We supply Zolmitriptan API

Welcome to our company!We specialize in furnishing high- quality Zolmitriptan API for the pharmaceutical assiduity. it is a picky serotonin receptor agonist, and it's used to treat migraines with or without air in grown-ups. Our product is produced with top- notch technology and strict quality control measures to insure safe and effective results. We also offer excellent client service and competitive pricing. Whether you're a small business proprietor or a large pharmaceutical company, we're confident that our Zolmitriptan will meet your requirements. communicate us moment to learn more!

What's Zolmitriptan ?

it is an organic emulsion with the chemical formula C16H21N3O2. It's a picky 5- hydroxytryptamine( 5- TH1B and 5- TH1D) receptor agonist that relieves migraine attacks by cranking intracranial blood vessels( including arteriovenous anastomosis) and 5- HTIB/ ID receptors on the sympathetic jitters of the trigeminal nervous system, constricting blood vessels, and inhibiting the release of neuropeptides.

it also known as( S)-4-( 3-( 2-( dimethylamino) ethyl)-1 H- indolo-5-yl) methyl)-2-oxazolidinone, is an anti migraine medicine developed by Glaxo Wellcome, Germany. It's a largely picky 5- HT1B/ 1D receptor agonist. It was first launched in the UK in 1997 and was approved for trade by the US Food and Drug Administration( FDA) in 1998. Clinically used for acute treatment of migraines with or without monitory symptoms.

Basic Information

Product Name: Zolmitriptan

CAS: 139264-17-8

MF:C16H21N3O2

MW:287.36

EINECS:629-919-0

MDL No.:MFCD00871503

Structural formula:

Origin: China

Application: Anti-Migraine

Delivery Time: in stock

Technical Specification

Package: 100g; 500g; 1kg or according to your demands

Storage: Preserve in tight,light-resistant containers in a cool place

Shelf Life: 24 months

Mechanism of action

Zolmitriptan API is an effective and specific medicine for the treatment of acute migraine, which induces vasoconstriction by cranking the 5- HT1 receptor and inhibits the release of neuropeptides, thereby easing the onset of migraine. The exploration results indicate that it can control supplemental blood inflow in the brain and also act on the pain center of the brain, thereby playing a part in treating migraines. When stimulating the trigeminal whim-whams or passing migraine attacks, cerebral blood inflow increases, calcitonin gene related peptide( CGRP) is released, and CGRP and vasoactive peptide( personality) in the external jugular tone increase. Zometreptan can access the blood- brain hedge and has a binary effect on the central and supplemental jitters. It can widely contract intracranial blood vessels, especially cranial highways, and control supplemental blood inflow in the brain. It can also inhibit the release of vasoactive substances similar as CGRP, neurotransmitters A and P, causing vasoconstriction of the dural roadway and reducing aseptic inflammation. Research has shown that it has an inhibitory effect on HVACa2 ion channels, thereby reducing the release of neurotransmitters( similar as CGRP) and playing a remedial part in migraines.

Application

it is an effective traptan medicine used to treat acute migraine attacks with or without air. As a picky serotonin receptor agonist, it specifically targets the 5- HT1B and 5- HT1D receptors set up in the brain. By doing so, it helps to reduce inflammation and pain associated with migraines.

The API interpretation of zolmitrazan is an ideal result for pharmaceutical companies to develop and produce effective migraine treatment styles. This pure form of medicine can be fluently incorporated into colorful lozenge forms, including tablets, capsules, and injections. Its high efficacity allows for the use of small boluses, making it an profitable choice for manufacturers.

The Zuomitratan API is also a precious tool for experimenters to study the pathogenesis of migraines. The capability to use pure, separated medicine forms provides lesser control over the trial, performing in more accurate and meaningful results. This in turn can give a better understanding of the root causes and implicit treatment options for migraines.

In addition to its remedial benefits, API zolmitrazan is also known for its low toxin. It has been considerably studied and proven to be largely safe, making it suitable for a wide range of cases. This safety also applies to pregnant and lactating women, making it a useful choice for treating migraines in this population.

Overall, API zolmitrazan is a multifunctional and effective treatment option for migraine cases. Its ease of use and low toxin make it an ideal choice for the pharmaceutical assiduity, and its remedial benefits make it an important tool for experimenters to more understand this enervating condition.

Synthetic method

it was synthesized from( L)- phenylalanine by nitration, esterification, reduction( ester group), cyclization, reduction( nitro group), diazotization, and reduction( diazonium swab).

The below illustration shows its synthetic route

Adverse reactions

This product has good forbearance. The adverse responses are mild or mild, brief, and can self palliate without treatment. Possible adverse responses frequently do within 4 hours after drug, and there's no increase in continued use. The most common adverse responses include occasional nausea, dizziness, doziness, warmth, weakness, and dry mouth. sensitive abnormalities or sensitive diseases have been reported. The throat, neck, branches, and casket may witness heaviness, miserliness, and contraction( there is no substantiation of ischemic changes on the electrocardiogram), as well as muscle pain and weakness.

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In summary, as a professional Zolmitriptan APImanufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make it stand out in the market competition and win more customer trust and support. if you need it, pls feel free to contact us any time. we will reply you asap.

our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937