We supply Adapalene powder

We're pleased to offer Adapalene powder for your specific requirements. Our high- quality product is a outgrowth of vitamin A and is generally used to treat acne as well as other skin conditions. it is produced with the utmost care and meets strict quality norms, icing that you admit a dependable and effective product. Whether you're a experimenter or manufacturer, it can be an essential component for your laboratory or manufacturing process. witness the benefits of our top- grade Adapalene  moment!

What's Adapalene API?

Adapalene API, also known as 6-( 3-( 1- adamantyl-4-methoxyphenyl)-2-naphthoic acid, has the molecular formula C28H28O3. It appears as a white or nearly white powder at room temperature, undoable in water or ethanol, and slightly answerable in tetrahydrofuran. it is a dermatological drug that's clinically suitable for the treatment of acne vulgaris characterized by acne, pustules, and papules. It can also be used to treat acne on the face, casket, and back.

it is a new naphthoic acid secondary medicine developed by GaldamaLaboratories in France. It was first launched in June 1996 in France under the trade name" Differin" and is substantially used to ameliorate seditious skin lesions, regulate the isolation of hair follicles and sebaceous gland epithelial cells, and treat acne.

Basic Information

Product Name: Adapalene

CAS: 106685-40-9

MF:C28H28O3

MW:412.52

EINECS:620-513-9

MDL No.:MFCD03106112

Melting point:319-3220C

Boiling point:606.3±55.0 °C(Predicted)

Density 1.233±0.06 g/cm3(Predicted)

Structural formula:

Application: Skin Care

Origin: China

Delivery Time: in stock

Technical Specification

Package: 100g;1kg;25kg; or according to your demands

Storage conditions:2-8℃, protected from light and moisture, sealed and dry

Transportation conditions: 2-8 ℃ transportation

Shelf Life:24 months

Application

Adapalene API is a topical drug primarily used in the treatment of acne. It belongs to the class of medicines known as retinoids. it works by binding to specific retinoic acid receptors in the skin, which in turn affects the growth and isolation of skin cells.

One of its main advantages over other topical retinoids is that it has a fairly low eventuality for vexation. This makes it well- suited for use in cases with sensitive or dry skin. it is available in the form of a gel or cream and is generally applied formerly per day.

it has a number of different operations beyond acne treatment. It has been studied for use in the treatment of photoaging, wrinkles, and other signs of skin aging. There's also some substantiation to suggest that it may be effective in the treatment of psoriasis and other seditious skin conditions.

Some implicit side effects include blankness, greenishness, and scaling. These side goods tend to be mild and generally resolve on their own over time. it should be used with caution during gestation as it may be teratogenic.

Overall, it is a protean and effective topical drug used in the treatment of acne and other skin conditions. Its low eventuality for vexation and other favorable side effect profile make it a popular choice among cases and healthcare professionals likewise.

Pharmacological action

Adapalene powder is a retinoic acid emulsion that has been shown to haveanti-inflammatory parcels in in vivo and in vitro inflammation models. It has a stable chemical structure and isn't fluently perished

in air and light. The medium of action is the same as that of retinoic acid, which can bind to specific retinoic acid nuclear receptors, but the difference is that adapalene doesn't bind to protein- bound cytoplasmic receptors. In the skin medicine test conducted in the beast model established by mice, it was proved that it can treat acne and also has an effect on common acne and isolation process. The medium of action is to reduce the conformation of microacne by normal isolation of hair cells on hair follicles. In the standardanti-inflammatory analysis in vivo and in vitro, it is more effective than retinoic acid. It can inhibit the chemotactic response of mortal polymorphonuclear leukocytes, and inhibit the metabolism of polymorphonuclear cells by inhibiting the conversion of arachidonic acid into seditious intercessors through lipid oxidation, thereby easing the seditious response intermediated by cell response. It's suitable for the treatment of common skin acne with acne, pustules and papules as the main instantiations. It can also be used to treat acne on the face, casket and back.

Pharmacokinetics

The transdermal immersion rate of adapalene is veritably low; in clinical trials, the attention of adapalene in skin with large areas of acne was too low to be detected later long- term use. 14C- labeled adapalene was administered to rats( intravenous injection, intraperitoneal injection, oral administration and skin administration) and rabbits( intravenous injection, oral administration and skin administration), and radioactivity was distributed in numerous apkins, with the loftiest situations in the liver, spleen, adrenal glands and ovaries. it is metabolized in creatures substantially through oxygen- demethylation, hydroxylation and conjugation responses. It's substantially excreted through corrosiveness.

