Dutasteride powder

CAS No: 164656-23-9
Appearance: white or almost white crystalline powder
Standard: USP; EP
Supply Ability: 200kg per month
Purity: ≥99%
Payment: T/T, LC or DA
Delivery Time: Ready Stock in Local Warehouse, 1-3 days
Origin: China
Shipping: DHL, FedEx, TNT, EMS, By Sea, By Air
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Product Introduction

We supply Dutasteride

Our company offers high- quality Dutasteride powder for your requirements. It is a drug that's used to treat enlarged prostate in men. It works by reducing the size of the prostate gland and perfecting urinary symptoms. It is sourced from dependable suppliers and is of the loftiest norms. It's available in bulk amounts and can be used in the expression of colorful pharmaceutical products. Our platoon consists of educated professionals who insure that all products are of the loftiest quality and are delivered to you timely. communicate us moment to learn further about our Dutasteride and how it can profit you.

 

What's Dutasteride API?

Dutasteride API, also known as Avodart, is a type of drug that belongs to the 5- nascence- reductase asset class. It works by blocking the conversion of testosterone into dihydrotestosterone( DHT), which is a hormone that's responsible for the development of prostate towel. This drug is primarily used for the treatment of an enlarged prostate gland( benign prostatic hyperplasia or BPH) in men.

It is a important drug that can significantly reduce the size of the prostate gland and palliate numerous of the uncomfortable symptoms associated with an enlarged prostate, similar as difficulty urinating, frequent urges to urinate, and a weak urine sluice. It has been shown to be more effective than other specifics in its class, similar as finasteride.

It is available in oral capsule form and the lozenge depends on the specific requirements of the case. It's important to follow the instructions of a good healthcare provider when taking this drug. In addition, it may take several months before the full benefits of this drug are endured.

There are some implicit side goods associated with taking it, similar as dropped libido, erectile dysfunction, and bone tenderheartedness or blowup. These side goods are generally mild and can be managed with applicable medical treatment or by conforming the lozenge of the drug.

In summary, it is a important drug that's used to treat an enlarged prostate gland in men. It works by blocking the conversion of testosterone into DHT, which can reduce the size of the prostate gland and palliate symptoms associated with BPH. It's available in oral capsule form and can be an effective treatment option for those passing prostate- related issues. As with any drug, it's important to speak with a good healthcare provider to determine if it is the right treatment option for your unique situation.

 

Basic Information

Product Name: Dutasteride

CAS:164656-23-9

MF:C27H30F6N2O2

MW:528.53

EINECS:638-758-5

MDL No.:MFCD00937869

Melting point:

242-250°C

Structural formula:

product-1-1

Origin: China

Delivery Time: in stock

 

Technical Specification

Items

Specification

Results

Description

White or off- white powder

Off- white powder

Identification

A:Infrared absorption.

complies

B:The retention time of the major peak of the sample solution corresponds to that of the standard solution,as obtained in the assay.

 

Solubility

Soluble in dichloromethane, slightly soluble in ethyl acetate, methanol, acetronile, insoluble in water.

complies

Residue on ignition

NMT 0.1%

0.03%

Heavy Metals

Not more than 20ppm

complies

Water

NMT 0.50%

0.14%

Optical Rotation

+15.0° to +25.0°

+20.3°

Limit of platinum

NMT 5ug/g

complies

Limit of Residual Solvents

Acetonitrile NMT 0.3%

N.d

Ethyl acetate NMT 0.2%

N.d

Dioxane NMT 0.1%

N.d

n-Heptane NMT 0.5%

N.d

Organic Impurities

Procedure 1

Dutasteride acid NMT 0.2%

N.d

Dutasteride dimethylamide NMT0.2%

0.03%

Dutasteride methyl ester NMT 0.15%

0.04%

Dutasteride ethyl ester NMT 0.2%

N.d

Dutasteride 17α-5-ene NMT 0.2%

N.d

Dutasteride 17α-epimer NMT 0.3%

N.d

Chlorodutasteride NMT 0.4%

0.32%

Dutasteride -5-ene NMT 0.3%

N.d

Any other individual impurity NMT 0.1%

0.03%

Organic Impurities

Procedure 2

Dihydrodutasteride NMT 0.15%

N.d

Dutasteride α-dimer NMT 0.3%

N.d

Dutasteride β-dimer NMT 0.5%

N.d

Any other individual impurity NMT 0.1%

0.04%

Total impurities NMT 2.0%

0.33%

Assay( by HPLC)

,base on drying )

Not less than 97.0% and Not more than 102.0%

100.2%

Residual solvents

Methanol

Not more than 3000ppm

complies

Dichloromethane

Not more than 600ppm

complies

Toluene

Not more than 890ppm

complies

Chloroform

Not more than 60ppm

complies

Benzene

Not more than 2ppm

complies

Pyridine

Not more than 200ppm

complies

DMF

Not more than 880ppm

complies

Conclusion: The test product complies with our USP41.

