We supply Indometacin

We're a trusted supplier of Indometacin API, furnishing high quality products to our guests. it belongs to the order of nonsteroidalanti-inflammatory medicines( NSAIDs) and is extensively used in the medical assiduity for colorful purposes. Our product is manufactured under strict quality control norms, icing its chastity, energy and stability. We've a largely educated platoon of professionals who are devoted to furnishing excellent client service and support. We supply our Indometacin to pharmaceutical companies, exploration institutions and other guests around the world. communicate us moment to learn further about our product and services.

What's Indometacin ?

Indometacin powder, also known as 2- methyl- 1-( 4- chlorobenzoyl)-5-methoxy-1H-indole-3-acetic acid, belongs to the BCS class II of drugs. It has high permeability, low solubility, poor dissolution, and low bioavailability in vivo. Indomethacin is a white or slightly pusillanimous crystalline cream. Indomethacin is a nonsteroidalanti- seditious drug( NSAID) withanti- seditious, antipyretic, and analgesic goods. It exertsanti- seditious goods by inhibiting cyclooxygenase and reducing prostaglandin emulsion, while its antipyretic effect is related to inhibiting prostaglandin emulsion in the hypothalamus.

Basic Information

Product Name: Indometacin

CAS: 53-86-1

MF:C19H16ClNO4

MW:357.79

EINECS:200-186-5

MDL No.:MFCD00057095

Structural formula:

Origin: China

Delivery Time: in stock

Technical Specification

Package: 1kg or 25kg according to your demands

Storage: Preserve in tight,light-resistant containers in cool place

Shelf Life: 2 years

Function

Indometacin API ( also known as indomethacin) functions primarily as anon-steroidalanti-inflammatory medicine( NSAID) with several crucial conduct

Anti-inflammatory:  Indometacin reduces inflammation by inhibiting the product of prostaglandins, which are composites that promote inflammation in the body.

Analgesic: It provides pain relief by blocking the pathways involved in pain signaling, making it effective for colorful types of pain, including acute and habitual pain.

Antipyretic: Indometacin can lower fever by acting on the hypothalamus to reduce the body’s set point temperature.

Inhibition of Platelet Aggregation: While not its primary use, indometacin can inhibit platelet aggregation, which may be salutary in certain medical situations.

Uricosuric Action: Indometacin can help lower uric acid situations in the blood, making it useful in treating gout attacks.

These functions make Indometacin a protean API for managing pain, inflammation, and associated conditions. still, it's essential to use it under medical supervision due to implicit side goods, similar as gastrointestinal issues, cardiovascular pitfalls, and order goods.

Application

Indometacin powder is anon-steroidalanti-inflammatory medicine( NSAID) generally used for its analgesic andanti-inflammatory parcels. Then are some crucial applications of Indometacin as an active pharmaceutical component( API)

Pain Relief: It's effective in managing mild to moderate pain, including headaches, dental pain, and postoperative pain.

seditious Conditions: Indometacin is used to treat colorful seditious conditions similar as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.

Gout Attacks: It can help palliate pain and inflammation during acute gout attacks.

Menstrual Pain: Indometacin is frequently specified for dysmenorrhea( painful menstrual ages).

Postoperative Inflammation: It may be used to reduce inflammation and pain following surgical procedures.

Patent Ductus Arteriosus( PDA): In neonatology, Indometacin is occasionally used to close a patent ductus arteriosus in unseasonable babies.

Other Conditions: It may also be used in certain cases of bursitis, tendinitis, and other musculoskeletal diseases.

As with any drug, it's important to use Indometacin under the guidance of a healthcare professional due to implicit side goods and contraindications.

Adverse reactions

The prevalence of adverse responses to indomethacin is relatively high, and the common adverse responses are as follows

① Nausea, puking, abdominal pain, diarrhea, poor appetite, and in severe cases, ulcers may do and beget bleeding and perforation. Taking it incontinently after refections can reduce the prevalence rate.

② Common symptoms include headache, dizziness, fatigue, occasional storms, internal confusion, fainting, etc. Attention should be paid to stopping drug in a timely manner.

③ Skin itching, erythema, urticaria, as well as rare asthma attacks, respiratory torture, and indeed respiratory and circulatory repression.

④ Inhibition of the hematopoietic system similar as granulocytopenia, aplastic anemia, thrombocytopenia, etc. Although rare, the consequences are relatively serious. There are also some responses analogous to aspirin, and the preventives are the same.

Synthesis and Structure Activity Relationship of Indomethacin

The chemical structure of indomethacin is n't complex, and the synthetic route is also fairly mature. generally, starting from the affordable and readily available p- anisidine( p- methoxyaniline), it's diazotized and reduced to azo composites by sodium sulfite, followed by farther reduction to hydrazine; After picky acylation, sodium sulfonate is removed under alkaline conditions, and eventually indomethacin can be attained through the classical Fischer indole conflation system.

Chemical synthesis route of indomethacin

Structure performance studies have shown that the acetyl group at the C3 position is an essential functional group foranti-inflammatory exertion, and its acidity is directly commensurable to theanti-inflammatory activity.However, theanti-inflammatory exertion disappears; The exertion of C2 methyl negotiation is stronger than that of aryl negotiation, substantially due to the stereochemistry of the methyl group, If the carboxyl group is replaced with another functional group. The performing emulsion is more active than the unsubstituted emulsion and the 5- chloro substituted emulsion; N- acylation has strongeranti-inflammatory exertion than N- alkylation, with N- arylylation showing better exertion.

Packing & Shipping

Packing：

1kg/foil bag;5kg/carton;25kg/fiber drum; or packing as your request.

Customization:

l Customized logo

l Customized packaging

l Graphic customization

Shipping：

By Courier; By Air or By Sea, according to your demands

Payment Term

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Yihui Pharmaceuticals, as a professional Indometacin API manufacturer and supplier, is committed to delivering exceptional quality. Our adherence to international standards and prestigious certifications, including ISO, Kosher, Halal, and GMP, underscores our dedication to product excellence. For inquiries or to purchase indometacin powder, please contact us immediately at sales@yihuipharm.com. Choose Yihui Pharmaceuticals for unparalleled quality and reliability in every batch of Indometacin.