What is ABT-199

ABT-199 also is known as GDC-0199 and Venetoclax . it is a new type of anti-cancer drug, belonging to the Bcl-2 inhibitor, developed by American pharmaceutical company AbbVie. It can effectively resist cancer and has fewer side effects compared to current drugs. This study was mainly completed by researchers in the United States and Australia. the related research results are published in the international journal "NatureMedicine". Unlike regular cancer drugs, Chemicalbook: This drug, named ABT-199, works by attacking an important protein called BCL-2 to treat cancer. BCL-2 is one of the earliest discovered members of the BCL-2 protein family that regulates cell death. It is associated with many types of cancer, such as some mental and autoimmune diseases. In cancer, it is believed to act as an inhibitor that can help cancer cells resist cancer treatment drugs.

ABT-199 (Venetoclax) is a novel drug that works to treat cancer by attacking an important protein called BCL-2. BCL-2 is one of the earliest discovered members of the BCL-2 protein family that regulates cell death. In cancer, it is believed to act as an inhibitor that can help cancer cells resist cancer treatment drugs.

Basic Information

Product Name: ABT-199; Venetoclax; GDC-0199

Cas No.: 1257044-40-8

MF: C45H50ClN7O7S

MW: 868.44

EINECS: 820-130-9

MDL No.:MFCD23160052

Appearance: yellow solid

Purity: 99%+

Package: 1g; 5g; 100g

MOQ: 1g

Origin: China

Used: lab research

Stability: Stable

Delivery Time: 3-7days

Structural formula:

Technical Specification:

Biological activity

ABT-199 (GDC-0199) is a selective inhibitor of Bcl-2, with a Ki value of<0.01 nM in cell-free assays, which is more than 4800 times more selective than Bcl-xL and Bcl-w. It has no inhibitory activity against Mcl-1.

What is the function of ABT-199?

Venetoclax is used for the treatment of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). ABT-199 works by blocking B-cell lymphoma-2 (BCL-2), a protein that helps cancer cells survive.

it is specifically indicated for the treatment of CLL that has relapsed or did not adequately respond to other chemotherapy treatment options. Additionally, this medication is recommended for newly diagnosed CLL patients with particular genetic abnormalities that make them susceptible to GDC-0199 treatment. For AML, it is given in combination with other chemotherapy drugs for the treatment of patients 75 years of age and older, or who cannot tolerate standard chemotherapy treatment due to comorbidities.

It is typically administered orally once daily at a medical facility or home, with monitoring for any potential side effects. Although it has been shown to be an effective treatment for CLL and AML, an individual's response to it can vary and may require dose adjustments.

Overall, it is an important medication for the treatment of CLL and AML, improving patient outcomes and providing hope for those diagnosed with these conditions.

What is the Application of ABT-199?

Venetoclax is a targeted therapy medication used in the treatment of chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). This medication is specifically designed to target the B-cell lymphoma 2 (BCL-2) protein, which typically promotes the survival of cancer cells and prevents them from dying off naturally.

By inhibiting BCL-2, it triggers a process called apoptosis, which is the programmed death of cancer cells. This ultimately leads to the reduction of cancerous cells and can slow or even halt the progression of CLL and SLL.

In addition to its use in CLL and SLL, it has also shown promising results in the treatment of other types of cancer, including acute myeloid leukemia (AML), diffuse large B-cell lymphoma (DLBCL), and multiple myeloma.

it is an oral medication that is typically taken once daily. It is generally well-tolerated, but some patients may experience side effects such as nausea, diarrhea, fatigue, and low white blood cell count.

Overall, it may provide a targeted, effective treatment option for those with CLL, SLL, and other cancers. Consultation with a healthcare provider is necessary to determine if this medication is appropriate for individual patients.

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