, the combination of Severam hydrochloride and calcitriol can be used to control parathyroid hormone situations in renal failure cases.

In clinical practice, high blood phosphorus situations may lead to fatal complications in cases witnessing hemodialysis, while Sevelamer hydrochloride can combine with normal digestive processes in the digestive tract and remove phosphorus from the diet, without causing hypercalcemia caused by conventional treatment.

Biological activity

it is a non spongy phosphate that combines withcross-linked polymers and has a analogous polymer structure to Sevelamer hydrochloride, except that carbonates replace chlorides as equilibrium ions.

In vitro research

Severamercarbonate is designed to replace Sevelamer hydrochloride and enhance buffering capacity. The Sevelamer section contains a carbon shell with polyamines, each of which is separated from the main chain by a single carbon snippet. In the intestine, Sevelamercarbonate is protonated and also binds to phosphorus tittles in the diet through the commerce of ions and hydrogen. The result of these relations is a drop in phosphorus situations in the gastrointestinal tract, leading to a drop in both salutary phosphorus immersion and serum phosphorus situations. In addition to its effect on phosphorus situations, the polyamine structure of severamer binds to corrosiveness acids to reduce total cholesterol situations.

In vivo research

In the experimental model of habitual order complaint, SeveramerCarbonate can reduce inflammation and endotoxemia caused by renal failure. In high phosphorus diet rats, it also has salutary goods on renal dysfunction, secondary hyperparathyroidism, and vascular calcification.

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Rich experience: we have 13 Years of professional experience;

Customers all over the world: sell to more than 100 countries;

Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.

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Contact Us:

Yihui takes pride in being a trusted Sevelamer Carbonate Powder manufacturer and supplier. To acquire this groundbreaking product or discuss your specific requirements, contact us immediately at sales@yihuipharm.com. Rest assured, with Yihui, you're accessing a product of unparalleled quality, backed by certifications that underscore our commitment to excellence in the global market.