A-443654 Supplier

Xi'an Yihui Company is a professional manufacturer of A-443654. We can generate A443654 with a 99% content. We can offer you products of the highest caliber at the most competitive rates. Your best option for a reputable pure A 443654 supplier is Xi'an Yihui Company!

What is A-443654?

A-443654( CAS 552325-16-3) is a potent and picky asset of Akt1/2/3. Akt, also known as protein kinase B( PKB), is a serine/ threonine-specific protein kinase that plays a pivotal part in colorful cellular processes including cell survival and proliferation, metabolism, and apoptosis. Aberrant Akt signaling has been intertwined in the development and progression of multiple types of cancer, and therefore Akt impediments similar as A443654 have surfaced as promising anticancer agents.

Basic Information

Product Name: A-443654

CAS: 552325-16-3

MF: C24H23N5O

MW: 397.47

MDL No.: MFCD11840663

Appearance: off white solid

Purity: 98%+

Package: 1g; 5g; 100g

MOQ: 1g

Origin: China

Used: lab research

Stability: Stable

Delivery Time: 3-7days

Structural formula:

Technical Specification:

Solubility

Insoluble in water;

DMSO ≥19.85 mg/ml;

ethanol ≥44.3 mg/ml in the ethanol

What's the function of A-443654?

A-443654 is a potent and picky asset of Akt1, Akt2 and Akt3. Akt, also known as protein kinase B( PKB), is a serine/ threonine kinase that plays a critical part in colorful cellular processes including cell growth, survival, metabolism and isolation. The dysregulation of Akt signaling pathway has been linked to colorful conditions similar as cancer, diabetes, and cardiovascular conditions.

A443654 has been considerably studied in preclinical models and has shown promising antitumor exertion in a variety of cancer cell lines and xenograft models. In addition, A443654 has been shown to acclimatize cancer cells to chemotherapy and radiation remedy, thereby enhancing the efficacity of these treatments.

piecemeal from its antitumor exertion, it has also been delved for its implicit remedial operations in cardiovascular conditions similar as atherosclerosis and ischemia- reperfusion injury. A 443654 has been shown to inhibit vascular smooth muscle cell proliferation and migration, as well as reduce neointima conformation in beast models of atherosclerosis. In addition, it has been shown to cover against myocardial ischemia- reperfusion injury by reducing infarct size and perfecting cardiac function.

Overall, it's a promising small patch asset that has implicit remedial operations in colorful conditions. farther preclinical and clinical studies are demanded to completely explore its remedial eventuality.

What's the operation of A-443654?

It's a potent asset of the Akt protein kinase, which plays an important part in interceding cell survival, proliferation, and metabolism. Akt activation is constantly observed in a variety of mortal cancers, making it an seductive remedial target for cancer treatment.

Its operation is primarily in cancer exploration, where it has been shown to inhibit the growth and proliferation of colorful cancer cell lines in vitro and in vivo. Studies have also demonstrated that it can acclimatize cancer cells to chemotherapy and radiation remedy, which may enhance the efficacity of these treatments.

In addition to itsanti-cancer parcels, it has also been studied for its eventuality in treating diabetes and metabolic diseases. Akt is a crucial controller of glucose metabolism, and inhibition of Akt exertion has been shown to ameliorate insulin perceptivity, glucose uptake, and lipid metabolism. Beast studies have shown that it can significantly ameliorate glucose forbearance and pancreatic beta- cell function in diabetic mice, making it a promising remedial agent for diabetes treatment.

Overall, it's a protean emulsion with implicit operations in cancer exploration as well as in the treatment of metabolic diseases. Its capability to widely inhibit Akt exertion makes it a precious tool for studying the part of Akt in colorful cellular processes, and its remedial eventuality makes it a promising seeker for unborn medicine development.

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Yihui takes pride in being a trusted A-443654 manufacturer and supplier. To acquire this groundbreaking product or discuss your specific requirements, contact us immediately at sales@yihuipharm.com. Rest assured, with Yihui, you're accessing a product of unparalleled quality, backed by certifications that underscore our commitment to excellence in the global market.