Package: 1kg; 25kg or according to your demands

Storage: Preserve in tight containers, and store at controlled room temperature.

Shelf Life:Powder: 2 years

 

Product Usage

Dutasteride powder is a drug primarily used for the treatment of benign prostatic hyperplasia( BPH), which is an enlarged prostate gland that can beget urinary symptoms. It works by inhibiting the enzyme 5- nascence reductase, which is involved in converting testosterone to dihydrotestosterone( DHT), a hormone that contributes to prostate growth.

Then are the main uses of dutasteride

Benign Prostatic Hyperplasia( BPH): it helps to reduce the size of an enlarged prostate, which can palliate symptoms similar as difficulty urinating, frequent urination, and deficient bladder evacuating.

Hair Loss: Although not FDA- approved specifically for this use, it is occasionally specified off- marker for the treatment of manly pattern baldness( androgenetic alopecia). It's used to reduce hair loss and promote hair regrowth by dwindling DHT situations, which are associated with hair thinning.

Prostate Cancer Prevention: There's ongoing exploration into the eventuality of dutasteride to reduce the threat of prostate cancer, particularly in men who are at advanced threat. still, this use is n't as well established as its part in treating BPH.

Always use it under the guidance of a healthcare professional, as it can have side goods and relations with other specifics.

 

Medium of Action

Dutasteride is a alternate- generation α5- reductase asset approved in the United States for the treatment of benign prostatic hyperplasia. it inhibits the conversion of testosterone to dihydrotestosterone, which is an important element in the conformation and conservation of prostatic hyperplasia. During it treatment, dihydrotestosterone situations drop, but serum testosterone situations remain unchanged. Unlike α1- adrenaline receptor antagonists, which take effect incontinently, it takes several months to take effect on prostate size and symptoms of prostatic hyperplasia( reluctant and delicate urination).

 

Suggestions

Dutasteride can be used to treat moderate to severe symptoms of benign prostatic hyperplasia( BPH). It's used in cases with moderate to severe symptoms of BPH to reduce the threat of acute urinary retention( AUR) and surgery.

 

Medicine relations

Dutasteride is metabolized by CYP3A4 in the liver. In vitro tests have shown that CYP3A4 impediments similar as ritonavir, ketoconazole, verapamil, diltiazem, cimetidine and ciprofloxacin can increase the attention of dutasteride in tube, while there's no pharmacological and pharmacokinetic commerce with tamsulosin, terazosin, warfarin and cholestyramine.

 

Medicines for the treatment of benign prostatic hyperplasia

Dutasteride, a new medicine developed by GlaxoSmithKline, was approved by the US Food and Drug Administration on October 9, 2002 for the treatment of prostate blowup.

On June 19, 2008, GlaxoSmithKline blazoned that the US FDA approved its dutasteride( Avodart) in combination with tamsulosin( Harnal) for the treatment of prostate hyperplasia.

In my country, one in every two men over 60 times old suffers from benign prostatic hyperplasia, which can beget lower urinary tract symptoms, including a significant increase in urination frequence, weak urine inflow, difficulty in bladder evacuating, and nocturia, and indeed beget serious complications including acute urinary retention, which reduces the case's quality of life and affects their social life. It is the first and only binary 5α- reductase asset used to treat prostatic hyperplasia. It can ameliorate urinary system symptoms, reduce the threat of acute urinary retention and related prostate surgery. Tamsulosin is an α- receptor blocker that can ameliorate the symptoms of prostatic hyperplasia. There are two types of 5α- reductase in the mortal body, type I and type II. Type II is substantially set up in the prostate, and type I is substantially distributed in the liver and skin. 5α- reductase is an important reason for the nonstop progression of benign prostatic hyperplasia. It can promote the conversion of testosterone in the case's prostate into more active dihydrotestosterone, thereby leading to the proliferation of prostate cells and hypertrophy of the prostate. thus, the key to treating benign prostatic hyperplasia is to inhibit 5α- reductase. It can inhibit both type I and type II 5α- reductase. Through this" binary inhibition" medium, It can snappily and continuously reduce the size of the prostate, significantly ameliorate lower urinary tract symptoms, reduce acute urinary retention and related prostate surgery pitfalls, and bring lasting benefits to cases, especially those with moderate to severe benign prostatic hyperplasia.

 

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E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
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