What is AZD5363?

Azd5363, a cutting-edge product in the pharmaceutical and research industry, is a highly specialized compound known for its diverse applications and remarkable efficacy. Developed by Yihui, a reputable manufacturer and supplier in the field, Azd5363 has garnered significant attention for its exceptional quality and performance.

Azd5363 is a novel, orally bioavailable inhibitor of BTK with likely restorative applications in various B cell malignancies and immune system illnesses. The medication is for the most part very much endured and has a good wellbeing profile. It is presently in late-stage clinical turn of events, and it is normal to be supported for advertising soon.

Basic Information

Product Name: AZD5363

CAS: 1143532-39-1

MF:C21H25ClN6O2

MW:428.92

MDL No.:MFCD22628785

Purity:  99%

Package: 1g; 5g; 25g; 1kg

Used: pharma grade & Lab research

Stability: Stable

Structural formula:

Specification Parameter:

Chemical Composition:

Role and Function Description:

Azd5363 plays a pivotal role in inhibiting specific kinases, disrupting key signaling pathways that are implicated in various diseases, including certain cancers. Its ability to selectively target and modulate these pathways makes it an indispensable tool for researchers and clinicians alike.

In cancer research, Azd5363 has demonstrated promising results by impeding the growth of tumor cells and suppressing metastasis. Additionally, its application extends to neurodegenerative disorders, where it shows potential in mitigating pathological processes. The compound's versatility is further underscored in inflammation studies, showcasing its anti-inflammatory properties.

It is a Bruton's tyrosine kinase (BTK) inhibitor. BTK is a key flagging particle in B cells and macrophages, and its restraint has been displayed to have remedial likely in different B cell malignancies and immune system illnesses. It ties to the ATP-restricting pocket of BTK, in this way repressing its enzymatic action. This prompts the restraint of downstream flagging pathways, including the PI3K/Akt/mTOR and NF-κB pathways, which are engaged with cell development, endurance, and separation.

It is a novel, orally bioavailable inhibitor of BTK with possible restorative applications in various B cell malignancies and immune system illnesses. The medication is for the most part very much endured and has a good wellbeing profile.It is presently in late-stage clinical turn of events, and it is normal to be supported for advertising soon.

Synthesis Process Description :

The synthesis of Azd5363 is a complex multi-step process that involves several key reactions. A general overview of the synthesis process is as follows:

1. Starting Materials: The synthesis of Azd5363 begins with the preparation of two key starting materials: 4-amino-3-(4-fluorophenyl)benzoic acid and 2-amino-4-methylpyrimidine.

2. Suzuki Coupling: The first step in the synthesis is a Suzuki coupling reaction between 4-amino-3-(4-fluorophenyl)benzoic acid and 2-amino-4-methylpyrimidine. This reaction is catalyzed by a palladium catalyst and forms a biaryl intermediate.

3. Alkylation: The biaryl intermediate is then alkylated with 1-bromo-3-chloropropane to form an alkylated intermediate.

4. Cyclization: The alkylated intermediate is then cyclized to form a pyrimidine ring. This cyclization reaction is typically carried out using a strong base, such as sodium hydride.

5. Acylation: The pyrimidine ring is then acylated with 4-methylbenzoyl chloride to form an acylated intermediate.

6. Suzuki Coupling: The acylated intermediate is then subjected to a second Suzuki coupling reaction, this time with 4-methoxyphenylboronic acid. This reaction forms the final biaryl intermediate.

7. Final Cyclization: The final biaryl intermediate is then cyclized to form the desired product, Azd5363. This cyclization reaction is typically carried out using a strong base, such as sodium hydride.

The synthesis of Azd5363 involves a meticulous process that ensures the purity and efficacy of the final product. Starting with high-quality raw materials, Yihui employs state-of-the-art synthesis techniques, carefully controlling reaction parameters to achieve optimal results. The process involves multiple purification steps to eliminate impurities, guaranteeing a product of the highest pharmaceutical grade.

Quality Standard Description :

Azd5363's quality standards include the following aspects:

1. Appearance: It should be a white to off-white powder or crystals.

2. Solubility: It should be soluble in dimethyl sulfoxide (DMSO) and ethanol.

3. Content: The content of products should be between 98.0% and 102.0%.

4. Impurities: The impurity content in the products should be less than 0.5%.

5. Moisture: The moisture content in it should be less than 0.5%.

6. Heavy metals: The heavy metal content in Azd5363 should comply with the requirements of the ICH Q3D guideline.

7. Microorganisms: The microbial content in Azd5363 should comply with the requirements of USP<61> and <62>.

8. Accelerated stability testing: It is stored at 40℃/75%RH for 6 months.

9. Long-term stability testing: It is stored at 25℃/60%RH for 24 months.

The results of the stability testing should demonstrate that Capivasertib is stable under the storage conditions.

At Yihui, quality is paramount. Our production facilities adhere to stringent international standards, and our Azd5363 undergoes rigorous testing at every stage of production. With a commitment to excellence, Yihui has obtained ISO, Kosher, Halal, and GMP certifications, attesting to the product's compliance with the highest industry standards. Our quality assurance measures ensure that each batch of Azd5363 meets the specified purity and performance criteria.

Application Fields in Various Industries :

Azd5363 is a promising new treatment for different B cell malignancies and immune system illnesses. It is a very much endured drug with a positive wellbeing profile. Clinical preliminaries have shown that it is compelling in treating these circumstances, and turning into a significant treatment choice for patients with these diseases is normal.

It is a medicine that is used to treat a variety of autoimmune conditions and cancers caused by B cells. It is a Bruton's tyrosine kinase (BTK) inhibitor, and that implies that it obstructs the action of BTK, a protein that is engaged with the flagging pathways of B cells.

Capivasertib finds applications across diverse industries, ranging from pharmaceuticals to academic research. In the pharmaceutical sector, it serves as a key component in the development of novel therapeutics for cancer and other diseases. Researchers in academia leverage its kinase inhibitory properties for elucidating intricate cellular signaling pathways, contributing to advancements in molecular biology.

Packing & Shipping

Packing：

1kg/foil bag;5kg/carton;25kg/fiber drum; or packing as your request.

Customization:

l Customized logo

l Customized packaging

l Graphic customization

Shipping：

By Courier; By Air or By Sea, according to your demands

Payment Term

Why Choose Xi'an Yihui?

Customer feedback

Xi'an Yihui certificates

Welcome to Xi'an Yihui Factory  

Our Advantage

Rich experience: we have 13 Years of professional experience;

Customers all over the world: sell to more than 100 countries;

Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.

Price advance: low MOQ with competitive price;

Quality certification: ISO; Halal; Kosher certified

After-sales service: Professional team 7*24 hours customer service.

Contact Us:

Yihui, as a professional Azd5363 manufacturer and supplier, is dedicated to upholding the highest standards in the industry. Our adherence to international certifications such as ISO, Kosher, Halal, and GMP reflects our commitment to product quality and customer satisfaction. For inquiries or purchases, please contact us immediately at sales@yihuipharm.com.