We supply Decoquinate powder

We offer Decoquinate powder, a veterinary medicine generally used as a coccidiostat in flesh product. Its primary function is to help and treat coccidiosis, a parasitic complaint that can beget significant profitable losses in flesh flocks. it has also been shown to have a positive impact on growth performance and feed effectiveness in cravens. Our product is of high quality and chastity, icing its effectiveness and safety. communicate us to learn further about our product and how it can profit your flesh operation.

What's Decoquinate?

Decoquinate is a light unheroic crystalline greasepaint. Melting point 86- 87 ℃. Slightly answerable in chloroform and ether, nearly undoable in water. Odorless.

it is a new type of quinolone grounded largely effective beast and flesh anti coccidiosis medicine, generally known as dicoquinone ester, ethyldecanoquine ester, diquinone, dicoquinone ester, benzyloxyquine methyl ester. The original medicine is a white or slightly unheroic crystalline greasepaint, which is extremely answerable in chloroform or ether, undoable in water or ethanol, and has unique anti coccidiosis exertion. Its anti coccidiosis effect is stronger than that of madumifloxacin ammonium, nicarbazine ethoxybenzyl ester, and methylsalinomycin. Studies have shown that it can effectively crush the resistance of coccidiosis. In clinical practice, Used for the forestallment and control of the most dangerous Eimeria tenella,E. maxes,E. acerVulina,E. necatrix,E. brunetti, andE. mixi to flesh Flesh coccidiosis caused by six types of coccidia. It can also help and control neosporidiosis in beast similar as cattle and lamb, as well as cryptosporidiosis in ruminants; It can also increase the weight gain rate and milk product of youthful scapegoats. it plays a part in the asexual reduplication stage of coccidia, and after entering the spore cells, it inhibits their development by snooping with DNA conflation. It starts to play a part in the early stages of the life cycle of coccidia, effectively avoiding intestinal damage caused by coccidia. Adding to feed won't affect the digestion and immersion of nutrients by the power of the feed. This product has no comity restrictions; Can not be used in feed containing adulatory soil. Quinoline grounded anti coccidiosis medicines are prone to develop resistance, and it's recommended to use them only during the peak period of coccidiosis outbreaks, with a outside of 4 weeks of nonstop use. Since the 1970s, decoxyquine has been extensively used in numerous countries for the forestallment and control of avian coccidiosis, but it has not been used in China. In 2006, the American company Yalai was first introduced for trade in the Chinese request, which attracted high attention and wide attention from people. The reasons are as follows it was first used in China, without medicine resistance, and is the most ideal gyration medicine, killing coccidia, promoting growth, perfecting coloring, and has excellent anti coccidian goods and growth promoting performance; It begins to serve in the early stages of the life cycle of coccidia and has the longest duration of action; The diapason of resistance to coccidia is wide, and it has good goods on the six most dangerous types of avian coccidia; Good stability, can maintain stable quality for 4 times under suitable temperature and moisture conditions.

Basic Information

Product Name: Decoquinate

CAS:18507-89-6

MF:C24H35NO5

MW:417.54

EINECS:242-389-1

MDL No.:MFCD00673686

Structural formula:

Purity: 99%+

Origin: China

Application: Anti coccidiosis

Delivery Time: in stock

Technical Specification

Package: 1kg; 25kg

Storage conditions: keep tightly closed, store in a cool dry place.

What is the application？

1. Decoquinate powder is Quinoline based coccidial drugs. As a feed additive to prevent coccidiosis in broiler chickens, 27.2g of this product is added to 1 ton of feed. This product has low toxicity, good tolerance, and a wide safety range. Metabolism is rapid, and after 3 days of discontinuation, the residual drug concentration in each tissue is less than 1ppm.

2. Decoquinate is Antigen insecticides, used for chicken coccidiosis.

Toxicity

Low toxicity and good tolerance; Using 80 times the recommended amount is still safe. Metabolism is fast, and after 3 days of discontinuation, the residual drug concentration in each tissue is less than 1*10-6. Poultry: Add 800ppm (26 times the normal dosage) to the feed and feed continuously for 127 days without any poisoning; Pig: Fed continuously at 800ppm for 10 days without any poisoning.

Pharmacokinetics

The absorption is fast, and the effective concentration against coccidia can be reached within 1 hour. After 3 days, the concentration reaches its peak level. After 5 and 7 days of administration of the final labeled decoxyquine ester to cattle and sheep respectively, a single dose of 14C labeled this product was administered intravenously to cattle and sheep. After 1.5 hours, the radiation in the plasma reached its peak. There is partial metabolism in the rat body, producing three metabolites that cannot be determined in their structure. In ruminant animals, only two metabolites have been identified and their proportion is lower than that of rats. The main excretory pathway of ruminants is feces, followed by urine. In sheep, 36% of the total dose is excreted in urine, of which 35% is excreted within 24 hours. Within 3 days, decanoquine and its metabolites are completely excreted in urine.

Combination therapy

In order to improve the anti coccidiosis effect and reduce the occurrence of drug resistance, combination therapy can be adopted. In the early stage of coccidiosis (asexual reproduction period of coccidia), the use of a combination of decoxyquinoline ester+diclazulide or trastuzulide, tetracycline+madumicin ammonium, tetracycline+chlorpyrifos, etc. can exert drug synergy, enhance the killing effect, and reduce the dosage of each drug by half. During the entire period of coccidiosis, a combination medication regimen of tetracycline and sulfamethoxazole sodium, or tetracycline and sulfamethoxazole sodium can be used to suppress and kill both asexual and sexual stages of coccidiosis.

Production methods

3,4-Dihydroxynitrobenzene reacts with bromodecane in DMF medium to produce 3-hydroxy-4-decanoxynitrobenzene. Then, through ethoxylation and reduction, 3-ethoxy-4-decanoxyaniline is obtained. Then, 3-ethoxy-4-decanoxyaniline is condensed with ethoxymethylenemalonate diethyl ester to obtain 3-ethoxy-4-decanoxyaniline methylenemalonate diethyl ester. Finally, the final product is obtained by heating and condensation with thermal conductivity A.

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Xi'an Yihui company as a professional Decoquinate powdermanufacturer has strong technical strength and advanced production equipment and is committed to providing customers with high-quality, efficient and reliable drug raw materials. if you need Decoquinate, pls feel free to contact us any time. we will reply you ASAP.

Our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937