What is Gsk126?

Gsk126 is a novel, specific inhibitor of glycogen synthase kinase-3 (GSK-3) that has shown promising helpful possible in different preclinical models of illness. GSK-3 is a serine/threonine kinase that assumes a basic part in the guideline of glycogen digestion, cell development and separation, and apoptosis. Dysregulation of GSK-3 action has been ensnared in the pathogenesis of a few illnesses, including type 2 diabetes, Alzheimer's sickness, and disease.

It prevents the transfer of phosphate from ATP to serine or threonine residues on target proteins by binding to the enzyme's ATP-binding pocket. This hindrance brings about the initiation of downstream flagging pathways that advance cell endurance, development, and separation.

In preclinical examinations, Gsk126 has shown viability in different models of illness. For instance, in creature models of type 2 diabetes, it further developed insulin responsiveness and glucose resilience. In models of Alzheimer's sickness which decreased amyloid-beta plaque arrangement and worked on mental capability. In disease models, it restrained cancer development and metastasis.

It is as of now being assessed in clinical preliminaries for the therapy of a few sicknesses, including type 2 diabetes, Alzheimer's illness, and malignant growth. Progressively work 2 preliminaries in patients with type 2 diabetes have shown that Gsk126 is protected and all around endured and that it can further develop insulin awareness and glucose control. Gradually work 2 preliminaries in patients with Alzheimer's sickness have likewise shown that it is protected and very much endured and that it can work on mental capability. Work 3 preliminaries in patients with type 2 diabetes and Alzheimer's sickness are right now continuous.

Basic Information

Product Name: GSK126

CAS: 1346574-57-9

MF:C31H38N6O2

MW:526.67

form Solid

color Off-White

Purity: 98%+

Package: 1g; 5g; 25g

Used: Lab research

Stability: Stable

Structural formula:

Specifications and Parameters：

Let's delve into the technical aspects of Gsk126 through a detailed specifications and parameters table:

Chemical Composition：

Gsk126's chemical composition is a carefully balanced blend designed to ensure optimal performance. Here's a breakdown:

Role and Function ：

Gsk126 is a novel, specific inhibitor of glycogen synthase kinase-3 (GSK-3) that has shown promising helpful possible in different preclinical models of illness. GSK-3 is a serine/threonine kinase that assumes a basic part in the guideline of glycogen digestion, cell development and separation, and apoptosis. Dysregulation of GSK-3 action has been ensnared in the pathogenesis of a few illnesses, including type 2 diabetes, Alzheimer's sickness, and disease.

It is a vital controller of glycogen digestion. It phosphorylates and inactivates glycogen synthase, the protein answerable for the union of glycogen. This restraint of glycogen synthase brings about the breakdown of glycogen and the arrival of glucose into the circulation system. Gsk126 hinders GSK-3, accordingly forestalling the phosphorylation and inactivation of glycogen synthase. This outcomes in expanded glycogen combination and diminished glucose discharge into the circulation system.

It likewise assumes a part in the guideline of cell development and separation. It phosphorylates and initiates cyclin D1, a protein that is fundamental for cell cycle movement. Gsk126 represses GSK-3, accordingly forestalling the phosphorylation and initiation of cyclin D1. This outcomes in the restraint of cell cycle movement and the advancement of cell separation.

Dysregulation of GSK-3 action has been embroiled in the pathogenesis of a few illnesses, including type 2 diabetes, Alzheimer's sickness, and disease. In type 2 diabetes, GSK-3 is overactive, which prompts expanded glycogen breakdown and glucose discharge into the circulatory system. This can prompt insulin opposition and hyperglycemia. In Alzheimer's illness, It is additionally overactive, which prompts the development of amyloid-beta plaques and neurofibrillary tangles, two of the signs of the sickness. GSK-3 is often overactive in cancer, which can cause more cell growth and proliferation and less apoptosis.

Synthesis Process：

Gsk126 is a synthetic compound that is not found naturally. It is synthesized in a multi-step process that typically begins with the reaction of 4-chloro-3-fluorobenzaldehyde with 2-bromo-4'-methoxyacetophenone to form an intermediate compound. This intermediate is then reacted with 3-aminopyridine to form another intermediate compound. This intermediate is then reacted with 4-fluorobenzoyl chloride to form the final product, Gsk126.

