We supply Atomoxetine hydrochloride API

We are pleased to offer Atomoxetine hydrochloride powder, a selective norepinephrine reuptake inhibitor used in the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Our product complies with global quality standards and is manufactured using advanced technology and rigorous quality control measures. Atomoxetine hcl powder is a potent and effective medication that enhances cognitive functions, improves attention, and reduces impulsivity and hyperactivity in both children and adults. We aim to provide our clients with the best quality products and efficient services, ensuring complete customer satisfaction. Contact us today for more information on our Atomoxetine hydrochloride API.

What's Atomoxetine hydrochloride ?

Atomoxetine hcl is a white or light white solid, soluble in water (27.8 mg/ml). It is the hydrochloride form of the nervous system medication Tomoxetine, which belongs to the adrenal neurotransmitter reuptake inhibitor and is used to treat attention deficit and hyperactivity disorder. Atomoxetine hydrochloride is a selective norepinephrine reuptake inhibitor (SNRI) with a structure similar to fluoxetine. This drug is the first excitatory drug approved by Chemicalbook for the treatment of Attention Deficit Disorder with Hyperactivity Disorder (ADHD), and it has not been found in clinical trials to cause typical reactions to other excitatory drugs or drugs that can cause pleasure. Randomized, placebo-controlled trials conducted in children and adults have confirmed that this product can effectively treat ADHD.

it is the first non excitatory drug used to treat attention deficit hyperactivity disorder (ADHD), and has been marketed and applied in multiple countries including the United States, Australia, Canada, the United Kingdom, and China. it is a highly selective norepinephrine reuptake inhibitor (SNRI) with a molecular formula of C17H21NO · HCl and a chemical name of N-methyl-3-phenyl-3- (O-toloxy) - propylamine hydrochloride. It is highly selective in binding to norepinephrine reuptake transporters on the presynaptic membrane, inhibiting NE reuptake and has extremely low affinity with other neurotransmitters. Its function is to increase the concentration of NE in the synaptic gap, increase the normal phase transmission of NE, and at the same time increase the dopamine (DA) level in the prefrontal cortex. It does not increase DA activity in the nucleus accumbens area and does not lead to abuse or addiction. At the same time, it does not increase DA activity in the striatum area and does not induce tic symptoms or increase motor disorders. Meanwhile, it can indirectly increase DA activity in the prefrontal cortex and potentially improve cognitive function in patients.

Basic Information

Product Name: Atomoxitine HCL

CAS: 82248-59-7

MF:C17H22ClNO

MW:291.82

EINECS:629-925-3

MDL No.:MFCD06410992

Structural formula:

Origin: China

Application: Anti-anxiety/Anti-ADHD API

Delivery Time: in stock

Technical Specification

Package: 1kg; 25kg

Storage: 2-8℃.Store in tight, light- resistant holders, avoid exposure to direct sun, humidity and inordinate heat.

Shelf Life 24 months

Pharmacological action

The exact mechanism of using tocoxetine hydrochloride to treat children with ADHD is not yet clear. Currently, it is believed that the therapeutic effect of this product is related to other selective inhibition of presynaptic amine pump reuptake effects of norepinephrine, which can enhance the flipping effect of norepinephrine, thereby improving the symptoms of children with ADHD, indirectly promoting cognitive completion and attention concentration.

Indications

it is suitable for the treatment of ADHD in children and adolescents.

Synthetic method

Starting from 3-methylamino-1-phenylpropanol, it undergoes etherification reaction with 2-fluorotoluene, and is separated by L - (+) - mandelic acid. Finally, dried hydrogen chloride is used to form a salt, which undergoes a three-step reaction to prepare toroxetine hydrochloride. This synthesis route is simple, with high relative yield, and is suitable for industrial production of the preparation process to synthesize the target compound Atomoxetine hcl powder.

Side effect

Atomoxetine hydrochloride powder  has fewer side effects and mostly occurs in the early stages of treatment, mainly manifested as decreased appetite, insomnia, and fatigue. Possible weight loss will gradually return to normal as treatment progresses. Some patients may experience mild elevation of blood pressure and increased heart rate, but no cardiovascular side effects were found in 169 ADHD patients who were followed up one year after taking it.

Matters needing attention

1. Patients with hypertension, heart disease, hypotension or tendency to hypotension, renal insufficiency, jaundice, liver disease, urinary retention or abnormal bladder function should use with caution.

2. There is still a lack of clinical research data on medication for children under 6 years old, and some children may experience weight loss in the early stages of treatment.

3. There is still a lack of clinical research data on medication for the elderly.

4. Animal experiments have shown that high doses of this product can have teratogenic effects on fetuses. Pregnant women should use it with caution. The FDA has classified the pregnancy safety of this drug as Grade C.

5. Breastfeeding women should use with caution.

6. Patients who are currently taking or have taken monoamine oxidase inhibitors such as phenethylhydrazine and phenylcyclopropylamine within 14 days should not use them.

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In summary, as a professional Atomoxetine hydrochloride powder manufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make it stand out in the market competition and win more customer trust and support. if you need Atomoxetine hcl powder, pls feel free to contact us any time. we will reply you asap.

our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937