We supply Alagebrium Chloride

We're proud to offer Alagebrium Chloride, a potent emulsion with implicit remedial operations. Known for its capability to alleviate oxidative stress and reduce inflammation, it is generally used in the field of cardiology to address issues related to hypertension and other cardiovascular conditions. As a trusted supplier, we take great care to insure the chastity and efficacity of our Alagebrium Chloride, with a fidelity to quality that extends throughout our entire product process. So if you are looking for a dependable source of it for your exploration or clinical requirements, look no further than us.

What is Alagebrium Chloride?

Alagebrium Chloride also know as ALT-711. it is a chemical emulsion that has garnered significant attention in recent times due to its implicit remedial parcels. It's also known by its trade name Thiazolium Chloride. it has been shown to plyanti-aging goods by perfecting the function of growing cells and apkins. It works by inhibiting the conformation of advanced glycation end- products( periods), which are a hallmark of aging. periods are formed when proteins and other motes in the body are exposed to high situations of sugar, either through salutary input or due to metabolic dysfunction. These motes can accumulate in apkins and organs, leading to inflammation, oxidative stress, and damage to cellular structures. it helps to help the conformation of periods by blocking the exertion of an enzyme called transketolase. This enzyme is involved in the product of the precursor motes that go on to form periods. In addition to itsanti-aging goods, it has also shown pledge as a treatment for a range of other conditions. These include diabetes, heart complaint, and habitual order complaint, all of which are associated with increased AGE conformation.

Clinical studies have demonstrated that it can ameliorate vascular function, reduce arterial stiffness, and increase insulin perceptivity in cases with diabetes. It has also been shown to ameliorate heart function and reduce the threat of cardiovascular events in cases with heart failure.

it is still witnessing clinical trials, but the results so far suggest that it has significant eventuality as a remedial agent for a range of conditions. Its capability to help the conformation of periods makes it a particularly seductive seeker for the treatment of age- related conditions similar as Alzheimer's and Parkinson's.

Overall, it represents a promising new avenue for the development of rectifiers to ameliorate health and extend lifetime.

Basic Information

Product Name: Alagebrium chloride

CAS: 341028-37-3

MF:C13H14ClNOS

MW:267.77

EINECS:636-473-0

MDL No.:MFCD09027398

Structural formula:

Origin: China

Delivery Time: in stock

Technical Specification

Package: 10g;100g;1kg; or according to your demands

Storage conditions: protected from light and moisture, sealed and dry

Transportation conditions: 2-8 ℃ transportation

Shelf Life:Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Biological activity

Alagebrium chloride is a potent medicine that possesses unique natural exertion. This emulsion is a small patch that targets age- related changes and reverses them, making it an seductive remedial agent for age- related conditions. It not only improves cardiovascular health but also ameliorates glucose dogmatism and prevents insulin resistance, making it a promising implicit medicine for diabetes treatment.

it functions as a potent reactive oxygen species scavenger, a process that results in the preservation of endothelial cell function and vascular homeostasis. Its effect on vascular function includes perfecting roadway pliantness and reducing arterial stiffness, leading to a decline in blood pressure. also, it modulates colorful pathways involved in cell death, inflammation, and oxidative stress, which are the primary contributors to the progression of age- related conditions.

The unique medium of action has been considerably studied in preclinical models, which has led to its blessing for clinical trials. It has been shown to have an excellent safety profile and minimum side goods, making it a promising seeker for clinical use. The clinical trials conducted therefore far have demonstrated its efficacity in perfecting arterial stiffness, enhancing endothelial cell function, and reducing blood pressure.

In conclusion, it holds great pledge as a remedial agent for age- related conditions. Its unique natural exertion in combating aging and other age- related conditions, coupled with its exceptional safety profile, makes it an instigative emulsion that could inspire unborn medicine development.

In vitro exploration

ALT-711 is an advanced glycationend product( AGE)inhibitor.Endothelialcell( EC) prolife rationisincreased for all group sreceiving Alagebrium( ALT- 711), particularlywhenseededonmatrixfromtheAAoofobese( ZO) anddiabetic( ZD) rats.

In vivo exploration

KOmiceisassociatedwithafurtherreductChemicalbookioninglomerularcollagenIVlevels,approachinglevelsobservedincontrolmice.Bodyweight, heartrate( HR), andmeanbloodpressure( BP) aresimilarinZuckerlean( ZL), fat( ZO), anddiabetic( ZD) groupsintheabsenceorpresenceof Alagebrium( ALT- 711). Alagebriumincreasesbloodflow( BF)inZOratsbutreducesdistalvascularresistanceinZDrats.Adecreaseinneointimalhyperplasia( NH)intrastrutthicknessasafunctionoflocalradiusisfoundinallgroupswith Alagebrium treatment. AsignificantincreaseinTGF- βexpressionisalsofoundintheAAo of ZLratstreated with Alagebrium.

Beast trials

Rat aortic vascular smooth muscle cells( RASMCs) were treated with 1- 100 μM of alagebrium added 24 hours before the addition of periods.? This in vivo study was done using 8- week-old manly rats that were fitted intraperitoneally with 80 mg/ kg STZ.? Sixteen weeks latterly, the diabetic rats were treated with 10 mg/ kg alagebrium for 4 weeks, after which carotid roadway balloon injury was convinced.? After 4 weeks, the creatures were offered for histological analysis

Solution Preparation Table

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Our Advantage

Rich experience: we have 13 Years of professional experience;

Customers all over the world: sell to more than 100 countries;

Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.

Price advance: low MOQ with competitive price;

Quality certification: ISO; Halal; Kosher certified

After-sales service: Professional team 7*24 hours customer service.

Contact Us:

Yihui takes pride in being a trusted ALT-711 manufacturer and supplier. To acquire this groundbreaking product or discuss your specific requirements, contact us immediately at sales@yihuipharm.com. Rest assured, with Yihui, you're accessing a product of unparalleled quality, backed by certifications that underscore our commitment to excellence in the global market.