The synthesis of Gsk126 is a complex process that requires specialized equipment and expertise. It is typically carried out by pharmaceutical companies or contract research organizations.

• Step 1: Reaction of 4-chloro-3-fluorobenzaldehyde with 2-bromo-4'-methoxyacetophenone to form an intermediate compound.

• Step 2: Reaction of the intermediate compound from Step 1 with 3-aminopyridine to form another intermediate compound.

• Step 3: Reaction of the intermediate compound from Step 2 with 4-fluorobenzoyl chloride to form the final product, Gsk126.

Once the synthesis of Gsk126 is complete, the product must be purified to remove any impurities. This is typically done using a variety of techniques, such as recrystallization, chromatography, and filtration. The purified product is then subjected to rigorous quality control testing to ensure that it meets the required standards for safety and efficacy.

The synthesis of it is a complex process that requires specialized equipment and expertise. It is typically carried out by pharmaceutical companies or contract research organizations. The key steps in the synthesis process involve the reaction of 4-chloro-3-fluorobenzaldehyde with 2-bromo-4'-methoxyacetophenone, followed by the reaction of the intermediate compound with 3-aminopyridine and then 4-fluorobenzoyl chloride. Once the synthesis is complete, the product must be purified and subjected to quality control testing before it can be used for clinical trials or commercial production.

Product Quality Standards :

Quality is non-negotiable at Yihui, and it is no exception. Produced in strict accordance with international standards, our manufacturing processes adhere to ISO, Kosher, Halal, and GMP certifications. Rigorous quality control measures are implemented at every stage, ensuring that each batch of Gsk126 meets the highest standards of purity, efficacy, and safety.

• Identity: The item should be precisely recognized and match the determinations for Gsk126.

• Purity: The item should be liberated from contaminations, for example, different synthetic compounds or solvents that might have been utilized in the assembling system.

• Potency: The item should contain the right measure of Gsk126 and meet the named power particulars.

• Safety: The product must not contain any harmful contaminants and must be safe for human use.

• Efficacy: The item should be powerful in treating the planned illness or condition.

Application Fields in Various Industries:

Gsk126 finds applications across diverse industries, showcasing its versatility. In the pharmaceutical sector, it serves as a crucial component in drug development, particularly in the field of cancer research. Its epigenetic modulation capabilities open doors to innovative therapeutic approaches.

• Diabetes: It is being looked into as a way to treat type 2 diabetes. It is remembered to work by further developing insulin responsiveness and glucose control.

• Alzheimer's sickness: It is likewise being concentrated as a possible treatment for Alzheimer's infection. It is remembered to work by hindering the development of amyloid plaques, which are a sign of the infection.

• Cancer: It is being looked at as a treatment option for leukemia, lymphoma, and colon cancer, among other types of cancer. It is remembered to work by restraining cell development and multiplication.

• Anti-aging: It has been displayed to hinder the development of melanin, which is liable for skin pigmentation. This proposes that it might have expected applications in enemy of maturing beauty care products.

• Skin easing up: It could also be useful in products that lighten the skin. By hindering melanin creation, it could assist with lessening the presence of dim spots and hyperpigmentation.

• Crop insurance: It has been displayed to hinder the development of specific growths and microorganisms that can harm crops. This recommends that it might have likely applications in crop security.

• Biotechnology: It is a useful instrument for investigating the function that GSK-3 plays in various biological processes. It is used to study cell signaling, metabolism, and disease in laboratories all over the world.

• Drug development: It is additionally utilized in drug disclosure endeavors to recognize better than ever medicines for different illnesses

In the field of regenerative medicine, Gsk126's potential in influencing stem cell differentiation has garnered attention. This positions it as a key player in the pursuit of novel treatments for degenerative diseases.

Packing & Shipping

Packing：

1kg/foil bag;5kg/carton;25kg/fiber drum; or packing as your request.

Customization:

l Customized logo

l Customized packaging

l Graphic customization

Shipping：

By Courier; By Air or By Sea, according to your demands

Payment Term

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Yihui takes pride in being a trusted Gsk126 manufacturer and supplier. To acquire this groundbreaking product or discuss your specific requirements, contact us immediately at sales@yihuipharm.com. Rest assured, with Yihui, you're accessing a product of unparalleled quality, backed by certifications that underscore our commitment to excellence in the global market.