We supply Sildenafil Citrate

We offer high- quality Sildenafil Citrate API for pharmaceutical manufacturers. it is a extensively used drug for the treatment of erectile dysfunction, pulmonary arterial hypertension, and other affiliated conditions. Our Sildenafil Citrate is produced to meet strict quality norms, icing its safety and efficacity. We use advanced manufacturing ways and state- of- the- art outfit to produce our API, icing thickness in chastity, strength, and quality. Our products are available at competitive prices and can be customized to meet your specific requirements. Trust us to give you with dependable and harmonious Sildenafil Citrate for your medicinal manufacturing requirements.

What's Sildenafil Citrate?

Sildenafil Citrate is a drug that's used to treat erectile dysfunction( ED) in men. Also known as a phosphodiesterase type 5( PDE5) asset, this drug helps to ameliorate blood inflow to the penis, allowing for a stronger and longer- lasting construction.

it works by blocking the action of an enzyme known as PDE5. When this enzyme is blocked, it allows for the smooth muscle cells in the penis to relax, allowing blood to inflow more fluently into the penis. This, in turn, results in an bettered capability to achieve and maintain an construction during sexual exertion.

it is available in tablet form, and is generally taken orally about an hour before sexual exertion. The drug can be taken with or without food, but it's recommended to avoid consuming high-fat refections as this can delay the onset of the drug's goods.

It's important to note that it is n't a cure for erectile dysfunction, but rather a treatment option that can help to palliate symptoms. It's also not recommended to take Sildenafil Citrate further than formerly per day, as this can increase the threat of passing negative side goods.

Common side goods associated with Sildenafil Citrate include headache, flushing, indigestion, and nasal traffic. More serious side goods, while rare, can include unforeseen hail loss or vision loss.However, it's important to seek medical attention incontinently, If you witness any of these symptoms while taking Sildenafil Citrate.

Overall, it is a safe and effective drug that can help to ameliorate sexual performance for men with erectile dysfunction. It's important to consult with a healthcare provider to determine if this drug is right for you, and to insure that you're taking it safely and meetly.

Basic Information

Product Name: Sildenafil citrate

CAS: 171599-83-0

MF:C28H38N6O11S

MW:666.7

EINECS:200-659-6

MDL No.:MFCD02102122

Melting point:187-189°C

Structural formula:

Origin: China

Delivery Time: in stock

Technical Specification

Package: 1kg; 25kg or according to your demands

Storage: Preserve in tight,light-resistant containers in cool place

Shelf Life: 2 years

Pharmacological action

Sildenafil citrate API is a picky 5- phosphodiesterase asset. It inhibits the corruption of cyclic guanosine monophosphate and enhances nitric oxide-dependent, cyclic guanosine monophosphate- intermediated pulmonary vasodilation. In addition to directly dilating pulmonary vasodilation, it can also help or reverse vascular redoing.

Medicinal properties and applications

Sildenafil citrate is vended under the trade name of Viagra, generally known as Viagra. It's a cyclic guanosine monophosphate( cGMP)-specific 5- type phosphodiesterase( PDE5) asset that can enhance construction after oral administration. It can enhance the effect of nitric oxide( NO) by inhibiting the 5- type phosphodiesterase that decomposes cyclic guanosine monophosphate( cGMP) in the corpus cavernosum of the penis. When sexual stimulation factors beget original NO release, it increases the position of cGMP in the corpus cavernosum, relaxes the smooth muscles in the corpus cavernosum, increases blood flux, prolongs the duration of penile construction, and increases the firmness. It's used for cases with erectile dysfunction. Grown-ups take 50 mg orally each time, up to formerly a day, and use as demanded about 1 hour before sexual intercourse. The maximum cure is 0.1 g each time.

Biological activity

Sildenafil Citrate, a cGMP-specific VI- type phosphodiesterase( PDE5) picky asset, has good tolerability and high efficacity for erectile dysfunction.

Target

In vitro studies

Sildenafil citrate is a potent, reversible, picky asset of PDE V, which can effectively block the hydrolysis of cGMP( Ki~ 3 nM). Sildenafil shows high affinity for PDE V and VI, with inhibition constants( Ki) of ~3.5 and 33 nM, independently. In an organ bath, Sildenafil enhances the relaxation ofpre-contracted corpus cavernosum smooth muscle convinced by sodium nitroprusside or transmural electrical stimulation, indicating that sildenafil enhances NO- mediated relaxation exertion. Sildenafilcitrate increases intracellular cGMP attention in dressed sodium nitroprusside- treated smooth muscle cells and in vitro rabbit corpus cavernosum. Sildenafil is metabolized in the liver by cytochrome P450 to an active metabolite with parcels analogous to the parent emulsion.

In vivo studies

In anesthetized dogs, Sildenafil citrate enhances penile erectile function in response to pelvic nerve stimulation, as measured by intracavernosal pressure. Sildenafil citrate significantly reverses impaired carbachol-stimulated relaxation and inhibits superoxide formation in corpus cavernosum tissue of hypercholesterolemic rabbits. In Sprague-Dawley rats, Sildenafil improves erectile function in a time- and dose-dependent manner, with maximum recovery of erectile function occurring on day 28 at a dose of 20 mg/kg per day. In Sprague-Dawley rats, Sildenafil administration results in protection of smooth muscle collagen ratio and preservation of CD31 and eNOS expression. In Sprague-Dawley rats, Sildenafil significantly reduced the apoptotic index and increased the phosphorylation of akt and eNOS compared with the control group.

Packing & Shipping

Packing：

1kg/foil bag;5kg/carton;25kg/fiber drum; or packing as your request.

Customization:

l Customized logo

l Customized packaging

l Graphic customization

Shipping：

By Courier; By Air or By Sea, according to your demands

Payment Term

Why Choose Xi'an Yihui?

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as a professional Sildenafil Citrate API manufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make it stand out in the market competition and win more customer trust and support. if you need it, pls feel free to contact us any time. we will reply you asap.

our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937