Interactions

No relations have been set up between this product and other medicines that may be used on the skin at the same time. still, other retinoids or other medicines with analogous mechanisms of action shouldn't be used at the same time. The chemical structure of adapalene is stable and isn't fluently perished

in air and sun. expansive beast and mortal studies haven't set up phototoxicity and photosensitivity. still, the safety of adapalene in creatures and humans when constantly exposed to sun or ultraviolet radiation isn't yet known. When using this product, inordinate sun and ultraviolet radiation should be avoided. it has veritably low transdermal immersion, so it's doubtful to interact with systemic specifics. There's no substantiation that the efficacity of oral specifics similar as birth control capsules and antibiotics will be affected by the use of Differin on the skin. Differin may have a mild original vexation effect, and when used with shelling agents, astringents or annoyances, it may beget fresh vexation. thus, using otheranti-acne medicines for skin use similar as erythromycin( attention ≤ 4), clindamycin phosphate( 1) result or benzoyl peroxide waterless gel( attention ≤ 10) in the morning and using Differin gel at night can avoid the collective declination of medicines or the accumulation of vexation.

Adverse reactions

The most common adverse responses in the first 2- 4 weeks of treatment are erythema, blankness, scaling, itching, burning or surcharging, which are substantially mild or moderate in degree. Less common adverse responses are sunburn, skin vexation, burning and surcharging of skin discomfort. Rare adverse responses include acne greenishness, dermatitis and contact dermatitis, eye edema, conjunctivitis, erythema, itching, skin abrasion, rash andeczema.However, the number of specifics should be reduced or discontinued, If the adverse response is serious.

Comparison of the safety of adapalene with other topical retinoids

Traditional topical retinoids( RA) are indeed veritably effective in treating common acne, but their side goods similar as vexation limit their use. RA is unstable due to a series of fragile divalent bond chains in its molecular structure and causes original vexation due to poor receptor selectivity. trials have shown that RA can be degraded by numerous factors within 24 hours of exposure to sun,60.0 to80.0 of the birth RA attention is degraded; if oxidants similar as benzoyl peroxide are used at the same time as RA,80.0 of RA is degraded within 4 hours, and all vanish within 24 hours. In order to find a more stable patch that has the effect of RA and reduces its side goods, people have developed a naphthoic acid outgrowth, adapalene. The reasons why it is less prickly are ① Molecular stability the unstable divalent bond chain of RA is replaced by the sweet ring of naphthoic acid, which makes the patch remain stable under the action of light and oxidants, and won't degrade for 72 hours. ② largely picky receptor list After RA enters the cell, it first binds to the cytoplasmic retinoic acid binding protein( CRABP), and has no selectivity in binding to the nuclear receptors RARα, β, and γ. it doesn't bind to CRABP, but widely binds to the specific amino acids in the receptor list spots of the nuclear receptors RAR- β and RAR- γ, also binds to RXR, and further binds to specific DNA spots, regulating the recap medium, affecting protein conflation, regulating cell proliferation and isolation, so it has high particularity and many side goods. ③ Low cytotoxicity Studies have set up that different retinoic acids have different degrees of cytotoxic goods on keratinocytes. Adapalene motes are neutral, and compared with the long- chain organic acids of retinoic acid, it has lower cytotoxic goods on keratinocytes. ④ Adapalene has a clearanti-inflammatory effect, while other retinoic acids have unclear goods.

In short, as a third- generation retinoic acid medicine, it has a strongeranti-inflammatory effect than all- trans retinoic acid and other retinoic acid medicines, in addition to regulating epidermal cell isolation, inhibiting the proliferation and keratinization of hair follicle keratinocytes, inhibiting the proliferation of sebaceous gland cells, and dissolving keratin entrapments and acne. Due to its unique stability, its efficacity and tolerability are significantly bettered compared with other retinoic acid medicines.

Preparation

1) Under nitrogen atmosphere, add 356g(1.0 spook) of 2- methoxycarbonyl-6-naphthol p- toluenesulfonate, 332g(0.65 spook) of di( 4- methoxy-3-adamantylphenyl) boric acid, 533g( 2 spook) of potassium phosphate trihydrate,6.5 g(0.01 spook) of bistriphenylphosphine nickel chloride and2.2 g(0.01 spook) of N- methyl- N'- butylimidazolium platitude and1.0 L of toluene detergent into a reactor equipped with a influx device, stir and reply at 120 °C until completion, and cool the response result to room temperature.

2) Wash the response result attained in step( 1) with impregnated Neptune, separate the organic phase, dry it, and distill it under normal pressure to recover the detergent. Recrystallize the attained solid with toluene, cool it, and filter the rained solid to gain 6-( 3-( 1- adamantyl)-4-methoxyphenyl)-2-naphthoic acid methyl ester.

3) Dissolve 160 g( 4 spook) of sodium hydroxide in0.5 L of methanol, add to the 6-( 3-( 1- adamantyl)-4-methoxyphenyl)-2-naphthoic acid methyl ester attained in step( 2), and heat under influx until the 6-( 3-( 1- adamantyl)-4-methoxyphenyl)-2-naphthoic acid methyl ester reacts fully.

4) Distill off the organic detergent under normal pressure, acclimate the pH to 1, and sludge to gain 367 g of adapalene.

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Yihui takes pride in being a trusted Adapalene API manufacturer and supplier. To acquire this groundbreaking product or discuss your specific requirements, contact us immediately at sales@yihuipharm.com. Rest assured, with Yihui, you're accessing a product of unparalleled quality, backed by certifications that underscore our commitment to excellence in the global market.